Patents by Inventor Yale E. Goldman
Yale E. Goldman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11568717Abstract: A system for playback of messages. Context appropriate messages for an environment may be played back. Messages may be user behavior interactive and subject to user behavior initiated message playback conditions. User generated environment events may be automatically analyzed and user behavior interactive messages may be automatically coordinated. An automated themed message playback apparatus may have a self-contained housing within which a stored themed message, an in situ user generated environment event sensor, and an automated themed message playback device are housed. User generated environment events may be automatically sensed in situ.Type: GrantFiled: January 17, 2020Date of Patent: January 31, 2023Assignee: Martigold Enterprises, LLCInventors: George Martin, Yale E. Goldman
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Patent number: 10921326Abstract: Provided are methods for labeling transfer RNA comprising replacing the uracil component of a dihydrouridine of said transfer RNA with a fluorophore. The disclosed methods may comprise fluorescent labeling of natural tRNAs (i.e., tRNAs that have been synthesized in a cell, for example, in a bacterium, a yeast cell, or a vertebrate cell) at dihydrouridine (D) positions, or fluorescent labeling of synthetic tRNAs. In another aspect, the present invention provides methods for assessing protein synthesis in a translation system comprise providing a tRNA having a fluorophore substitution for the uracil component of a dihydrouridine in a D loop of the tRNA; introducing the labeled tRNA into the translation system; irradiating the translation system with electromagnetic radiation, thereby generating a fluorescence signal from the fluorophore; detecting the fluorescence signal; and, correlating the fluorescence signal to one or more characteristics of the protein synthesis in the translation system.Type: GrantFiled: December 18, 2018Date of Patent: February 16, 2021Assignees: The Trustees of the University of Pennsylvania, Anima Biotech Inc.Inventors: Barry S. Cooperman, Zeev Smilansky, Yale E. Goldman, Dongli Pan
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Publication number: 20200152023Abstract: A system for playback of messages. Context appropriate messages for an environment may be played back. Messages may be user behavior interactive and subject to user behavior initiated message playback conditions. User generated environment events may be automatically analyzed and user behavior interactive messages may be automatically coordinated. An automated themed message playback apparatus may have a self-contained housing within which a stored themed message, an in situ user generated environment event sensor, and an automated themed message playback device are housed. User generated environment events may be automatically sensed in situ.Type: ApplicationFiled: January 17, 2020Publication date: May 14, 2020Inventors: George Martin, Yale E. Goldman
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Patent number: 10540863Abstract: A system for playback of messages. Context appropriate messages for an environment may be played back. Messages may be user behavior interactive and subject to user behavior initiated message playback conditions. User generated environment events may be automatically analyzed and user behavior interactive messages may be automatically coordinated. An automated themed message playback apparatus may have a self-contained housing within which a stored themed message, an in situ user generated environment event sensor, and an automated themed message playback device are housed. User generated environment events may be automatically sensed in situ.Type: GrantFiled: April 17, 2017Date of Patent: January 21, 2020Assignee: Martigold Enterprises, LLCInventors: George Martin, Yale E. Goldman
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Publication number: 20190120848Abstract: Provided are methods for labeling transfer RNA comprising replacing the uracil component of a dihydrouridine of said transfer RNA with a fluorophore. The disclosed methods may comprise fluorescent labeling of natural tRNAs (i.e., tRNAs that have been synthesized in a cell, for example, in a bacterium, a yeast cell, or a vertebrate cell) at dihydrouridine (D) positions, or fluorescent labeling of synthetic tRNAs. In another aspect, the present invention provides methods for assessing protein synthesis in a translation system comprise providing a tRNA having a fluorophore substitution for the uracil component of a dihydrouridine in a D loop of the tRNA; introducing the labeled tRNA into the translation system; irradiating the translation system with electromagnetic radiation, thereby generating a fluorescence signal from the fluorophore; detecting the fluorescence signal; and, correlating the fluorescence signal to one or more characteristics of the protein synthesis in the translation system.Type: ApplicationFiled: December 18, 2018Publication date: April 25, 2019Inventors: Barry S. Cooperman, Zeev Smilansky, Yale E. Goldman, Dongli Pan
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Patent number: 10203335Abstract: Provided are methods for labeling transfer RNA comprising replacing the uracil component of a dihydrouridine of said transfer RNA with a fluorophore. The disclosed methods may comprise fluorescent labeling of natural tRNAs (i.e., tRNAs that have been synthesized in a cell, for example, in a bacterium, a yeast cell, or a vertebrate cell) at dihydrouridine (D) positions, or fluorescent labeling of synthetic tRNAs. In another aspect, the present invention provides methods for assessing protein synthesis in a translation system comprise providing a tRNA having a fluorophore substitution for the uracil component of a dihydrouridine in a D loop of the tRNA; introducing the labeled tRNA into the translation system; irradiating the translation system with electromagnetic radiation, thereby generating a fluorescence signal from the fluorophore; detecting the fluorescence signal; and, correlating the fluorescence signal to one or more characteristics of the protein synthesis in the translation system.Type: GrantFiled: February 9, 2017Date of Patent: February 12, 2019Assignees: The Trustees of the University of Pennsylvania, Anima Cell MetrologyInventors: Barry S. Cooperman, Zeev Smilansky, Yale E. Goldman, Dongli Pan
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Publication number: 20170221320Abstract: A system for playback of messages. Context appropriate messages for an environment may be played back. Messages may be user behavior interactive and subject to user behavior initiated message playback conditions. User generated environment events may be automatically analyzed and user behavior interactive messages may be automatically coordinated. An automated themed message playback apparatus may have a self-contained housing within which a stored themed message, an in situ user generated environment event sensor, and an automated themed message playback device are housed. User generated environment events may be automatically sensed in situ.Type: ApplicationFiled: April 17, 2017Publication date: August 3, 2017Inventors: George Martin, Yale E. Goldman
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Publication number: 20170153242Abstract: Provided are methods for labeling transfer RNA comprising replacing the uracil component of a dihydrouridine of said transfer RNA with a fluorophore. The disclosed methods may comprise fluorescent labeling of natural tRNAs (i.e., tRNAs that have been synthesized in a cell, for example, in a bacterium, a yeast cell, or a vertebrate cell) at dihydrouridine (D) positions, or fluorescent labeling of synthetic tRNAs. In another aspect, the present invention provides methods for assessing protein synthesis in a translation system comprise providing a tRNA having a fluorophore substitution for the uracil component of a dihydrouridine in a D loop of the tRNA; introducing the labeled tRNA into the translation system; irradiating the translation system with electromagnetic radiation, thereby generating a fluorescence signal from the fluorophore; detecting the fluorescence signal; and, correlating the fluorescence signal to one or more characteristics of the protein synthesis in the translation system.Type: ApplicationFiled: February 9, 2017Publication date: June 1, 2017Inventors: Barry S. Cooperman, Zeev Smilansky, Yale E. Goldman, Dongli Pan
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Patent number: 9626843Abstract: A system for playback of messages. Context appropriate messages for an environment may be played back. Messages may be user behavior interactive and subject to user behavior initiated message playback conditions. User generated environment events may be automatically analyzed and user behavior interactive messages may be automatically coordinated. An automated themed message playback apparatus may have a self-contained housing within which a stored themed message, an in situ user generated environment event sensor, and an automated themed message playback device are housed. User generated environment events may be automatically sensed in situ.Type: GrantFiled: April 11, 2016Date of Patent: April 18, 2017Assignee: Martigold Enterprises, LLCInventors: George Martin, Yale E. Goldman
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Patent number: 9612244Abstract: Provided are methods for labeling transfer RNA comprising replacing the uracil component of a dihydrouridine of said transfer RNA with a fluorophore. The disclosed methods may comprise fluorescent labeling of natural tRNAs (i.e., tRNAs that have been synthesized in a cell, for example, in a bacterium, a yeast cell, or a vertebrate cell) at dihydrouridine (D) positions, or fluorescent labeling of synthetic tRNAs. In another aspect, the present invention provides methods for assessing protein synthesis in a translation system comprise providing a tRNA having a fluorophore substitution for the uracil component of a dihydrouridine in a D loop of the tRNA; introducing the labeled tRNA into the translation system; irradiating the translation system with electromagnetic radiation, thereby generating a fluorescence signal from the fluorophore; detecting the fluorescence signal; and, correlating the fluorescence signal to one or more characteristics of the protein synthesis in the translation system.Type: GrantFiled: June 3, 2014Date of Patent: April 4, 2017Assignees: The Trustees Of The University Of Pennsylvania, Anima Cell Metrology, Inc.Inventors: Barry S. Cooperman, Zeev Smilansky, Yale E. Goldman, Dongli Pan
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Publication number: 20160225237Abstract: A system for playback of messages. Context appropriate messages for an environment may be played back. Messages may be user behavior interactive and subject to user behavior initiated message playback conditions. User generated environment events may be automatically analyzed and user behavior interactive messages may be automatically coordinated. An automated themed message playback apparatus may have a self-contained housing within which a stored themed message, an in situ user generated environment event sensor, and an automated themed message playback device are housed. User generated environment events may be automatically sensed in situ.Type: ApplicationFiled: April 11, 2016Publication date: August 4, 2016Inventors: George Martin, Yale E. Goldman
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Patent number: 9392951Abstract: Catheter systems for measuring at least one electrical property, e.g., impedance, of cardiac tissue of a living being are disclosed. The system includes a catheter having a tip with a sensing electrode, a guard electrode and an electrical shield. The sensing electrode is arranged to engage the cardiac tissue and is coupled to circuitry for measuring the at least one electrical property of the cardiac tissue, shielding the sensing electrode from bulk blood adjacent the cardiac tissue. The measurement can gated to the cardiac cycle. Additional embodiments include multi-electrode sensor catheter tips for high density mapping. Moreover, such tips may be dynamically configurable, i.e., their electrodes can be variably assigned as sensor electrodes or guard electrodes by associated circuitry. Such multi-electrode configuration and reconfiguration can be gated to the cardiac cycle.Type: GrantFiled: February 4, 2015Date of Patent: July 19, 2016Assignees: Albert Einstein Healthcare Network, The Trustees of the University of PennsylvaniaInventors: Allan M. Greenspan, Yale E. Goldman
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Patent number: 9311837Abstract: A system for playback of messages. Context appropriate messages for an environment may be played back. Messages may be user behavior interactive and subject to user behavior initiated message playback conditions. User generated environment events may be automatically analyzed and user behavior interactive messages may be automatically coordinated. An automated themed message playback apparatus may have a self-contained housing within which a stored themed message, an in situ user generated environment event sensor, and an automated themed message playback device are housed. User generated environment events may be automatically sensed in situ.Type: GrantFiled: March 14, 2013Date of Patent: April 12, 2016Assignee: Martigold Enterprises, LLCInventors: George Martin, Yale E. Goldman
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Publication number: 20150293023Abstract: The present invention relates to systems and methods for measuring the rate of translation of a target protein in cells, which are based on the detection of translation of one or more predetermined codon pairs during synthesis of the target protein. The detection is provided by a FRET signal emitted from labeled tRNA molecules which are juxtaposed during synthesis of the protein.Type: ApplicationFiled: April 20, 2015Publication date: October 15, 2015Inventors: Zeev Smilansky, Barry S. Cooperman, Yale E. Goldman
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Publication number: 20150148642Abstract: Catheter systems for measuring at least one electrical property, e.g., impedance, of cardiac tissue of a living being are disclosed. The system includes a catheter having a tip with a sensing electrode, a guard electrode and an electrical shield. The sensing electrode is arranged to engage the cardiac tissue and is coupled to circuitry for measuring the at least one electrical property of the cardiac tissue, shielding the sensing electrode from bulk blood adjacent the cardiac tissue. The measurement can gated to the cardiac cycle. Additional embodiments include multi-electrode sensor catheter tips for high density mapping. Moreover, such tips may be dynamically configurable, i.e., their electrodes can be variably assigned as sensor electrodes or guard electrodes by associated circuitry. Such multi-electrode configuration and reconfiguration can be gated to the cardiac cycle.Type: ApplicationFiled: February 4, 2015Publication date: May 28, 2015Inventors: Allan M. Greenspan, Yale E. Goldman
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Patent number: 8977334Abstract: Catheter systems for measuring at least one electrical property, e.g., impedance, of cardiac tissue of a living being are disclosed. The system includes a catheter having a tip with a sensing electrode, a guard electrode and an electrical shield. The sensing electrode is arranged to engage the cardiac tissue and is coupled to circuitry for measuring the at least one electrical property of the cardiac tissue, shielding the sensing electrode from bulk blood adjacent the cardiac tissue. The measurement can gated to the cardiac cycle. Additional embodiments include multi-electrode sensor catheter tips for high density mapping. Moreover, such tips may be dynamically configurable, i.e., their electrodes can be variably assigned as sensor electrodes or guard electrodes by associated circuitry. Such multi-electrode configuration and reconfiguration can be gated to the cardiac cycle.Type: GrantFiled: November 27, 2013Date of Patent: March 10, 2015Assignees: Albert Einstein Healthcare Network, The Trustees of the University of PennsylvaniaInventors: Allan M. Greenspan, Yale E. Goldman
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Publication number: 20140329234Abstract: Provided are methods for labeling transfer RNA comprising replacing the uracil component of a dihydrouridine of said transfer RNA with a fluorophore. The disclosed methods may comprise fluorescent labeling of natural tRNAs (i.e., tRNAs that have been synthesized in a cell, for example, in a bacterium, a yeast cell, or a vertebrate cell) at dihydrouridine (D) positions, or fluorescent labeling of synthetic tRNAs. In another aspect, the present invention provides methods for assessing protein synthesis in a translation system comprise providing a tRNA having a fluorophore substitution for the uracil component of a dihydrouridine in a D loop of the tRNA; introducing the labeled tRNA into the translation system; irradiating the translation system with electromagnetic radiation, thereby generating a fluorescence signal from the fluorophore; detecting the fluorescence signal; and, correlating the fluorescence signal to one or more characteristics of the protein synthesis in the translation system.Type: ApplicationFiled: June 3, 2014Publication date: November 6, 2014Applicants: AMINA CELL METROLOGY, THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIAInventors: BARRY S. COOPERMAN, ZEEV SMILANSKY, YALE E. GOLDMAN, DONGLI PAN
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Publication number: 20140278434Abstract: A system for playback of messages. Context appropriate messages for an environment may be played back. Messages may be user behavior interactive and subject to user behavior initiated message playback conditions. User generated environment events may be automatically analyzed and user behavior interactive messages may be automatically coordinated. An automated themed message playback apparatus may have a self-contained housing within which a stored themed message, an in situ user generated environment event sensor, and an automated themed message playback device are housed. User generated environment events may be automatically sensed in situ.Type: ApplicationFiled: March 14, 2013Publication date: September 18, 2014Inventors: George Martin, Yale E. Goldman
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Patent number: 8785119Abstract: Provided are methods for labeling transfer RNA comprising replacing the uracil component of a dihydrouridine of said transfer RNA with a fluorophore. The disclosed methods may comprise fluorescent labeling of natural tRNAs (i.e., tRNAs that have been synthesized in a cell, for example, in a bacterium, a yeast cell, or a vertebrate cell) at dihydrouridine (D) positions, or fluorescent labeling of synthetic tRNAs. In another aspect, the present invention provides methods for assessing protein synthesis in a translation system comprise providing a tRNA having a fluorophore substitution for the uracil component of a dihydrouridine in a D loop of the tRNA; introducing the labeled tRNA into the translation system; irradiating the translation system with electromagnetic radiation, thereby generating a fluorescence signal from the fluorophore; detecting the fluorescence signal; and, correlating the fluorescence signal to one or more characteristics of the protein synthesis in the translation system.Type: GrantFiled: June 20, 2008Date of Patent: July 22, 2014Assignees: Anima Cell Metrology, The Trustees of the University of PennsylvaniaInventors: Barry S. Cooperman, Zeev Smilansky, Yale E. Goldman, Dongli Pan
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Publication number: 20140155722Abstract: Catheter systems for measuring at least one electrical property, e.g., impedance, of cardiac tissue of a living being are disclosed. The system includes a catheter having a tip with a sensing electrode, a guard electrode and an electrical shield. The sensing electrode is arranged to engage the cardiac tissue and is coupled to circuitry for measuring the at least one electrical property of the cardiac tissue, shielding the sensing electrode from bulk blood adjacent the cardiac tissue. The measurement can gated to the cardiac cycle. Additional embodiments include multi-electrode sensor catheter tips for high density mapping. Moreover, such tips may be dynamically configurable, i.e., their electrodes can be variably assigned as sensor electrodes or guard electrodes by associated circuitry. Such multi-electrode configuration and reconfiguration can be gated to the cardiac cycle.Type: ApplicationFiled: November 27, 2013Publication date: June 5, 2014Applicant: Albert Einstein Healthcare NetworkInventors: Allan M. Greenspan, Yale E. Goldman