Abstract: The invention provides for a method for screening compounds that bind to and modulate a histone acetyltransferase protein. The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a HAT-activating compound to a subject.

Abstract: A computer-implemented method comprises analyzing content sections on each of a plurality of open browser pages using natural language processing to identify one or more topics on each of the plurality of open browser pages; calculating a respective relevance score for each of the content sections; grouping each of the plurality of topics into one of a plurality of topic groups; calculating a respective group ranking for each of the plurality of topic groups based on the respective relevance score for each content section. The method further comprises, for each topic group, assigning the respective group ranking to all of the content sections corresponding to the respective topic group; and, for each of the plurality of open browser pages, selecting at least one content section having a highest group ranking and modifying a display of the respective open browser page to direct attention to the selected content section.

Abstract: Aspects of the present invention disclose a method, computer program product, and system for content rendering. The method includes one or more processors retrieving at least one user interface (UI) component from a Document Object Model (DOM) tree. The method further includes one or more processors determining a corresponding rendering priority level (RPL) for each of the at least one UI component. The method further includes, in response to determining that the corresponding RPL of a first UI component of the at least one UI component is above a first threshold, one or more processors rendering the first UI component.

Abstract: A novel structure of an opioid antagonist is provided. One of the exemplary compounds of the present disclosure has the structure of Formula (II). The present disclosure overcomes the discomfort of conventional opioid antagonist due to rapid absorption and improves the patient compliance thereof.

Abstract: The present disclosure relates to a compound of Formula I, or a geometric isomer, enantiomer, diastereomer, racemate, atropisomer, pharmaceutically acceptable salt, prodrug or solvate thereof. The present disclosure further relates to a composition comprising the compound of Formula (I). The compound and the composition described herein can be used to inhibit NADPH oxidase activity.

Abstract: A light emitting chip includes a first-type semiconductor layer, a light emitting layer, and a second-type semiconductor layer which are disposed in such order, a passivation layer, and a current spreading layer. The second-type semiconductor layer and the light emitting layer cooperate to form a mesa structure which partially exposes the first-type semiconductor layer. The mesa structure has a lateral surface over which the passivation layer is disposed. The current spreading layer is disposed in contact with the second-type semiconductor layer. A distance between peripheries of a contact surface of the current spreading layer and a top surface of the second-type semiconductor layer is not greater than 5 ?m. A method for producing the chip is also disclosed.

Abstract: A novel structure of an opioid antagonist is provided. One of the exemplary compounds of the present disclosure has the structure of Formula (II). The present disclosure overcomes the discomfort of conventional opioid antagonist due to rapid absorption and improves the patient compliance thereof.

Abstract: The present application provides a compound in formula III, and further provides a use of the compound in the synthesis of a Brivaracetam intermediate and a crude drug, and a synthesis method. A raw material involved in the method of the present application is low in costs and easily available; (R)-4-propyl-dihydrofuran-2-ketone having high optical purity can be prepared; complicated separation and purification steps are avoided; costs are reduced, and the method is more applicable to industrial production.

Abstract: The present disclosure provides a benzene fused heterocyclic derivative of Formula (I): is a single or double bond; n is an integer of 0 or 1; A is —CH2—, —CH(OH)—, or —C(O)—; G is C or N; X is —CH2—, O, or —C(O)—; Y is alkyl, aryl, or heterocyclic alkyl optionally substituted with at least one substituent independently selected from a group consisting of: H, halogen, alkyl, alkyl substituted with at least one halogen, aryl, aryl substituted with at least one halogen, —NRy1Ry2, —ORy1, —Ry1C(O)Ry3, —C(O)Ry1, —C(O)ORy2, —C(O)ORy2Ry3, —NRy1C(O)Ry2, —NRy1C(O)NRy2Ry3, —NRy1C(O)ORy2Ry3, —NRy1C(O)Ry2ORy3, C(O)NRy1(Ry2Ry3), —C(O)NRy1(Ry2ORy1), —ORy2Ry3, and —ORy2ORy3, wherein each of Ry1 and Ry2 is independently selected from a group consisting of H, oxygen, alkyl, and aryl, and Ry3 is aryl optionally substituted with at least one halogen; Z is —NRz1Rz2, —NRz1Rz3, —ORz1, —ORz1Rz3, —C(O)Rz1Rz3, —C(O)ORz1Rz3, —NRz1C(O)Rz2Rz3, —NRz1C(O)ORz2Rz3, —C(O)NRz1Rz3, or ORz2ORz3, wherein each of Rz1 and Rz2 is independently sel

Abstract: Embodiments of the present invention provide methods, computer program products, and systems. Embodiments of the present invention can receive an application processing interface (API) invoke request for a service to be directed to an API management device. Embodiments of the present invention can then determine that there is a fast path to a service provider for the service requested by the API invoke request according to a fast path record in an accelerator. Embodiments of the present invention can then send the API invoke request to the service provider through the fast path based on the service provider's connection information.

Abstract: The present invention discloses a telescopic rod connector, which includes an outer sleeve, an inner sleeve and a screw rod. The screw rod has opposite a first end and a second end, and a rod body between them. The inner sleeve sleeves on the rod body and can rotate and slide along it, and the inner sleeve is provided with positioning convex strips. The outer sleeve includes a notch ring and a plurality of outer arc members extending from the notch ring. U-shaped notches are arranged between adjacent two the outer arc members; the outer sleeve is arranged on the outside of the inner sleeve and the notch ring is close to the first end, and the positioning convex strips are inserted into the U-shaped notches. The outer sleeve is rotated to drive the inner sleeve to slide along the rod body.

Abstract: Disclosed is a four-dimensional (4D: 3D+time) multi-plane broadband imaging apparatus capable of recording 3D multi-plane and multi-colour images simultaneously. The apparatus includes: one or more non-reentry quadratically distorted (NRQD) gratings which can produce a focal length and a spatial position corresponding to each diffraction order, thus simultaneously transmitting wavefront information between multiple object/image planes and a single image/object plane; a grism system which can limit chromatically-induced lateral smearing by creating a collimated beam in which the spectral components are laterally displaced; a lens system which is configured to adjust the optical path; and the optical detector(s). In an optical system, the multiple object/image planes, the lens system, the grism system, the NRQD grating(s), the optical detector(s) and the single image/object plane are located on the same optical axis.

Abstract: The present invention relates to an azetidine derivative for use as a Janus kinase (JAK) inhibitor, a drug composition comprising same, a preparation method therefor, and a use thereof in the treatment of JAK-related diseases comprising, for example, inflammatory diseases, autoimmune diseases, and cancers.

Abstract: A modular multilevel converter and a power electronic transformer is provided. The modular multilevel converter includes: a low-frequency AC to DC conversion module, comprising three branch circuits connected in parallel between output ends, each branch circuit being formed of multiple IGBT half-bridge circuits connected in series, and an electric coupling point of two adjacent IGBT half-bridge circuits in a middle position of the branch circuit being connected to a voltage input end Vin; a DC to high-frequency AC conversion module, connected between the output ends, the DC to high-frequency AC conversion module being formed of multiple IGBT half-bridge circuits connected in series, the DC to high-frequency AC conversion module having multiple sets of output ends. The MMC and power electronic transformer includes a smaller volume, lower cost and better stability in use.

Abstract: The invention provides for a method for screening compounds that bind to and modulate a histone acetyltransferase protein. The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a HAT-activating compound to a subject.

Abstract: Provided are a method for detecting a nucleic acid based on prokaryotic Argonaute protein and an application thereof. In particular, provided is a system for detecting a target nucleic acid molecule. The system comprises guide ssDNA, a gene-editing enzyme Pyrococcus furiosus Argonaute (PfAgo), and a fluorescent reporter nucleic acid.

Abstract: A computer-implemented method comprises analyzing content sections on each of a plurality of open browser pages using natural language processing to identify one or more topics on each of the plurality of open browser pages; calculating a respective relevance score for each of the content sections; grouping each of the plurality of topics into one of a plurality of topic groups; calculating a respective group ranking for each of the plurality of topic groups based on the respective relevance score for each content section. The method further comprises, for each topic group, assigning the respective group ranking to all of the content sections corresponding to the respective topic group; and, for each of the plurality of open browser pages, selecting at least one content section having a highest group ranking and modifying a display of the respective open browser page to direct attention to the selected content section.

Abstract: The present disclosure discloses a remote login processing method, apparatus, device and storage medium for an unmanned vehicle, and relates to the technical field of remote control. The implementation method of the specific method includes: sending a login request to an unmanned vehicle terminal through a first communication channel in response to a the login request received from an operator, and waiting to receive a reply instruction returned by the unmanned vehicle terminal; returning the reply instruction to the operator through the second communication channel in response to the reply instruction received from the unmanned vehicle terminal, so that the operator logs in the unmanned vehicle terminal according to the reply instruction, where there is a persistent connection state that unidirectionally authenticated between the second communication channel and the unmanned vehicle terminal.

Abstract: The present disclosure discloses a method, an apparatus, an electronic device and a medium for acquiring map data, and relates to the field of intelligent transportation. A specific implementation solution is: determining a target areas of interest in a map, wherein the map is divided into at least two areas of interest; sending a data acquisition instruction to data acquisition terminals to acquire the map data in the target areas of interest; and receiving the map data fed back from the data acquisition terminal and updating the target areas of interest in the map according to the map data.