Abstract: A memantine paroxetine cocrystal salt and its preparation method, pharmaceutical composition and application thereof are provided. The cocrystal salt of the invention is memantine paroxetine sulfate hydrate. Its mechanism of action is 5-HT inhibitor and NMDA receptor antagonist. It is a multi-target drug. The preliminary pharmacokinetic experiments showed that the main pharmacokinetic parameters of cocrystal salt and memantine, such as T1/2, Tmax, Cmax and AUC(0-?), were significantly different. The results also showed that cocrystal salt could improve drug absorption, blood drug concentration, bioavailability and curative effect. This provides a material basis for reducing dosage and adverse drug reactions. In addition to that the cocrystal salt of this invention can be used as a multi-target drug, it can also combine with other drugs of different action mechanisms to form compound preparations or be used in combination, so as to obtain unexpected clinical efficacy.

Abstract: A compound represented by the following general formula is excellent in light emission properties. R1 and R2 each independently represent a fluorinated alkyl group, D represents a substituent in which Hammett's ?p value is negative, and A represents a substituent in which Hammett's ?p value is positive.

Abstract: Disclosed are Pear 1 and, serving as a target of fibrotic diseases, applications in a medicament for treating human Pear 1-related diseases. Also disclosed are a Pear 1-targeting antibody or a mutant of same or a composition comprising same and applications thereof. Disclosed are a humanized Pear 1 transgenic mice model, a construction method for same, and applications thereof. The technical solution of the present invention regulates fibroblast activation and has broad application prospects in treating fibrotic diseases and accompanying debilitating diseases.

Abstract: Devices are provided for field weakening control of a compressor, including the compressor and a main circuit unit providing power for the compressor. The devices include a compressor rotational speed obtaining unit, and a control unit that compares the rotational speed ? of the compressor with a rotational speed threshold ?1 of the compressor, and controls the main circuit unit according to comparison results. When the rotational speed ? is less than ?1, an output voltage of the main circuit unit is controlled at a fixed value. When the rotational speed ? is greater than or equal to ?1, the compressor is controlled not to enter the field weakening control temporarily and the output voltage of the main circuit unit is controlled to rise, the compressor is controlled to enter the field weakening control when the output voltage of the main circuit unit cannot continue to rise.

Abstract: A surge absorption circuit for a single-phase air conditioning system, including: an L line and an N line, where one end of each of the two is connected to a power source, and the other end of each is connected to one pin of a rectifier bridge; a common mode inductor, which includes a magnetic ring, and first and second common mode coils that are connected in series in the L line and the N line, respectively; a first surge absorption unit, which is connected to the side of the common mode inductor close to the power source and which comprises first and second varistors and a first discharge tube, where one end of each of the first and second varistors is connected to the L line and the N line respectively, and the other end of each is connected to each other and grounded by the first discharge tube.

Abstract: Devices are provided for field weakening control of a compressor, including the compressor and a main circuit unit providing power for the compressor. The devices include a compressor rotational speed obtaining unit, and a control unit that compares the rotational speed ? of the compressor with a rotational speed threshold ?1 of the compressor, and controls the main circuit unit according to comparison results. When the rotational speed ? is less than ?1, an output voltage of the main circuit unit is controlled at a fixed value. When the rotational speed ? is greater than or equal to ?1, the compressor is controlled not to enter the field weakening control temporarily and the output voltage of the main circuit unit is controlled to rise, the compressor is controlled to enter the field weakening control when the output voltage of the main circuit unit cannot continue to rise.

Abstract: A memantine paroxetine cocrystal salt and its preparation method, pharmaceutical composition and application thereof are provided. The cocrystal salt of the invention is memantine paroxetine sulfate hydrate. Its mechanism of action is 5-HT inhibitor and NMDA receptor antagonist. It is a multi-target drug. The preliminary pharmacokinetic experiments showed that the main pharmacokinetic parameters of cocrystal salt and memantine, such as T1/2, Tmax, Cmax and AUC(0-?), were significantly different. The results also showed that cocrystal salt could improve drug absorption, blood drug concentration, bioavailability and curative effect. This provides a material basis for reducing dosage and adverse drug reactions. In addition to that the cocrystal salt of this invention can be used as a multi-target drug, it can also combine with other drugs of different action mechanisms to form compound preparations or be used in combination, so as to obtain unexpected clinical efficacy.

Abstract: A compound having two or more donor groups differing in the structure and a linking group that links these donor groups, wherein the linking group is an aromatic group composed of one or more benzene rings optionally substituted with an alkyl group or a halogeno group, has good light-emitting characteristics.

Abstract: The present disclosure provides an IO circuit and an access control signal generation circuit for the IO circuit. In one implementation, the access control signal generation circuit includes: a bias module coupled with an IO port, for generating an access control signal according to an IO port signal and an IO control signal, where a voltage value of the access control signal is a maximum value of a voltage value of an IO port voltage division signal and a voltage value of the IO control signal, and the voltage value of the IO port voltage division signal is a percentage of a voltage value of the IO port signal; an access control module coupled with the bias module, the access control module configured to control cut-off or conduction when receiving the access control signal and the IO port signal and outputting a first interface signal; and a higher-selection module configured to generate a second interface signal according to an IO power source signal and the IO port signal.

Abstract: The present disclosure provides an IO circuit and an access control signal generation circuit for the IO circuit. In one implementation, the access control signal generation circuit includes: a bias module coupled with an IO port, for generating an access control signal according to an IO port signal and an IO control signal, where a voltage value of the access control signal is a maximum value of a voltage value of an IO port voltage division signal and a voltage value of the IO control signal, and the voltage value of the IO port voltage division signal is a percentage of a voltage value of the IO port signal; an access control module coupled with the bias module, the access control module configured to control cut-off or conduction when receiving the access control signal and the IO port signal and outputting a first interface signal; and a higher-selection module configured to generate a second interface signal according to an IO power source signal and the IO port signal.

Abstract: A compound represented by the following general formula is excellent in light emission properties. R1 and R2 each independently represent a fluorinated alkyl group, D represents a substituent in which Hammett's ?p value is negative, and A represents a substituent in which Hammett's ?p value is positive.

Abstract: A receiver includes a first transfer gate, a first inverter, a second inverter, a second transfer gate, a third inverter, and a fourth inverter connected in series, a first power supply supplying power to the first and second inverters, a second power supply supplying power to the third and fourth inverters, a third power supply supplying power to the second transfer gate, first and second signals having opposite logic levels for controlling the first transfer gate. The third power supply is significantly lower than the first or second power supply. The leakage current of the receiver is significantly reduced in the core when the second power supply remains on but the first power supply is turned off while the performance of the receiver remains the same.

Abstract: A receiver includes a first transfer gate, a first inverter, a second inverter, a second transfer gate, a third inverter, and a fourth inverter connected in series, a first power supply supplying power to the first and second inverters, a second power supply supplying power to the third and fourth inverters, a third power supply supplying power to the second transfer gate, first and second signals having opposite logic levels for controlling the first transfer gate. The third power supply is significantly lower than the first or second power supply. The leakage current of the receiver is significantly reduced in the core when the second power supply remains on but the first power supply is turned off while the performance of the receiver remains the same.

Abstract: Optical isomers of phenylpropionic acid drugs are a mixture having R-type optical isomer and S-type optical isomer at a ratio of 10:1-1:10 by weight, wherein the ratio of 1:1 is excluded. A use of the optical isomers includes that the R-type optical isomer is used for manufacturing anti-inflammatory and analgesic drugs and the mixture having the R-type optical isomer and the S-type optical isomer at a ratio of 10:1-1:10 by weight, wherein the ratio of 1:1 is excluded, is used for manufacturing anti-inflammatory and analgesic drugs. The therapeutic indexes of anti-inflammatory and analgesic drugs of the present optical isomers are all higher than those of the S-type optical isomers and the racemate.

Abstract: The present invention includes compositions including a polymer-peptide hybrid and one or more isolated polynucleotides, wherein the polymer of the polymer-peptide hybrid includes a neutral amphiphilic block copolymer, wherein the peptide of the polymer-peptide hybrid is covalently attached to the hydrophobic block of the amphiphilic block copolymer, and wherein the one or more isolated polynucleotides are complexed with the polymer-peptide hybrid via electrostatic interactions between the peptide of the polymer-peptide hybrid and the one or more polynucleotides. The present invention also includes methods of making and using such compositions.

Abstract: Provided are filomicelle nanocarrier systems for the controlled transport and bioselective delivery of encapsulatable, cytotoxic active agents contained therein, particularly anticancer agents. Further provided are methods for controlling destabilization of the filomicelle membrane and the resulting hydrolysis-triggered, controlled release of the active agent(s) encapsulated therein by controlling the blend ratio (mol %) of hydrolysable PEO-block copolymer of the hydrophilic component(s) and of the more hydrophobic PEO-block copolymer component(s), wherein bioselective release of the encapsulated cytotoxic agents is distributed intracellularly, and wherein lowered dosage of the drug was delivered to the non-tumor organs. Thus, the filomicelle system offers enhanced tumor-selective biodistribution of a drug, and a reduced toxicity of the encapsulated drug to other organs.

Abstract: Provided are thermo-responsive polymersomes, which display cold-controlled encapsulation near the physiological temperatures, and have a PDI less than 1.2. Morphology of the thermo-responsive polymersomes is a function of the weight fraction of the hydrophilic block in the block copolymer and the number average molecular weight (Mn) of the block copolymer. When the lower critical solution temperature (LCST) is at, or slightly above physiological temperature, the thermo-responsive block displays hydrophobic properties, such that the block copolymer self-assembles in aqueous solution to form a polymersome with the thermo-responsive block occupying the core of the polymersome and the hydrophilic block occupying the corona of the polymersome. Below the LCST, the thermo-responsive block displays hydrophilic properties, such that the polymersome dissociates, providing fast release of an active agent encapsulated therein.

Abstract: Provided is a method of controlling the release of at least one encapsulated active agent from a worm-like micelle, wherein each worm-like micelle comprises one or more amphiphilic block copolymers that self assemble in aqueous solution, without organic solvent or post assembly polymerization; wherein at least one of said amphiphilic molecules is a hydrophilic block copolymer and at least one of said amphiphilic molecules is a hydrophobic block copolymer which is hydrolyticaly unstable in the pH range of about 5 to about 7. The loaded worm-like micelles of the present invention are particularly suited for the stable and controlled transport, delivery and storage of materials, either in vivo or in vitro.