Abstract: A contrast enhanced imaging method and system, under a first mode, include: transmitting ultrasonic waves at a first frame rate to a tissue containing micro-bubbles and receiving echo signals thereof to generate a first contrast enhanced image; transmitting ultrasonic waves at a second frame rate greater than the first frame rate and receiving echo signals thereof to generate a second contrast enhanced image; and generating a super-resolution image; and may, under a second mode, include: transmitting ultrasonic waves at a third frame rate greater than the first frame rate to the target tissue containing the contrast micro-bubbles and receiving echo signals thereof to generate a third contrast enhanced image; freezing the third contrast enhanced image; and generating a super-resolution image based on the echo signals of the third ultrasonic waves for a period of time before freezing. With the present disclosure, users can easily collect the data for super-resolution imaging.

Abstract: A biphenyl-containing diarylpyrimido compound of formula (I), which is prepared by reacting a 4-chloropyrimidine derivative with a biphenyl derivative in a solvent in the presence of a base. A pharmaceutically-acceptable salt of the compound (I) and a pharmaceutical composition containing the compound (I) or a pharmaceutically-acceptable salt thereof are also provided.

Abstract: A biphenyl-containing diarylpyrimido compound of formula (I), which is prepared by reacting a 4-chloropyrimidine derivative with a biphenyl derivative in a solvent in the presence of a base. A pharmaceutically-acceptable salt of the compound (I) and a pharmaceutical composition containing the compound (I) or a pharmaceutically-acceptable salt thereof are also provided.