Abstract: A method of generating an isolated population of cells comprising anti-third party cells having a central memory T-lymphocyte (Tcm) phenotype, the cells being tolerance-inducing cells and/or endowed with anti-disease activity, and capable of homing to the lymph nodes following transplantation is disclosed. The method comprising: (a) contacting peripheral blood mononuclear cells (PBMC) with a third party antigen or antigens in the presence of IL-21 so as to allow enrichment of antigen reactive cells; and (b) culturing the cells resulting from step (a) in the presence of IL-21, IL-15 and IL-7 in an antigen free environment so as to allow proliferation of cells comprising the central memory T-lymphocyte (Tcm) phenotype.

Abstract: Architecture that addresses security concerns while still providing transparent user experience with ability to perform tasks. When a user machine is considered incompliant or compromised due to, for example, a suspected infection, the user machine can be blocked from further access to a network or other computing hosts until the incompliance is resolved. A notification is presented that indicates the nature of the problem, and a way to access an automatically configured isolated environment via which to continue working. The user can be automatically routed to use the alternative isolated environment for temporary access to network resources. Once the user finishes activities in the isolated environment, the system hosting the isolated environment is reverted back to a known good state.

Abstract: Architecture that addresses security concerns while still providing transparent user experience with ability to perform tasks. When a user machine is considered incompliant or compromised due to, for example, a suspected infection, the user machine can be blocked from further access to a network or other computing hosts until the incompliance is resolved. A notification is presented that indicates the nature of the problem, and a way to access an automatically configured isolated environment via which to continue working. The user can be automatically routed to use the alternative isolated environment for temporary access to network resources. Once the user finishes activities in the isolated environment, the system hosting the isolated environment is reverted back to a known good state.