Abstract: The invention relates to a pharmaceutical cream preparation for topical application in the form of an oil-in-water (o/w) emulsion, containing the following constituents in the lipophilic phase: (i) an optionally substituted 1-phenyl-2-(1H)-pyridone compound or a pharmaceutically acceptable salt thereof, as an active ingredient, (ii) at least one surface-active solubilising agent having an HLB value between 15 and 20, (iii) at least one emulsifier having an HLB value between 8 and 15, and (iv) optionally other carrier materials and additives known per se selected from the group containing triglycerides, penetration amplifiers, preserving agents and anti-oxidants. The invention also relates to the use of the preparation as a topical cream preparation for the treatment or prophylaxis of skin diseases.