Abstract: The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction.

Abstract: The invention relates to compounds of formula (I): or a salt thereof, wherein R1, G, L1, L2, L3, and Y are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are inhibitors of one, or both of, ?v?1 integrin and ?v?6 integrin that are useful for treating fibrosis such as in nonalcoholic steatohepatitis (NASH), idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).

Abstract: The present invention relates to the technical field of medicine, and particularly to a lycorine derivative of Formula (I), and a pharmaceutically acceptable salt, a preparation method, a pharmaceutical composition and use thereof. The lycorine derivative has obvious antiviral activity and is useful in the treatment of viral diseases such as hand-foot-mouth disease.

Abstract: Provided are a method for generating a haptic feedback signal, an electronic device, and a storage medium. The method includes: acquiring an initial haptic feedback signal; mapping an initial haptic feedback signal from a time domain to a frequency domain to obtain an initial spectrogram of the initial haptic feedback signal in the frequency domain; adjusting an amplitude value of a harmonic component of any frequency band in the initial spectrogram to obtain a target spectrogram; and mapping a signal corresponding to the target spectrogram from the frequency domain to the time domain to obtain a target haptic feedback signal. In the present application, a large number of haptic feedback signals with different haptic feedback effects may be obtained by adjusting the amplitude value of the harmonic component of any frequency band in the initial spectrogram, thereby effectively improving the richness of the haptic feedback signals.

Abstract: A motor vibration method and a motor vibration device are provided. The motor vibration method includes: receiving a vibration instruction, and acquiring target environmental data by a preset sensor, wherein the target environmental data includes one or more of environmental noise data, acceleration data and/or pressure data; determining a first vibration signal according to the target environmental data; generating a target vibration signal according to the first vibration signal and a preset second vibration signal, wherein a first frequency of the first vibration signal is greater than a second frequency of the second vibration signal; and controlling the motor to vibrate according to the target vibration signal. The method combines a traditional vibration reminding effect and a sound reminding effect provided by adding the medium- and high-frequency signal, thereby enhancing the reminding efficiency by means of motor vibration and increasing the successful rate of message delivery.

Abstract: The invention relates to compounds of formula (A) and formula (I): or a salt thereof, wherein R1, R2, R10, R11, R12, R13, R14, R15, R16, q and p are as described herein. Compounds of formula (A), formula (I), and pharmaceutical compositions thereof are ?v?6 integrin inhibitors that are useful for treating fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).

Abstract: The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction.

Abstract: The present invention provides a driving voltage generation method of a linear motor, and linear motor driving voltage generation device performing same. The driving voltage voltage generation method of a linear motor includes the following. Define the displacement waveform of the linear motor’s vibrator within a preset period and the displacement waveform is an asymmetrical waveform. Calculate the voltage waveform corresponding to the linear motor in the preset period according to the displacement waveform. The present invention is designed to use the driving voltage generated by the driving voltage generation method to effectively control the linear motor to express the vibration effect in a specific direction.

Abstract: The invention relates to methods of therapy using compounds of formula (I) and formula (II): or a salt thereof, wherein R1, R2, R10, R11, R12, R13, R14, R15, R16, q and p are as described herein. Compounds of formula (II) and pharmaceutical compositions thereof are integrin inhibitors that are useful in therapy for a condition, for example, caused by or associated with an infectious agent, shock, pancreatitis, or trauma. The condition can include one or more of pulmonary fibrosis associated with rheumatoid arthritis or progressive familial intrahepatic cholestasis (PFIC).

Abstract: The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction.

Abstract: The present invention provides a linear motor driving voltage generation method and related devices. The object is to use the driving voltage generated by the driving voltage generation method to effectively control the linear motor to express the vibration effect in a specific direction. The method of an embodiment of the present invention includes: determining the system gain and current phase of the linear motor system, obtaining the target acceleration and amplitude of initial value of the linear motor, calculating the driving based on the target acceleration and the initial value amplitude, the system gain, and the current phase.

Abstract: The present invention provides a linear motor driving voltage generation method and related devices. It is designed to use the driving voltage generated by the driving voltage generation method to effectively control the linear motor to express the vibration effect in a specific direction. The method of the present invention includes: Define the displacement waveform of the linear motor’s vibrator within a preset period. The displacement waveform is an asymmetrical waveform. Calculate the voltage waveform corresponding to the linear motor in the preset period according to the displacement waveform. The present invention enables the user to perceive the vibration of the linear motor in a specific direction.

Abstract: The invention relates to compounds of formula (A) and formula (I): or a salt thereof, wherein R1, R2, R10, R11, R12, R13, R14, R15, R16, q and p are as described herein. Compounds of formula (A), formula (I), and pharmaceutical compositions thereof are ?v?6 integrin inhibitors that are useful for treating fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).

Abstract: Provided are novel compounds of Formula (I): pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of diseases and disorders mediated by ROR?. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I) and methods for their use in treating one or more inflammatory, metabolic, autoimmune and other diseases or disorders.

Abstract: The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction.

Abstract: A method and an apparatus for displaying information of a motor are provided. The method includes: acquiring a target category identifier of a target motor; determining a category parameter interface according to the target category identifier, and displaying the category parameter interface, wherein the category parameter interface displays a category parameter tag that prompts a user to enter parameter information corresponding to the category parameter tag; acquiring target parameter information entered by the user via the category parameter interface; and obtaining target display information corresponding to the target category identifier according to the target parameter information, and displaying the target display information.

Abstract: The invention relates to compounds of formula (I): or a salt thereof, wherein R1, G, L1, L2, L3, and Y are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are inhibitors of one, or both of, ?v?1 integrin and ?v?6 integrin that are useful for treating fibrosis such as in nonalcoholic steatohepatitis (NASH), idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).

Abstract: A method for adaptive motor control includes acquiring current parameters in an operation process of the motor at a current moment; determining a type of a region in which the motor operates at the current moment according to the current parameters; triggering a corresponding motor model according to the type of the region in which the motor operates at the current moment; and inputting the current parameters into the corresponding motor model, generating control parameters for motor operation according to the current parameters, and controlling the operation of the motor according to the control parameters for motor operation. An apparatus and a computer-readable storage medium are also disclosed. In comparison with the conventional motor control which uses the single nonlinear model, the motor control method disclosed herein can greatly improve the reliability of the control.

Abstract: A method and device for audio signal processing is provided. The method includes steps of: obtaining an inputted audio signal; parsing the audio signal to obtain at least one audio feature; determining at least one vibration feature corresponding to the at least one audio feature; and generating a vibration signal corresponding to the audio signal according to the at least one vibration feature. The inputted audio signal is automatically converted into a vibration signal by the vibration feature corresponding to the audio feature of the inputted audio signal, which can avoid errors caused by manual operation and make the vibration signal possess high versatility.

Abstract: The invention provides a vibration controlling method which amplifies a steady state voltage and generates a first voltage signal for controlling the vibrator to accelerate vibration to a target vibration amplitude lower than the steady state vibration amplitude, and then attenuates the startup voltage to the steady state voltage to generate a second voltage signal for controlling the vibrator to vibrate from the target vibration amplitude to the steady state vibration amplitude. Through the implementation of the invention, the steady state voltage is amplified and used as an excitation voltage of the acceleration section of vibrator vibration, and then it steadily decreases to the steady state voltage, which effectively shortens the acceleration time for the early stage of the vibrator vibration response and reduces the hysteresis of the vibrator vibration fed back to the user.