Patents by Inventor Yameng HE

Yameng HE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CRYSTALLINE HYDROCHLORIDE SALTS OF N-ETHYL-2-(5-FLUORO-1H-INDOL-3-YL)-N-METHYLETHAN-1-AMINE
    Publication number: 20250115552
    Abstract: The present disclosure relates to a crystalline salt selected from crystalline N-ethyl-2-(5-fluoro-1H-indol-3-yl)-N-methylethan-1-amine fumarate and crystalline N-ethyl-2-(5-fluoro-1H-indol-3-yl)-N-methylethan-1-amine hydrochloride, methods of preparing them, and uses thereof for treating mood disorders. In addition, the present disclosure relates to polymorphs of the aforementioned salts. Further, the present disclosure relates to an oil or amorphous form of N-ethyl-2-(5-fluoro-1H-indol-3-yl)-N-methylethan-1-amine, methods of preparing the same, and uses thereof for treating mood disorders.
    Type: Application
    Filed: October 29, 2024
    Publication date: April 10, 2025
    Applicant: Gilgamesh Pharmaceuticals, Inc.
    Inventors: Andrew Carry Kruegel, William Leong, Yameng He, Lauren MacEachern
  • CRYSTALLINE SALTS OF N-ETHYL-(5-FLUORO-1H-INDOL-3-YL)-N-METHYLETHAN-1-AMINE
    Publication number: 20250042851
    Abstract: The present disclosure relates to a crystalline N-ethyl-2-(5-fluoro-1H-indol-3-yl)-N-methylethan-1-amine salt selected from crystalline N-ethyl-2-(5-fluoro-1H-indol-3-yl)-N-methylethan-1-amine monophosphate, crystalline N-ethyl-2-(5-fluoro-1H-indol-3-yl)-N-methylethan-1-amine mono-p-tosylate, crystalline N-ethyl-2-(5-fluoro-1H-indol-3-yl)-N-methylethan-1-amine hemimalate, and crystalline N-ethyl-2-(5-fluoro-1H-indol-3-yl)-N-methylethan-1-amine monosuccinate, pharmaceutical compositions comprising same, and uses thereof for treating mood disorders.
    Type: Application
    Filed: October 17, 2024
    Publication date: February 6, 2025
    Applicant: Gilgamesh Pharmaceuticals, Inc.
    Inventors: Andrew Carry Kruegel, William Leong, Yameng He, Lauren MacEachern
  • Crystalline fumarate salts of n-ethyl-2-(5-fluoro-1H-indol-3-yl)-n-methylethan-1-amine
    Patent number: 12180158
    Abstract: The present disclosure relates to a crystalline salt selected from crystalline N-ethyl-2-(5-fluoro-1H-indol-3-yl)-N-methylethan-1-amine fumarate and crystalline N-ethyl-2-(5-fluoro-1H-indol-3-yl)-N-methylethan-1-amine hydrochloride, methods of preparing them, and uses thereof for treating mood disorders. In addition, the present disclosure relates to polymorphs of the aforementioned salts. Further, the present disclosure relates to an oil or amorphous form of N-ethyl-2-(5-fluoro-1H-indol-3-yl)-N-methylethan-1-amine, methods of preparing the same, and uses thereof for treating mood disorders.
    Type: Grant
    Filed: September 14, 2023
    Date of Patent: December 31, 2024
    Assignee: Gilgamesh Pharmaceuticals, Inc.
    Inventors: Andrew Carry Kruegel, William Leong, Yameng He, Lauren MacEachern
  • CRYSTALLINE HYDROCHLORIDE SALTS OF N-ETHYL-2-(5-FLUORO-1H-INDOL-3-YL)-N-METHYLETHAN-1-AMINE
    Publication number: 20240400509
    Abstract: The present disclosure relates to a crystalline salt selected from crystalline N-ethyl-2-(5-fluoro-1H-indol-3-yl)-N-methylethan-1-amine fumarate and crystalline N-ethyl-2-(5-fluoro-1H-indol-3-yl)-N-methylethan-1-amine hydrochloride, methods of preparing them, and uses thereof for treating mood disorders. In addition, the present disclosure relates to polymorphs of the aforementioned salts.
    Type: Application
    Filed: September 14, 2023
    Publication date: December 5, 2024
    Applicant: Gilgamesh Pharmaceuticals, Inc.
    Inventors: Andrew Carry Kruegel, William Leong, Yameng He, Lauren MacEachern
  • Crystalline hydrochloride salts of N-ethyl-2-(5-fluoro-1H-indol-3-yl)-N-methylethan-1-amine
    Patent number: 12157722
    Abstract: The present disclosure relates to a crystalline salt selected from crystalline N-ethyl-2-(5-fluoro-1H-indol-3-yl)-N-methylethan-1-amine fumarate and crystalline N-ethyl-2-(5-fluoro-1H-indol-3-yl)-N-methylethan-1-amine hydrochloride, methods of preparing them, and uses thereof for treating mood disorders. In addition, the present disclosure relates to polymorphs of the aforementioned salts.
    Type: Grant
    Filed: September 14, 2023
    Date of Patent: December 3, 2024
    Assignee: Gilgamesh Pharmaceuticals, Inc.
    Inventors: Andrew Carry Kruegel, William Leong, Yameng He, Lauren MacEachern
  • Crystalline salts of N-ethyl-(5-fluoro-1H-indol-3-yl)-N-methylethan-1-amine
    Patent number: 12129234
    Abstract: The present disclosure relates to a crystalline N-ethyl-2-(5-fluoro-1H-indol-3-yl)-N-methylethan-1-amine salt selected from crystalline N-ethyl-2-(5-fluoro-1H-indol-3-yl)-N-methylethan-1-amine monophosphate, crystalline N-ethyl-2-(5-fluoro-1H-indol-3-yl)-N-methylethan-1-amine mono-p-tosylate, crystalline N-ethyl-2-(5-fluoro-1H-indol-3-yl)-N-methylethan-1-amine hemimalate, and crystalline N-ethyl-2-(5-fluoro-1H-indol-3-yl)-N-methylethan-1-amine monosuccinate, pharmaceutical compositions comprising same, and uses thereof for treating mood disorders.
    Type: Grant
    Filed: September 14, 2023
    Date of Patent: October 29, 2024
    Assignee: Gilgamesh Pharmaceuticals, Inc.
    Inventors: Andrew Carry Kruegel, William Leong, Yameng He, Lauren MacEachern
  • SOLID FORMS, PHARMACEUTICAL COMPOSITIONS AND PREPARATION OF HETEROAROMATIC MACROCYCLIC ETHER COMPOUNDS
    Publication number: 20230322797
    Abstract: Provided herein are solid forms comprising a compound of formula (I), or a stereoisomer, or a mixture of stereoisomers thereof, or a pharmaceutically acceptable salt thereof. Also provided herein are methods of synthesizing a compound of formula (I), pharmaceutical compositions comprising the same, and methods of treating, preventing, and managing various disorders using the compositions provided herein.
    Type: Application
    Filed: April 6, 2023
    Publication date: October 12, 2023
    Inventors: Christopher G. F. COOPER, Baudouin GERARD, Joshua Courtney HORAN, Jason T. KROPP, Benjamin Stephen LANE, David James PEARSON, Lauren Ashley MACEACHERN, Yameng HE, Mandeep SINGH, Arkesh NARAYANAPPA