Patents by Inventor Yali Dou

Yali Dou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PEPTIDOMIMETIC INHIBITORS OF THE WDR5-MLL INTERACTION
    Publication number: 20210130401
    Abstract: The present disclosure provides compounds represented by Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3a, R3b, R4a, R4b, R5a and R5b are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I for use to treat a condition, disease, or disorder responsive to inhibition of the WDR5 interaction with its binding partners including, but not limited to, the WDR5-MLL protein-protein interaction.
    Type: Application
    Filed: May 15, 2018
    Publication date: May 6, 2021
    Inventors: Shaomeng Wang, Yangbing Li, Hacer Karatas, Liu Liu, Jeanne Stuckey, Yali Dou, Liyue Huang, Atsunori Kaneshige
  • Inhibition of WDR5 interaction with its binding partners
    Patent number: 9233086
    Abstract: Peptidomimetics that inhibit the interaction between MLL1 and WDR5 are disclosed. Methods of inhibiting MLL1 activity and methods of treating cancers also are disclosed.
    Type: Grant
    Filed: June 14, 2011
    Date of Patent: January 12, 2016
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Shaomeng Wang, Hacer Karatas, Yali Dou, Elizabeth Townsend, Denzil Bernard
  • Cyclized peptidomimetic small molecule inhibitors of the WDR5 and MLL1 interaction
    Patent number: 8980838
    Abstract: Cyclic peptidomimetics that inhibit the interaction between MLL1 and WDR5 are disclosed. Methods of inhibiting MLL1 activity and methods of treating cancers also are disclosed.
    Type: Grant
    Filed: November 27, 2012
    Date of Patent: March 17, 2015
    Assignee: The Regents of the University of Michigan
    Inventors: Shaomeng Wang, Hacer Karatas, Yali Dou, Elizabeth Townsend, Denzil Bernard, Fang Cao
  • Inhibition of WDR5 Interaction with Its Binding Partners
    Publication number: 20110312997
    Abstract: Peptidomimetics that inhibit the interaction between MLL1 and WDR5 are disclosed. Methods of inhibiting MLL1 activity and methods of treating cancers also are disclosed.
    Type: Application
    Filed: June 14, 2011
    Publication date: December 22, 2011
    Inventors: Shaomeng Wang, Hacer Karatas, Yali Dou, Elizabeth Townsend, Denzil Bernard