Abstract: This disclosure provides modified nucleic acids and compositions thereof that are able to mimic the human HULC lncRNA and/or the mouse Pair lncRNA and enhance phenylalanine hydroxylase enzyme (PAH)-substrate binding affinity, PAH-cofactor binding affinity, and/or PAH enzymatic conversion of phenylalanine to tyrosine. Also provided are methods of using the modified nucleic acids and compositions thereof to treat subjects having or suspected of having phenylketonuria and hyperphenylalaninemia.

Abstract: Molecular probe compounds according to the formula P-L-I are described. P is a targeting peptide selected from the group consisting of SEQ ID NO: 1 to SEQ ID NO: 117; I is an imaging agent; and L is an optional non-peptide linker that covalently links the peptide to the imaging agent, wherein the linker comprises a carboxylic acid that forms a carboxamide with an amine of the targeting peptide or a maleimide that forms a thioester bond with a cysteine residue of the targeting peptide. Methods of detecting cancer and monitoring the treatment of cancer using the molecular probes are also described.

Abstract: Disclosed are measurement method and device, information interchange method and device and residence method and device. The measurement method includes configuring measurement configuration information about a UE and sending same, the measurement configuration information including a measurement report trigger condition for a reference cell, so that the UE reports a measurement result when satisfying the measurement report trigger condition. The information interchange method includes interchanging discontinuous data transmission parameter configuration information with a fourth base station, so that a base station side executes scheduling and/or mobility management on a user equipment. The residence method includes sending indication information to a UE, the indication information being used for indicating whether the UE can reside in this cell or not, an object of the UE that can be resident, an object of the UE that cannot be resident, and at least one of the size and type of the cell.

Abstract: A method and a device for establishing an Evolved Packet System (EPS) bearer, where the method includes establishing, by a first base station to which a user equipment (UE) belongs, a first EPS bearer based on a first component carrier (CC) for the UE, wherein the first EPS bearer is an EPS bearer between the first base station and the UE; and instructing, by the first base station, a second base station to establish a second EPS bearer based on a second CC for the UE, wherein the second EPS bearer is an EPS bearer between the second base station and the UE. The present disclosure enables the UE to aggregate carriers of different frequency ranges from the first base station to which the UE belongs and the second base station to which the UE belongs to transmit data, thus improving the throughput of the data transmitted by the UE.

Abstract: Embodiments of the present invention relate to an RRC connection method and a serving node. In the embodiments, an RRC connection is established between an anchor node and UE. Therefore, when an serving node of the UE is switched, a connection between an MME and the anchor node does not change. When the MME needs to send a paging message, the MME does not need to send the paging message to all base stations in a TA area that corresponds to the paging message, thereby effectively reducing signaling load of a core network.

Abstract: Embodiments of the present invention relate to an RRC connection method and a serving node. In the embodiments, an RRC connection is established between an anchor node and a UE. Therefore, when a serving node of the UE is switched, a connection between an MME and the anchor node does not change. When the MME needs to send a paging message, the MME does not need to send the paging message to all base stations in a TA area that corresponds to the paging message, thereby effectively reducing signaling load of a core network.

Abstract: The present disclosure relates to a connection control apparatus and method. The method includes: receiving a link configuration request message sent by a second terminal; sending a bearer configuration request message to a network-side device according to the link configuration request message; receiving a bearer configuration complete message that is sent by the network-side device according to the bearer configuration request message; establishing a mapping relationship between the service bearer and the second terminal; and sending a link configuration complete message to the second terminal after the mapping relationship is established, so that the second terminal performs data transmission with the network-side device over the service bearer by using the first terminal.

Abstract: Disclosed are measurement method and device, information interchange method and device and residence method and device. The measurement method includes configuring measurement configuration information about a UE and sending same, the measurement configuration information including a measurement report trigger condition for a reference cell, so that the UE reports a measurement result when satisfying the measurement report trigger condition. The information interchange method includes interchanging discontinuous data transmission parameter configuration information with a fourth base station, so that a base station side executes scheduling and/or mobility management on a user equipment. The residence method includes sending indication information to a UE, the indication information being used for indicating whether the UE can reside in this cell or not, an object of the UE that can be resident, an object of the UE that cannot be resident, and at least one of the size and type of the cell.

Abstract: A method and a device for establishing an Evolved Packet System (EPS) bearer, where the method includes establishing, by a first base station to which a user equipment (UE) belongs, a first EPS bearer based on a first component carrier (CC) for the UE, wherein the first EPS bearer is an EPS bearer between the first base station and the UE; and instructing, by the first base station, a second base station to establish a second EPS bearer based on a second CC for the UE, wherein the second EPS bearer is an EPS bearer between the second base station and the UE. The present disclosure enables the UE to aggregate carriers of different frequency ranges from the first base station to which the UE belongs and the second base station to which the UE belongs to transmit data, thus improving the throughput of the data transmitted by the UE.

Abstract: Disclosed are measurement method and device, information interchange method and device and residence method and device. The measurement method includes configuring measurement configuration information about a UE and sending same, the measurement configuration information including a measurement report trigger condition for a reference cell, so that the UE reports a measurement result when satisfying the measurement report trigger condition. The information interchange method includes interchanging discontinuous data transmission parameter configuration information with a fourth base station, so that a base station side executes scheduling and/or mobility management on a user equipment. The residence method includes sending indication information to a UE, the indication information being used for indicating whether the UE can reside in this cell or not, an object of the UE that can be resident, an object of the UE that cannot be resident, and at least one of the size and type of the cell.

Abstract: A method and a device for establishing an evolved packet system EPS bearer are disclosed. The method includes establishing, by a first base station to which UE belongs, a first EPS bearer based on a first CC for the UE, wherein the first EPS bearer is an EPS bearer between the first base station and the UE; and instructing, by the first base station, a second base station to establish a second EPS bearer based on a second CC for the UE, wherein the second EPS bearer is an EPS bearer between the second base station and the UE. The present invention enables the UE to aggregate carriers of different frequency ranges from the first base station to which the UE belongs and the second base station to which the UE belongs to transmit data, thus improving the throughput of the data transmitted by the UE.

Abstract: Embodiments of the present invention disclose a method for performing communication by using an unlicensed spectrum, a device, and a system, which relate to the field of communications technologies, so as to improve efficiency of using an unlicensed spectrum by user equipment. The method includes: obtaining, by a base station eNB, a time resource and/or a frequency resource by contending with another eNB or another system using an unlicensed spectrum; generating, by the base station eNB, information about the time resource and/or the frequency resource according to the time resource and/or the frequency resource; and sending, by the base station eNB, the information about the time resource and/or the frequency resource to user equipment UE by using a broadcast or multicast message, so that the user equipment UE communicates with the base station eNB according to the information about the time resource and/or the frequency resource.

Abstract: Embodiments of the present invention provide a method, a device, and a system for determining timing advance grouping, and relate to the field of communications, the method, device and system for determining timing advance grouping. The method includes adding, by a base station (eNodeB), a component carrier (CC) for a user equipment (UE); according to obtained timing advance (TA) group information or a preset rule, determining a TA group that the added CC belongs to, where the TA group is a set of CCs that can share a TA; and sending identification information that identifies the TA group to the UE. Embodiments of the present invention are used to determine TA grouping when the eNodeB adds the CC for the UE.

Abstract: An uplink synchronization processing method, a User Equipment (UE), and a base station are provided. The method includes: receiving a component carrier (CC) uplink synchronization indication message sent by a base station, where the uplink synchronization indication message carries identification information of one or multiple newly configured CCs; sending synchronization signaling to the base station when determining that the uplink synchronization needs to be executed on all or a part of the one or multiple newly configured CCs corresponding to the identification information; and receiving a time advanced (TA) adjusting message that is sent by the base station according to the synchronization signaling, and applying a TA value carried in the TA adjusting message to the CC on which the uplink synchronization needs to be executed.

Abstract: A method and a device for establishing an evolved packet system EPS bearer are disclosed. The method includes establishing, by a first base station to which UE belongs, a first EPS bearer based on a first CC for the UE, wherein the first EPS bearer is an EPS bearer between the first base station and the UE; and instructing, by the first base station, a second base station to establish a second EPS bearer based on a second CC for the UE, wherein the second EPS bearer is an EPS bearer between the second base station and the UE. The present invention enables the UE to aggregate carriers of different frequency ranges from the first base station to which the UE belongs and the second base station to which the UE belongs to transmit data, thus improving the throughput of the data transmitted by the UE.

Abstract: Embodiments of the present invention provide a data transmission method, including: receiving, by second UE, a first message sent by first UE or a base station, where the first message includes relay request information; sending, by the second UE, a second message to the base station according to the first message, where the second message includes information indicating that the second UE requests to act as relay UE for data transmission between the first UE and the base station; and receiving, by the second UE, a third message sent by the base station, where the third message instructs the second UE to act as the relay UE.

Abstract: Embodiments of the present invention provide a method, a device, and a system for determining timing advance grouping, and relate to the field of communications, the method, device and system for determining timing advance grouping. The method includes adding, by a base station (eNodeB), a component carrier (CC) for a user equipment (UE); according to obtained timing advance (TA) group information or a preset rule, determining a TA group that the added CC belongs to, where the TA group is a set of CCs that can share a TA; and sending identification information that identifies the TA group to the UE. Embodiments of the present invention are used to determine TA grouping when the eNodeB adds the CC for the UE.

Abstract: A cosmetic composition is disclosed comprising particle active and cosmetically acceptable carrier comprising hydrophobic material, wherein the hydrophobic material comprises less than 15% liquid oil by weight of the composition. The particle active comprises (i) water-insoluble shell component comprising inorganic material and having a refractive index of from 1.3 to 1.8; and (ii) core component comprising volatile liquid and having a refractive index of at least 1.2.

Abstract: Embodiments of the present invention provide a method, a device, and a system for determining timing advance grouping. In one embodiment, a base station adds a component carrier (CC) for a user equipment (UE). The base station determines a timing advance (TA) group to which the added CC belongs. The TA group is a set of CCs that can share a TA. The base station sends identification information that identifies the TA group to the UE.

Abstract: A cosmetic composition is disclosed comprising particle active; opacifying particles having a refractive index of at least 1.7 and cosmetically acceptable carrier. The particle active comprises (i) water-insoluble shell component comprising inorganic material and having a refractive index of from 1.3 to 1.8; and (ii) core component comprising volatile liquid and having a refractive index of at least 1.2.