Abstract: The present disclosure is related generally to computer network architectures for machine learning, and more specifically, to computer network architectures for the automated production and distribution of custom healthcare performance benchmarks for specific patient cohorts. Embodiments allow specification and automated production of benchmarks using any of many dozens of patient, disease process, facility, and physical location attributes. Embodiments may use an analytic module web application and a benchmark service module web application, with other architecture components. Embodiments may include a combination of third-party databases to generate benchmarks and to drive the forecasting models, including social media data, financial data, socio-economic data, medical data, search engine data, e-commerce site data, and other databases.

Abstract: The present invention provides an aspartase mutant, a recombinant expression vector and recombinant bacterium containing the aspartase mutant, and the use thereof, and belongs to the technical field of genetic engineering. The amino acid sequence of the aspartase mutant is as set forth in SEQ ID NO: 1. In the aspartase mutant of the present invention, on the basis of wild type aspartase (with an amino acid sequence as set out in SEQ ID NO: 3), glutamic acid at position 427 is mutated into glutamine. In the present invention, by mutating the amino acid residue at position 427 into glutamine, the polar environment near an active site is changed, and thus ammonia supply during substrate reaction is further facilitated, thereby improving an enzyme activity, enhancing the ability of the enzyme in synthesizing a ?-amino acid, and providing a practical and effective strategy for industrial production of the ?-amino acid.

Abstract: A pixel arrangement structure of display panel and a display apparatus, which are used to solve the technical problem of low pixel aperture ratio of an organic light emitting diode display panel. Herein, a pixel arrangement structure of display panel includes: a plurality of sub-pixels including a first sub-pixel, a second sub-pixel, and a third sub-pixel; where the first sub-pixel, the second sub-pixel, and the third sub-pixel have a polygonal structure with different numbers of sides, and distances between any adjacent two of the plurality of sub-pixels are equal.

Abstract: Embodiments in the present disclosure relate generally to computer network architectures for machine learning, artificial intelligence, and dynamic patient guidance. Embodiments automatically update patient guidance in the patient care plan, based on the effectiveness of the guidance to date, attributes of the patient, other updated information, ongoing experience of the network, and updated predictions of possible patient outcomes and metrics.

Abstract: Embodiments in the present disclosure relate generally to computer network architectures for machine learning, artificial intelligence, and automated improvement and regularization of forecasting models, providing rapid improvement of the models. Embodiments may generate such rapid improvement of the models either occasionally on demand, or periodically, or as triggered by events such as an update of available data for such forecasts. Embodiments may indicate, after the improvement of the models, that various web applications using the models may be rerun to seek improved results for the web applications. Embodiments may include a combination of third-party databases to drive the forecasting models, including social media data, financial data, socio-economic data, medical data, search engine data, e-commerce site data, and other databases.

Abstract: A computer network architecture for a pipeline of models with machine learning and artificial intelligence for healthcare outcomes is presented. A machine learning prediction module and an artificial intelligence learning model are in electronic communication with a web application, which is also in electronic communication with a user device. An expanding updating database supports automatically recalibrating, re-evaluating, and reselecting the evolving and improving algorithms.

Abstract: The present disclosure is related generally to computer network architectures for machine learning, and more specifically, to computer network architectures for the automated production and distribution of custom healthcare performance benchmarks for specific patient cohorts. Embodiments allow specification and automated production of benchmarks using any of many dozens of patient, disease process, facility, and physical location attributes. Embodiments may use an analytic module web application and a benchmark service module web application, with other architecture components. Embodiments may include a combination of third-party databases to generate benchmarks and to drive the forecasting models, including social media data, financial data, socio-economic data, medical data, search engine data, e-commerce site data, and other databases.

Abstract: The present invention provides methods and compositions for enhancing the efficiency of Agrobacterium-mediated transformation of host cells, such as plant cells, wherein the host cells overexpress light-dependent short hypocotyls 10 (LSH10) protein. The methods of the invention comprise Agrobacterium-mediated transfer of T-DNA to a plant cell, wherein the T-DNA contains a DNA of interest to be inserted into a plant genome at a homologous position.

Abstract: The invention discloses a one lumbar zero-profile fusion system, including a holder, opener and nailing machine. The fusion system contains a fuser body, front support block, rear support block and adjustable lever; the fuser body covers the upper fuser body I as well as lower fuser body II, matching with the upper fuser body I; both ends of the fuser body connect to the front support block and rear support block, both of which connect to an adjustable lever; the adjustable lever goes through the said fuser body; rear support block and fuser body are connected with a fixed plate; the left and right side of the fixed plate are equipped with oblong holes which are connected to the fuser body by screw axle; and, the holder is equipped with long circular projection matching with the said oblong hole.

Abstract: A minimally invasive screw with double threaded plugs is provided, for connecting to a connecting rod. The screw includes an inner threaded plug, an outer threaded plug, a lengthened arm connector, a press block and a pin with a hollow ball head. The connecting rod can be fixed to the lengthened arm connector via the press block, the inner and outer threaded plugs, to prevent the vertebral body from rotating and loss of intervertebral height when the vertebral body is distracted and pressurized.

Abstract: A minimally invasive screw with double threaded plugs is provided, for connecting to a connecting rod. The screw includes an inner threaded plug, an outer threaded plug, a lengthened arm connector, a press block and a pin with a hollow ball head. The connecting rod can be fixed to the lengthened arm connector via the press block, the inner and outer threaded plugs, to prevent the vertebral body from rotating and loss of intervertebral height when the vertebral body is distracted and pressurized.

Abstract: The present invention provides methods and compositions for enhancing the efficiency of Agrobacterium-mediated transformation of host cells, such as plant cells, wherein the host cells overexpress LSH10 protein. The methods of the invention comprise Agrobacterium-mediated transfer of T-DNA to a plant cell, wherein the T-DNA contains a DNA of interest to be inserted into a plant genome at a homologous position.

Abstract: The present invention relates to synthetic processes useful in the preparation of macrocyclic compounds of Formula (I) that are useful as inhibitors of the hepatitis C virus NS3 protease and have application in the treatment of conditions caused by the hepatitis C virus. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation.

Abstract: The present invention relates to a process for producing a hydrate of 3-(2,6-dichlorophenyl)-4-imino-7-[(2?-methyl-2?,3?-dihydro-1?H-spiro[cyclopropane-1,4?-isoquinolin]-7?-yl)amino]-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one (Compound A) or of a pharmaceutically acceptable salt of Compound A and a crystalline form of Compound A or of a pharmaceutically acceptable salt of Compound A, which are useful in the field of treatment of various cancers as a kinase inhibitor, especially as a Weel kinase inhibitor.

Abstract: The present invention relates to synthetic processes useful in the preparation of macrocyclic compounds of Formula (I) that are useful as inhibitors of the hepatitis C virus NS3 protease and have application in the treatment of conditions caused by the hepatitis C virus. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation.

Abstract: The present invention relates to a process for producing a hydrate of 3-(2,6-dichlorophenyl)-4-imino-7-[(2?-methyl-2?,3?-dihydro-1?H-spiro[cyclopropane-1,4?-isoquinolin]-7?-yl)amino]-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one (Compound A) or of a pharmaceutically acceptable salt of Compound A and a crystalline form of Compound A or of a pharmaceutically acceptable salt of Compound A, which are useful in the field of treatment of various cancers as a kinase inhibitor, especially as a Weel kinase inhibitor.

Abstract: This invention relates to salt forms of the compound N-[(2R)-1,4-dioxan-2-ylmethyl]-N-methyl-N?-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]sulfamide, an inhibitor of tyrosine kinases, in particular the receptor tyrosine kinase MET, that are useful in the treatment of cellular proliferative diseases, for example cancer, hyperplasias, restenosis, cardiac hypertrophy, immune disorders and inflammation. In particular, the invention relates to the sodium salt of N-[(2R)-1,4-dioxan-2-ylmethyl]-N-methyl-N?-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]sulfamide.

Abstract: The present invention relates to a process for producing crystalline trans-N-[1-(2-fluorophenyl)-S-pyrazoly]-3-ox-ospiro[6-azaisobenzofuran-1(3H),1?-cyclohexane]-4?-carboxamide and novel salts, hydrates and polymorphs thereof.

Abstract: The present invention is directed to a practical process for the preparation of an enamide (II) by palladium catalyzed coupling of a primary amide (IV) with a compound of structural formula (III), as shown below: As well as to crystalline forms of a compound produced by this process, in particular, an anhydrous crystal form, Form B, and crystalline solvates falling into three patterns, Type 1, Type 2, and Type 3, and crystalline intermediate compounds produced in the process. Still further, the present invention relates to the stereoselective reduction of the tetrasubstituted enamide (II) to the corresponding amide (I).

Abstract: The present invention is directed to a practical process for the preparation of an enamide (II) by palladium catalyzed coupling of a primary amide (IV) with a compound of structural formula (III), as shown below: As well as to crystalline forms of a compound produced by this process, in particular, an anhydrous crystal form, Form B, and crystalline solvates falling into three patterns, Type 1, Type 2, and Type 3, and crystalline intermediate compounds produced in the process. Still further, the present invention relates to the stereoselective reduction of the tetrasubstituted enamide (II) to the corresponding amide (I).