Patents by Inventor Yale University
Yale University has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20130274303Abstract: The present disclosure relates to methods of treating a stimulant addiction of a patient comprising administering to a patient in need a therapeutically effective dose of a selective dopamine beta-hydroxylase inhibitor thereby decreasing stimulant reward, inducing aversion for the stimulant or preventing relapse in the patient. The disclosure further encompasses methods whereby a therapeutically effective dose of a selective dopamine beta-hydroxylase inhibitor is determined by: characterizing the genetic profile of the patient with respect to the gene encoding dopamine beta-hydroxylase, a polymorphism therein correlating to the level of endogenous dopamine beta-hydroxylase activity in the patient before administering the therapeutic agent.Type: ApplicationFiled: October 2, 2012Publication date: October 17, 2013Applicants: YALE UNIVERSITY, EMORY UNIVERSITYInventors: EMORY UNIVERSITY, YALE UNIVERSITY
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Publication number: 20130222385Abstract: A method, a system, and a computer program product for generating a three-dimensional representation of a scene within a three-dimensional space are disclosed. A plurality of two-dimensional planes to be positioned within the three-dimensional space are generated. The plurality of two dimensional planes include two-dimensional content that is capable of being modified. The generated two-dimensional planes are positioned within the three-dimensional space. The positioning of the planes is capable of being modified.Type: ApplicationFiled: December 4, 2012Publication date: August 29, 2013Applicant: Yale UniversityInventor: Yale University
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Publication number: 20130216581Abstract: Carbon nanotube (CNT)-based compositions for activating cellular immune responses are provided. The CNTs function as high surface area scaffolds for the attachment of T cell ligands and/or antigens. The CNT compositions function as artificial antigen-presenting cells (aAPCs) or as modular vaccines. The disclosed CNT aAPCs are efficient at activating T cells and may be used to activate T cells ex vivo or in vivo for adoptive or active immunotherapy.Type: ApplicationFiled: March 15, 2013Publication date: August 22, 2013Inventor: Yale University
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Publication number: 20130209468Abstract: The present invention relates to novel methods and compositions for increasing AMPK activity and glucose uptake comprising administering a macrophage migration inhibitory factor (MIF) pathway agonist in a subject in need thereof. The invention also relates to methods for selecting a subject for treatment with an agonist of MIF, identifying a subject at risk for developing a condition in which increased AMPK activity is desirable, and for predicting whether a subject is susceptible to a condition in which increased AMPK activity is desirable.Type: ApplicationFiled: January 28, 2013Publication date: August 15, 2013Applicant: Yale UniversityInventor: Yale University
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Publication number: 20130190355Abstract: Many GTPases such as Ras, Ral and Rho require post-translational farnestylation or geranylgeranylation for mediating malignant transformation. Dual farnesyltransferase (FT) (FTI) and geranylgeranyltransferase-I (GGT-1) inhibitors (GGTI) were developed as anticancer agents from based on an ethylenediamine scaffold. On the basis of a 4-fold substituted ethylenediamine scaffold, the inhibitors are structurally simple and readily derivatized, facilitating extensive structure-activity relationship studies. The most potent inhibitor is compound exhibited an in vitro hFTase IC50 value of 25 nM and a whole cell H-Ras processing IC50 value of 90 nM. Several of the inhibitors proved highly selective for hFTase over the related prenyltransferase enzyme geranylgeranyltransferase-I (GGTase-I).Type: ApplicationFiled: March 11, 2013Publication date: July 25, 2013Applicants: Yale University, H. Lee Moffitt Cancer Center and Research Institute, Inc.Inventors: H. Lee Moffitt Cancer Center and Research Institute, Inc., Yale University
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Publication number: 20130171157Abstract: Disclosed are NgR proteins and biologically active Nogo (ligand) protein fragments. Also disclosed are compositions and methods for modulating the expression or activity of the Nogo and NgR protein. Also disclosed are peptides which block Nogo-mediated inhibition of axonal extension. The compositions and methods of the invention are useful in the treatment of cranial or cerebral trauma, spinal cord injury, stroke or a demyelinating disease.Type: ApplicationFiled: March 7, 2013Publication date: July 4, 2013Applicant: YALE UNIVERSITYInventor: YALE UNIVERSITY
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Publication number: 20130143763Abstract: The method of the invention pertains to determining signal transduction activity in a tissue section by immunohistochemistry techniques. The expression level of the receptor of interest is determined as well as the expression levels of one or more effector molecules of the receptor signal transduction pathway. Furthermore a combined ratio of expression levels of effector molecules in subcellular compartments with the receptor expression was found to have prognostic significance.Type: ApplicationFiled: February 5, 2013Publication date: June 6, 2013Applicants: YALE UNIVERSITY, HISTORX, INC.Inventors: HistoRx, Inc., Yale University
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Publication number: 20130127981Abstract: A method, system and computer program product for efficiently distributing video content. A peer-to-peer network and a content distribution network are used in combination to distribute video content. A content distribution network relies on servers distributed across the Internet to achieve high quality content delivery at a high cost. A peer-to-peer network distributes content among peers without incurring server side cost but may experience poor performance. The peer-to-peer network and the content distribution network are leveraged in a manner that achieves high content delivery and low cost by allowing the peer-to-peer network to serve as much content as possible while using the content distribution network to bootstrap the content in the peer-to-peer network and using it as a fallback whenever the peer-to-peer network has insufficient bandwidth, insufficient quality or when the missing piece of video content in the video buffer of the client device has an immediate deadline.Type: ApplicationFiled: January 15, 2013Publication date: May 23, 2013Applicants: YALE UNIVERSITY, SPLENDORSTREAM, LLCInventors: SplendorStream, LLC, Yale University
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Publication number: 20130131438Abstract: The present invention includes systems and methods of using real-time neurofeedback to improve the correspondence between first-person experience and specific brain activation patterns in a manner that minimally affects the experience itself. The present invention provides meditators the ability to enhance their control over their own brain activity, such as posterior cingulate cortex (PCC) activation. The present invention also provides methods for treating a disease or disorder of a subject by measuring the subject's brain activity via fMRI, presenting a representation of the measured brain activity to the subject, and instructing the subject to reduce the represented brain activity by altering their meditative state. The present invention also provides a system and method of using fMRI neurofeedback to directly correlate subjective experience with neural activation.Type: ApplicationFiled: November 19, 2012Publication date: May 23, 2013Applicant: Yale UniversityInventor: Yale University
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Publication number: 20130127982Abstract: A method, system and computer program product for efficiently distributing video content. A peer-to-peer network and a content distribution network are used in combination to distribute video content. A content distribution network relies on servers distributed across the Internet to achieve high quality content delivery at a high cost. A peer-to-peer network distributes content among peers without incurring server side cost but may experience poor performance. The peer-to-peer network and the content distribution network are leveraged in a manner that achieves high content delivery and low cost by allowing the peer-to-peer network to serve as much content as possible while using the content distribution network to bootstrap the content in the peer-to-peer network and using it as a fallback whenever the peer-to-peer network has insufficient bandwidth, insufficient quality or when the missing piece of video content in the video buffer of the client device has an immediate deadline.Type: ApplicationFiled: January 15, 2013Publication date: May 23, 2013Applicants: YALE UNIVERSITY, SPLENDORSTREAM, LLCInventors: SPLENDORSTREAM, LLC, YALE UNIVERSITY
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Publication number: 20130101688Abstract: This invention provides herbal compositions useful for increasing the therapeutic index of chemotherapeutic compounds. This invention also provides methods useful for improving the quality of life of an individual undergoing chemotherapy. Furthermore, this invention improves the treatment of disease by increasing the therapeutic index of chemotherapy drugs by administering the herbal composition PHY906 to a mammal undergoing such chemotherapy.Type: ApplicationFiled: October 10, 2012Publication date: April 25, 2013Applicant: YALE UNIVERSITYInventor: YALE UNIVERSITY
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Publication number: 20130090405Abstract: The present invention relates to the development and fabrication of thin-film polymer nanocomposites containing vertically aligned nanomaterials, such as single-walled carbon nanotubes (SWNTs). In certain embodiments, the present invention utilizes liquid crystal mesophases of hexagonally packed cylindrical micelles that orient with their long axes parallel to an applied magnetic field, thereby directing the alignment of the nanomaterials, such as SWNTs, sequestered in the micellar cores. In certain embodiments, the mesophase may be a stable, single-phase material containing monomers that can be polymerized after nanotube alignment to form the nanocomposite polymer.Type: ApplicationFiled: October 11, 2012Publication date: April 11, 2013Applicant: Yale UniversityInventor: Yale University
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Publication number: 20130089862Abstract: The invention comprises methods for identifying mutations within the 3?UTR of genes that lead to increased risk or probability of developing cancer.Type: ApplicationFiled: October 16, 2012Publication date: April 11, 2013Applicant: YALE UNIVERSITYInventor: Yale University
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Publication number: 20130066050Abstract: The invention relates to various intraflagellar transport (IFT) polypeptides and the nucleic acids that encode them. The new IFT particle polypeptides and nucleic acids can be used in a variety of diagnostic, screening, and therapeutic methods.Type: ApplicationFiled: November 6, 2012Publication date: March 14, 2013Applicants: YALE UNIVERSITY, UNIVERSITY OF MASSACHUSETTSInventors: University of Massachusetts, Yale University
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Publication number: 20130026387Abstract: A system and method for trapping a charged particle is disclosed. A time-varying periodic multipole electric potential is generated in a trapping volume. A charged particle under the influence of the multipole electric field is confined to the trapping volume. A three electrode configuration giving rise to a 3D Paul trap and a four planar electrode configuration giving rise to a 2D Paul trap are disclosed.Type: ApplicationFiled: October 4, 2012Publication date: January 31, 2013Applicants: Yale University, University of Tennessee Research Foundation, UT-Battelle, LLCInventors: Yale University, UT-Battelle, LLC, University of Tennessee Research Foundation