Abstract: A lock, a vehicle parking system, and a vehicle parking method are provided. The lock includes a main body, a lock switch, a lock controller, a lock communication circuit, and a battery. The battery is connected to the lock switch, the lock controller, and the lock communication circuit, and configured to supply electrical energy to the lock switch, the lock controller, and the lock communication circuit. The lock communication circuit is connected to the lock controller, and transmits a locking instruction or an unlocking instruction to the lock controller when receiving the locking instruction or the unlocking instruction from a second device located outside the lock. The lock controller is connected to the lock switch connected to the main body, and the lock controller controls, when receiving the locking instruction or the unlocking instruction, the main body to perform a locking operation or an unlocking operation through the lock switch.

Abstract: A light-modulating element, a backlight module, a display device and a method for controlling the same are provided. The light-modulating element includes a first substrate and a second substrate arranged opposite to each other, and a polymer dispersed liquid crystal layer located between the first substrate and the second substrate. The light-modulating element is divided into a plurality of light-modulating zones, and the light-modulating element further includes a first electrode and a second electrode located in each of the plurality of light-modulating zone. A plurality of first electrodes located in different light-modulating zones are independently arranged, and the first electrode and the second electrode are configured to drive a deflection of polymer dispersed liquid crystal molecules in polymer dispersed liquid crystal layer.

Abstract: A lock, a vehicle parking system, and a vehicle parking method are provided. The lock includes a main body, a lock switch, a lock controller, a lock communication circuit, and a battery. The battery is connected to the lock switch, the lock controller, and the lock communication circuit, and configured to supply electrical energy to the lock switch, the lock controller, and the lock communication circuit. The lock communication circuit is connected to the lock controller, and transmits a locking instruction or an unlocking instruction to the lock controller when receiving the locking instruction or the unlocking instruction from a second device located outside the lock. The lock controller is connected to the lock switch connected to the main body, and the lock controller controls, when receiving the locking instruction or the unlocking instruction, the main body to perform a locking operation or an unlocking operation through the lock switch.

Abstract: A bifunctional fusion protein targeting CD47 and PD-L1, which belongs to the field of biomedicine and solves the problems that anti-PD-1/PD-L1 treatment has poor effect on low immunogenic tumors and anti-CD47 treatment has poor targeting properties. The fusion protein consists of a CD47-binding moiety and a PD-L1-binding moiety linked by means of a disulfide bond, can block both the binding of CD47 to SIRP? and the binding of PD-L1 to PD-1, not only activating macrophage phagocytosis of tumor cells and promoting antigen presentation in innate immunity, but also promoting tumor-specific T cell activation in acquired immunity, and has lower hematological toxicity. The fusion protein has better anti-tumor efficacy and hematological safety than anti-PD-L1 or anti-CD47 therapy alone, and animals from which a tumor has disappeared after the treatment of the fusion protein produce immunity against re-inoculation of the same tumor cell.

Abstract: A light-modulating element, a backlight module, a display device and a method for controlling the same are provided. The light-modulating element includes a first substrate and a second substrate arranged opposite to each other, and a polymer dispersed liquid crystal layer located between the first substrate and the second substrate. The light-modulating element is divided into a plurality of light-modulating zones, and the light-modulating element further includes a first electrode and a second electrode located in each of the plurality of light-modulating zone. A plurality of first electrodes located in different light-modulating zones are independently arranged, and the first electrode and the second electrode are configured to drive a deflection of polymer dispersed liquid crystal molecules in polymer dispersed liquid crystal layer.

Abstract: A speed bump and a speed bump transportation system are provided. The speed bump comprises: a base; a cover disposed opposite to the base and configured to be movable relative to the base; an electric-power generation device associated with the cover to scavenge energy through the cover and convert the energy into electrical energy; a first detection device for detecting a force condition of the cover and sending a first detection signal to a communication device when the cover is pressed; the communication device electrically connected to the first detection device and for sending a first communication signal when receiving the first detection signal, wherein the electric-power generation device is electrically connected to the communication device and the first detection device respectively to supply electric-power to the communication device and the first detection device.

Abstract: The present disclosure provides a backlight module and a display device. The backlight module includes a back plate, a first film layer, and a bonding portion. The back plate includes a back plate body and a side plate, where the side plate is disposed at a periphery of the back plate body and extends from the periphery of the back plate body. The first film layer is located in the accommodation space and is disposed as the outermost surface of the backlight module, and includes a film layer body and a protruding portion protruding from a periphery of the film layer body, where a projection of the protruding portion at a plane of the backlight exceeds a projection of the side panel at a plane of the backlight. The bonding portion is disposed at an outer side of the side plate and bonding the protruding portion and the side plate.

Abstract: The present disclosure provides a backlight module and a display device. The backlight module includes a back plate, a first film layer, and a bonding portion. The back plate includes a back plate body and a side plate, where the side plate is disposed at a periphery of the back plate body and extends from the periphery of the back plate body. The first film layer is located in the accommodation space and is disposed as the outermost surface of the backlight module, and includes a film layer body and a protruding portion protruding from a periphery of the film layer body, where a projection of the protruding portion at a plane of the backlight exceeds a projection of the side panel at a plane of the backlight. The bonding portion is disposed at an outer side of the side plate and bonding the protruding portion and the side plate.

Abstract: The present disclosure relates to a backlight module. The backlight module includes a back plate, a circuit layer, a light source and a plurality of connecting leads. The back plate has a first surface and a second surface which are opposite to each other, wherein the back plate is provided with a plurality of through holes penetrating the first surface and the second surface. The circuit layer is disposed on the first surface to form a driving circuit for a light source. The light source is disposed on a surface of the circuit layer away from the back plate and formed integrally with the back plate. The plurality of connecting leads pass through the plurality of through holes one-to-one for connecting the circuit layer and a main circuit board.

Abstract: The present disclosure relates to a backlight module. The backlight module includes a back plate, a circuit layer, a light source and a plurality of connecting leads. The back plate has a first surface and a second surface which are opposite to each other, wherein the back plate is provided with a plurality of through holes penetrating the first surface and the second surface. The circuit layer is disposed on the first surface to form a driving circuit for a light source. The light source is disposed on a surface of the circuit layer away from the back plate and formed integrally with the back plate. The plurality of connecting leads pass through the plurality of through holes one-to-one for connecting the circuit layer and a main circuit board.

Abstract: The present disclosure relates to a speed bump and a speed bump transportation system. The speed bump comprises: a base; a cover disposed opposite to the base and configured to be movable relative to the base; an electric-power generation device associated with the cover to scavenge energy through the cover and convert the energy into electrical energy; a first detection device for detecting a force condition of the cover and sending a first detection signal to a communication device when the cover is pressed; the communication device electrically connected to the first detection device and for sending a first communication signal when receiving the first detection signal, wherein the electric-power generation device is electrically connected to the communication device and the first detection device respectively to supply electric-power to the communication device and the first detection device.

Abstract: Disclosed are a method for preparing a dabigatran etexilate intermediate, and an intermediate compound. The method for preparing a dabigatran etexilate intermediate 4 comprises: reacting a compound 3 with a C1-C3 alkyl alcohol solution of methylamine in an organic solvent, wherein, X=chlorine, bromine, or iodine. Also disclosed are an intermediate compound 3 and a preparation method thereof. The method for preparing a dabigatran etexilate intermediate of the present invention has the advantages of simple process, easy operation, high yield, and easy purification, thus being suitable for industrial production.

Abstract: Disclosed are a method for preparing a dabigatran etexilate intermediate, and an intermediate compound. The method for preparing a dabigatran etexilate intermediate 4 comprises; reacting a compound 3 with a C1-C3 alkyl alcohol solution of methylamine in an organic solvent, wherein, X=chlorine, bromine, or iodine. Also disclosed are an intermediate compound 3 and a preparation method thereof. The method for preparing a dabigatran etexilate intermediate of the present invention has the advantages of simple process, easy operation, high yield, and easy purification, thus being suitable for industrial production.

Abstract: The present invention provides a method of acquiring proteins with high affinity by computer-aided design, which comprises the steps of: 1) based on a known cocrystal structure of a complex of a protein and a target molecule, determining candidate mutation sites of the protein; 2) simulating amino acid mutations in candidate sites of the protein in turn by computer so as to acquire optimized structures; 3) searching out conformations of the optimized structures acquired in step 2) by computer; 4) analyzing the total energies and root mean square deviations of the conformations acquired in step 3), and then selecting conformations with minimized energy and less root mean square deviations to analyze binding energies binding to the target molecule and to acquire simulative structures; and 5) based on the simulative structures acquired in step 4), predicting and validating mutated proteins with high affinity.

Abstract: This invention discloses a kind of concentrated medium for large-scale culture of Chinese Hamster Ovary cell. The said medium comprises basic medium and high dose additives. This invention also discloses the method of adding the described concentrated medium in large-scale fed-batch culture of CHO cells.

Abstract: The present invention provides a humanized anti-human CD34 antibody and the preparation method thereof. The humanized anti-human CD34 antibody retains the affinity and specificity of its original murine-derived antibody. The antibody can be conjugated with magnetic nano materials to prepare immunomagnetic beads to screen marrow hemopoietic stem cells. It can effectively reduce the incidence rate of HAMA and improve the security of clinical transplantation of hemopoietic stem cells and can be used in treatment of certain malignant hematologic diseases and solid tumors.

Abstract: The present invention discloses the functional epitope of osteopontin; the anti-osteopontin monoclonal antibody and immune conjugate raising against the functional epitope and their use for preparing anti-tumor drug. The present invention also discloses the DNA sequence encoding the monoclonal antibody, the vector and host cell containing the DNA sequence. The monoclonal antibody and immune conjugate of present invention can also be used to detect OPN. Through inhibiting OPN, the monoclonal antibody or immune conjugate of present invention can remedy or respite autoimmune diseases and protect correlative tissues, so they can be used to remedy autoimmune diseases.

Abstract: Provided are functional epitopes of osteopontin (OPN), monoclonal antibodies that specifically bind to the epitopes, immunoconjugates comprising the monoclonal antibodies and use of the monoclonal antibodies or immunoconjugates for manufacturing a medicament for the treatment of tumor. Also provided are nucleotide sequences encoding the monoclonal antibodies and vectors and host cells comprising the sequences. The monoclonal antibodies or immunoconjugates can be used for detecting the OPN, blocking the promoting metastasis-signaling pathway mediated by OPN and preventing the development and metastasis of tumor, thereby inhibiting the tumor.

Abstract: This invention relates to monoclonal antibodies that recognize an antigen specific to melanocytic lesions. These antibodies are useful in methods of isolating melanoma cells and diagnosing melanocytic lesions. These antibodies are also useful for immunotherapy against melanoma.

Abstract: This invention relates to monoclonal antibodies that recognize an antigen specific to melanocytic lesions. These antibodies are useful in methods of isolating melanoma cells and diagnosing melanocytic lesions. These antibodies are also useful for immunotherapy against melanoma.