Patents by Inventor Yajie Niu

Yajie Niu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250075227
    Abstract: Synthetic endornaviral satellite RNA molecules and satellite particles containing the same are disclosed. The synthetic endornaviral satellite RNA molecules can include coding and/or non-coding cargo sequences, and are heritable through generations of plants. Also disclosed are methods of using the endornaviral satellite RNA molecules and satellite particles containing the same to change plant phenotypes, improve plant stress resistance, and improve plant pest and pathogen resistance.
    Type: Application
    Filed: November 14, 2024
    Publication date: March 6, 2025
    Inventors: Arjun Devang Khakhar, Barry Andrew Martin, Yajie Niu, Daniel Alexander Sprague, Elizabeth Jane Antonelli Dennis, Mehmet Ali Halac, Yumeng Hao, Jayashree Kumar, Michka Gabrielle Sharpe, Aditya Sushil Kumar Singh, James Michael Kremer, Fu Chyun Chu, Kevin Klicki, Chien-Yuan LIN, Shankar Raj Pant, Derek Thomas Rothenheber
  • Patent number: 12209246
    Abstract: Disclosed herein are compositions and methods for effecting alterations at a defined location in the genome of a non-epidermal plant cell. Further disclosed are methods for providing plants having a modified phenotype or a modified genome.
    Type: Grant
    Filed: February 7, 2022
    Date of Patent: January 28, 2025
    Assignee: FLAGSHIP PIONEERING INNOVATIONS V, INC.
    Inventors: Randall William Shultz, John P. Casey, Jr., Barry Andrew Martin, Yajie Niu, Kristine Yu, Brian Prescott Fiske
  • Publication number: 20240417749
    Abstract: Synthetic endornaviral satellite RNA molecules and satellite particles containing the same are disclosed. The synthetic endornaviral satellite RNA molecules can include coding and/or non-coding cargo sequences, and are heritable through generations of plants. Also disclosed are methods of using the endornaviral satellite RNA molecules and satellite particles containing the same to change plant phenotypes, improve plant stress resistance, and improve plant pest and pathogen resistance.
    Type: Application
    Filed: October 31, 2022
    Publication date: December 19, 2024
    Inventors: Arjun Devang Khakhar, Barry Andrew Martin, Yajie Niu, Daniel Alexander Sprague, Fu Chyun Chu, Elizabeth Jane Antonelli Dennis, Mehmet Ali Halac, Yumeng Hao, Kevin Klicki, James Michael Kremer, Jayashree Kumar, Chien-Yuan LIN, Shankar Raj Pant, Derek Thomas Rothenheber, Michka Gabrielle Sharpe, Aditya Sushil Kumar Singh
  • Patent number: 12163142
    Abstract: Disclosed herein are methods, and related bioreactors, for manufacturing plant messenger packs (PMPs), which can be formulated for use in a variety of agricultural and therapeutic methods.
    Type: Grant
    Filed: August 24, 2019
    Date of Patent: December 10, 2024
    Assignee: Flagship Pioneering Innovations VI, LLC
    Inventors: Maria Helena Christine Van Rooijen, Hok Hei Tam, Barry Andrew Martin, Daniel Garcia Cabanillas, Simon Schwizer, Nataliya Vladimirovna Nukolova, Yajie Niu
  • Publication number: 20240263206
    Abstract: The present disclosure relates, generally, to compositions and methods for producing, purifying, and using circular RNA.
    Type: Application
    Filed: March 25, 2022
    Publication date: August 8, 2024
    Inventors: Barry Andrew Martin, Swetha Srinivasa Murali, Yajie Niu, Derek Thomas Rothenheber, Michka Gabrielle Sharpe, Andrew McKinley Shumaker
  • Publication number: 20240254497
    Abstract: Disclosed herein are viroid-derived polynucleotides for the modification of plants and methods of using such polynucleotides in a variety of agricultural and commercial methods. Specifically, the disclosure provides a method of delivering to a plant a composition comprising a recombinant polynucleotide comprising: (i) a single-stranded RNA (ssRNA) viroid sequence and (ii) a heterologous RNA sequence comprising or encoding an effector, wherein the effector has a biological effect on the plant, and wherein the viroid is potato spindle tuber viroid (PSTVd) or eggplant latent viroid (ELVd).
    Type: Application
    Filed: July 20, 2021
    Publication date: August 1, 2024
    Inventors: Yajie Niu, Swetha Srinivasa Murali, Michka Gabrielle Sharpe, Barry Andrew Martin
  • Patent number: 12043838
    Abstract: Systems, methods, and compositions for providing improvements in plant gene-editing efficiency are provided.
    Type: Grant
    Filed: March 6, 2023
    Date of Patent: July 23, 2024
    Assignee: INARI AGRICULTURE TECHNOLOGY, INC.
    Inventors: Hannah Pham, Yajie Niu, Erik William Clement
  • Publication number: 20240181079
    Abstract: The present disclosure relates, generally, to methods for producing, purifying, and using circular RNA from a eukaryotic system.
    Type: Application
    Filed: March 25, 2022
    Publication date: June 6, 2024
    Inventors: Barry Andrew Martin, Swetha Srinivasa Murali, Yajie Niu, Derek Thomas Rothenheber, Michka Gabrielle Sharpe, Andrew McKinley Shumaker
  • Publication number: 20240141370
    Abstract: Disclosed herein are agricultural compositions comprising plant messenger packs (PMPs), methods for using the same, and methods and related bioreactors for manufacturing PMPs.
    Type: Application
    Filed: October 20, 2023
    Publication date: May 2, 2024
    Inventors: Maria Helena Christine VAN ROOIJEN, Hok Hei TAM, Barry Andrew MARTIN, Daniel Garcia CABANILLAS, Simon SCHWIZER, Nataliya Vladimirovna NUKOLOVA, Yajie NIU
  • Patent number: 11926835
    Abstract: The disclosure relates to improvements in methods for efficient editing of two or more endogenous tomato genes by insertion of one or more single stranded DNA donor molecules that are not homologous to the insertion sites in the tomato genome.
    Type: Grant
    Filed: January 29, 2019
    Date of Patent: March 12, 2024
    Assignee: INARI AGRICULTURE TECHNOLOGY, INC.
    Inventors: Tomá{hacek over (s)} {hacek over (C)}ermák, Richard Bailey Flavell, Eva Konecna, Yajie Niu, Michael Lee Nuccio, Jennifer A. Raji, Randall William Shultz, Davide Sosso, Maria Margarita D. Unson, John Patrick Casey, Jr., Michael Andreas Kock
  • Patent number: 11866719
    Abstract: The disclosure relates to precise modifications in wheat plant genomes including the heterologous integration of nucleic acid sequences that include a regulatory element at a predetermined locus. Also provided are wheat cells, wheat plants, wheat seeds, and processed wheat products comprising the modified wheat genomes.
    Type: Grant
    Filed: June 4, 2019
    Date of Patent: January 9, 2024
    Assignee: INARI AGRICULTURE TECHNOLOGY, INC.
    Inventors: Tomá{hacek over (s)} Cermák, Richard Bailey Flavell, Michael Andreas Kock, Eva Konecna, Yajie Niu, Michael Lee Nuccio, Jennifer Raji, Randall William Shultz, Davide Sosso, Maria Margarita D. Unson, John P. Casey, Jr., Jonathan Dallas George Jones
  • Patent number: 11859219
    Abstract: Disclosed herein are compositions and methods for effecting alterations at a defined location in the genome of a plant cell or plant protoplast. Further disclosed are methods using an RNA-guided nuclease to alter a target nucleotide sequence in a cell or protoplast of a plant; embodiments of such methods include treatments with chemical or physical reagents or treatment of the cell or protoplast with a specific thermal regime, such as a heat treatment.
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: January 2, 2024
    Assignee: Flagship Pioneering Innovations V, Inc.
    Inventors: Yajie Niu, Kristine Yu, Frank Anthony Skraly, Randall William Shultz, John P. Casey, Jr., Brian Prescott Fiske
  • Patent number: 11827897
    Abstract: Disclosed herein are agricultural compositions comprising plant messenger packs (PMPs), methods for using the same, and methods and related bioreactors for manufacturing PMPs.
    Type: Grant
    Filed: September 9, 2021
    Date of Patent: November 28, 2023
    Assignee: Flagship Pioneering Innovations VI, LLC
    Inventors: Maria Helena Christine Van Rooijen, Hok Hei Tam, Barry Andrew Martin, Daniel Garcia Cabanillas, Simon Schwizer, Nataliya Vladimirovna Nukolova, Yajie Niu
  • Patent number: 11802288
    Abstract: The disclosure relates to improvements in methods for efficient editing of two or more endogenous soybean genes by insertion of one or more single stranded DNA donor molecules that are not homologous to the insertion sites in the soybean genome.
    Type: Grant
    Filed: January 29, 2019
    Date of Patent: October 31, 2023
    Assignee: INARI AGRICULTURE TECHNOLOGY, INC.
    Inventors: Tomáš Cermák, Richard Bailey Flavell, Eva Konecna, Yajie Niu, Michael Lee Nuccio, Jennifer A. Raji, Randall William Shultz, Davide Sosso, Maria Margarita D. Unson, John P. Casey, Jr., Michael Andreas Kock
  • Publication number: 20230332169
    Abstract: The disclosure relates to gene edited wheat plants, seeds, and compositions, as well as improvements to wheat plant breeding and methods for creating modifications in wheat plant genomes.
    Type: Application
    Filed: June 26, 2023
    Publication date: October 19, 2023
    Inventors: Tomá{hacek over (s)} Cermák, Richard Bailey Flavell, Michael Andreas Kock, Eva Konecna, Yajie Niu, Michael Lee Nuccio, Jennifer A. Raji, Randall William Shultz, Davide Sosso, Maria Margarita D. Unson, John Patrick Casey, JR., Jonathan Dallas George Jones
  • Publication number: 20230279412
    Abstract: The invention relates to novel soybean plants, seeds and compositions, as well as improvements to plant breeding and methods for creating modifications in plant genomes.
    Type: Application
    Filed: April 18, 2023
    Publication date: September 7, 2023
    Inventors: Tomá{hacek over (s)} Cermák, Richard Bailey Flavell, EVA KONECNA, Yajie Niu, Michael Lee Nuccio, Jennifer A. Raji, RANDALL WILLIAM SHULTZ, Davide Sosso, Maria Margarita D. Unson, John Patrick Casey, Jr., Michael Andreas Kock
  • Patent number: 11746354
    Abstract: Compounds and related reagents, systems, methods, and compositions for increasing the frequency of homology directed repair (HDR) of target genomic sites with genome editing molecules are provided.
    Type: Grant
    Filed: July 16, 2020
    Date of Patent: September 5, 2023
    Assignee: INARI AGRICULTURE TECHNOLOGY, INC.
    Inventors: Erik William Clement, Yajie Niu, Hannah Pham
  • Patent number: 11718845
    Abstract: Plant cell cultures as well as related methods, systems, and compositions for increasing the frequency and efficiency of plant genome editing are provided. Various plant cell growth conditions and/or treatments where such increases in gene editing frequencies are obtained are disclosed.
    Type: Grant
    Filed: September 27, 2021
    Date of Patent: August 8, 2023
    Assignee: INARI AGRICULTURE TECHNOLOGY, INC.
    Inventors: Erik William Clement, Yajie Niu, Frank Anthony Skraly
  • Publication number: 20230242927
    Abstract: The invention relates to novel plants, seeds and compositions, as well as improvements to plant breeding and methods for creating modifications in plant genomes.
    Type: Application
    Filed: February 10, 2023
    Publication date: August 3, 2023
    Inventors: Yajie Niu, Randall William Shultz, Maria Margarita D. Unson, Michael Andreas Kock, John Patrick Casey, Jr.
  • Publication number: 20230235349
    Abstract: The invention relates to novel maize plants, seeds and compositions, as well as improvements to maize plant breeding and methods for creating modifications in maize plant genomes.
    Type: Application
    Filed: February 9, 2023
    Publication date: July 27, 2023
    Inventors: Richard Bailey Flavell, Yajie Niu, Michael Lee Nuccio, Randall William Shultz, Davide Sosso, Maria Margarita D. Unson, John Patrick Casey, Jr., Barry Andrew Martin