Abstract: A three-dimensional ultrasonic elliptical vibration cutting device has a two-dimensional ultrasonic vibration transducer, an asymmetric ultrasonic horn, and a cutter. The cutter is installed at the output end of the asymmetric ultrasonic horn, the two-dimensional ultrasonic vibration transducer is used for outputting ultrasonic longitudinal-flexural complex vibration, the asymmetric ultrasonic horn is used for converting and decomposing longitudinal vibration output by the two-dimensional ultrasonic vibration transducer into second-phase flexural vibration and longitudinal vibration, and outputting a three-dimensional ultrasonic elliptical vibration trajectory on the cutter in combination with first-phase flexural vibration output by the two-dimensional ultrasonic vibration transducer. A three-dimensional ultrasonic elliptical vibration trajectory is output in a double-excitation mode.

Abstract: Provided is a pH-sensitive membrane disruptive peptide having a structure as shown in formula (I) or a stereoisomer thereof or a pharmaceutically acceptable salt thereof, and a use thereof. The macromolecular material is hydrophobic and electrically neutral at normal physiological pH, and can self-assemble into nanoparticles with tight assembly and weak interaction with cell membranes. Under a slightly acidic pH condition, the macromolecular material can be protonated to form an amphiphilic structure composed of a hydrophobic domain and a cationic domain, which has strong interaction with the cell membranes and strong membrane disruptive activity, and thus can efficiently and highly selectively kill tumor cells.

Abstract: A combined grinding wheel for ultrasonic machining and the determine method thereof. The combined grinding wheel for ultrasonic machining comprises: an outer grinding ring, an upper end thereof having a center taper hole and a plurality of outer grinding ring water holes located in a circumferential outer side of the center taper hole; a connecting taper shank, the upper end thereof having a taper shank extending into an outer grinding ring cavity from the center taper hole and matching the tapered surface of the center taper hole; a connecting flange, located outside the shank portion and fixed on the inner wall of the upper end of the outer grinding ring cavity, and having a center tapered through hole; and an inner vibration unit, having a tapered surface matching the tapered surface of the center tapered through hole and a center hole connected with the connecting taper shank by means of a screw.

Abstract: A novel three-dimensional ultrasonic elliptical vibration cutting device, comprising has a two-dimensional ultrasonic vibration transducer, an asymmetric ultrasonic horn, and a cutter. The cutter is installed at the output end of the asymmetric ultrasonic horn, the two-dimensional ultrasonic vibration transducer is used for outputting ultrasonic longitudinal-flexural complex vibration, the asymmetric ultrasonic horn is used for converting and decomposing longitudinal vibration output by the two-dimensional ultrasonic vibration transducer into second-phase flexural vibration and longitudinal vibration, and outputting a three-dimensional ultrasonic elliptical vibration trajectory on the cutter in combination with first-phase flexural vibration output by the two-dimensional ultrasonic vibration transducer. A three-dimensional ultrasonic elliptical vibration trajectory is output in a double-excitation mode.

Abstract: An ultraflat and ultralow-friction metallic glass thin film is fabricated. The metallic glass thin film is a binary alloy, wherein a content of one metal element of the binary alloy is between 45 atomic % and 64 atomic %. The metallic glass thin film has an atomically smooth surface with a surface roughness Ra less than 0.1 nm and a total height of profile Rt less than 0.15 nm; the friction coefficient is below 1×10?2. Due to the metallic glass thin film being treated by ion bombardment, the metallic glass thin film is thermally ultrastable.

Abstract: An ultraflat and ultralow-friction metallic glass thin film is fabricated. The metallic glass thin film is a binary alloy, wherein a content of one metal element of the binary alloy is between 45 atomic % and 64 atomic %. The metallic glass thin film has an atomically smooth surface with a surface roughness Ra less than 0.1 nm and a total height of profile Rt less than 0.15 nm; the friction coefficient is below 1×10?2. Due to the metallic glass thin film being treated by ion bombardment, the metallic glass thin film is thermally ultrastable.

Abstract: The present disclosure provides a pH-sensitive membranolytic polymer material and a preparation method and application thereof. The pH-sensitive membranolytic polymer material has the structure shown in Formula (I). At normal physiological pH, the polymer material is hydrophobic neutral, and can be self-assembled into PEG coated nanoparticles with weak interaction with cell membrane; when the pH decreases, the polymer material can be protonated to form an amphiphilic structure consisting of hydrophobic domain and cationic domain, which has strong interaction with the cell membrane and strong membranolytic activity, so the polymer material can kill tumor cells or bacteria efficiently and selectively.

Abstract: A freezing support device and method for a large thin-walled part, which belongs to the technical field of machining support. The present invention realizes freezing support for a large thin-walled part by a freezing system and an auxiliary system, wherein the freezing system comprises a heating source, a freezing source, flexible films, support plates, etc., and the auxiliary system comprises a rotating device, a moving plate and guide rails. The present invention utilizes ice with a certain thickness formed on a support side of a machining area and supports a workpiece through the ice, and the ice is always used as a support along with the progress of machining to have an effect of follow-up support. The present invention simplifies a support structure, and has the advantages of low cost, no contamination to a machine tool, and convenient use; plays a function of clamping the workpiece.

Abstract: A combined grinding wheel for ultrasonic machining and the determine method thereof. The combined grinding wheel for ultrasonic machining comprises: an outer grinding ring, an upper end thereof having a center taper hole and a plurality of outer grinding ring water holes located in a circumferential outer side of the center taper hole; a connecting taper shank, the upper end thereof having a taper shank extending into an outer grinding ring cavity from the center taper hole and matching the tapered surface of the center taper hole; a connecting flange, located outside the shank portion and fixed on the inner wall of the upper end of the outer grinding ring cavity, and having a center tapered through hole; and an inner vibration unit, having a tapered surface matching the tapered surface of the center tapered through hole and a center hole connected with the connecting taper shank by means of a screw.

Abstract: A freezing support device and method for a large thin-walled part, which belongs to the technical field of machining support. The present invention realizes freezing support for a large thin-walled part by a freezing system and an auxiliary system, wherein the freezing system comprises a heating source, a freezing source, flexible films, support plates, etc., and the auxiliary system comprises a rotating device, a moving plate and guide rails. The present invention utilizes ice with a certain thickness formed on a support side of a machining area and supports a workpiece through the ice, and the ice is always used as a support along with the progress of machining to have an effect of follow-up support. The present invention simplifies a support structure, and has the advantages of low cost, no contamination to a machine tool, and convenient use; plays a function of clamping the workpiece.

Abstract: The disclosure provides a class of pH-sensitive, helix/random conformation switchable antimicrobial polypeptide (HRS-AMP) compositions as a single agent to selectively kill bacteria (e.g., H. pylori) under acidic condition in the stomach with diminished bacterial resistance compared to currently used antibiotics. Methods of treating bacterial infections in the stomach are also provided.

Abstract: The present disclosure discloses an ultrasonic cutting holder for a honeycomb core, including a holder, a swing mechanism, a transducer, a first-stage amplitude transformer, a second-stage amplitude transformer, an ultrasonic cutting tool, and an ultrasonic power transmission mechanism. The present disclosure provides an ultrasonic cutting holder for a honeycomb core with large amplitude output capacity and considering the interchangeability requirements among different vibration systems, which solves the problem of the applicability of ultrasonic cutting holder on the universal machine tool and improves the automation level of ultrasonic cutting.

Abstract: The present disclosure discloses an ultrasonic cutting holder for a honeycomb core, including a holder, a swing mechanism, a transducer, a first-stage amplitude transformer, a second-stage amplitude transformer, an ultrasonic cutting tool, and an ultrasonic power transmission mechanism. The present disclosure provides an ultrasonic cutting holder for a honeycomb core with large amplitude output capacity and considering the interchangeability requirements among different vibration systems, which solves the problem of the applicability of ultrasonic cutting holder on the universal machine tool and improves the automation level of ultrasonic cutting.

Abstract: The disclosure provides a class of pH-sensitive, helix/random conformation switchable antimicrobial polypeptide (HRS-AMP) compositions as a single agent to selectively kill bacteria (e.g., H. pylori) under acidic condition in the stomach with diminished bacterial resistance compared to currently used antibiotics. Methods of treating bacterial infections in the stomach are also provided.

Abstract: A method and apparatus of configuring a smart WiFi device, a device and a computer storage medium is provided. In the configuring method; a terminal determines the WiFi device to be configured; the terminal uses an external AP function of the WiFi device to establish a connection with the WiFi device; the terminal obtains configuration information; the terminal sends the configuration information to the WiFi device through the connection so that the WiFi device performs configuration according to the sent configuration information. A method and apparatus for maintaining a WiFi device, a device and a computer storage medium is provided where: a terminal determines the WiFi device to be maintained; the terminal uses an external AP function of the WiFi device to establish a connection; the terminal detects a cause of the fault of the WiFi; the terminal generates maintenance information about the cause of the fault.