Abstract: Described herein are method of generating and uses of polypeptides with dual binding specificity, wherein the polypeptides contain a first binding-site for a first antigen and a second binding-site for a second antigen. The second binding-site comprises amino acid variants of native amino acid sequences of polypeptides that bind to the first antigen, wherein the variants do not abrogate binding to said first antigen. In one embodiment, polypeptides with dual binding specificity to PD1 and OX40 are disclosed herein. In another embodiment, polypeptides with dual binding specificity to PD1 and GITR are disclosed herein.

Abstract: A flexible advance system allows users to request and receive advances instantly. The flexible advance system facilitates intra-system transfers between a third-party entity and employee accounts at a third-party system by generating and providing funding instructions to the third-party entity. Funding instructions include a funding amount that the flexible advance system predicts using one or more machine-learned models that account for seasonality and time delays. In executing the instructions from the flexible advance system, the third-party entity transfers funds to its entity account with the third-party system based on the funding amount. Once the flexible advance system receives an indication that the third-party entity has executed the instructions, the flexible advance system authorizes users of the flexible advance system to request short-term advances.

Abstract: A flexible advance system allows users to request and receive advances instantly. The flexible advance system facilitates intra-system transfers between a third-party entity and employee accounts at a third-party system by generating and providing funding instructions to the third-party entity. Funding instructions include a funding amount that the flexible advance system predicts using one or more machine-learned models that account for seasonality and time delays. In executing the instructions from the flexible advance system, the third-party entity transfers funds to its entity account with the third-party system based on the funding amount. Once the flexible advance system receives an indication that the third-party entity has executed the instructions, the flexible advance system authorizes users of the flexible advance system to request short-term advances.

Abstract: A flexible advance system allows users to request and receive advances instantly. The flexible advance system facilitates intra-system transfers between a third-party entity and employee accounts at a third-party system by generating and providing funding instructions to the third-party entity. Funding instructions include a funding amount that the flexible advance system predicts using one or more machine-learned models that account for seasonality and time delays. In executing the instructions from the flexible advance system, the third-party entity transfers funds to its entity account with the third-party system based on the funding amount. Once the flexible advance system receives an indication that the third-party entity has executed the instructions, the flexible advance system authorizes users of the flexible advance system to request short-term advances.

Abstract: The invention comprises a two-part support member for curtain walls capable of withstanding the extreme loads required for extra-large walls with minimal deformation comprising two independently extrudable components, each of which may be produced on standard extruders and attachment means that holds the extrudable components together. The sections fit together in such a way that inevitable deformations that occur during production are taken into account and corrected for. Due to the hitherto unattainable stiffness values that this combination of components may reach, extra-large curtain walls mounting and supporting is achieved that was otherwise unattainable. The cross sectional area of the sections is relatively small allowing for lightweight members to be extruded that use a minimum of material.

Abstract: The invention comprises a two-part support member for curtain walls capable of withstanding the extreme loads required for extra-large walls with minimal deformation comprising two independently extrudable components, each of which may be produced on standard extruders and attachment means that holds the extrudable components together. The sections fit together in such a way that inevitable deformations that occur during production are taken into account and corrected for. Due to the hitherto unattainable stiffness values that this combination of components may reach, extra-large curtain walls mounting and supporting is achieved that was otherwise unattainable. The cross sectional area of the sections is relatively small allowing for lightweight members to be extruded that use a minimum of material.