Abstract: The present invention relates to a humanized single-domain antibody or an antigen-binding fragment thereof targeting MSLN or PD-L1. The present invention also relates to a multispecific antibody, and particularly provides a multispecific antibody targeting CD3, a tumor-associated antigen and an immune checkpoint, wherein the multispecific antibody has good medication safety and anti-tumor efficacy. The present invention further relates to use of the single-domain antibody or the multispecific antibody in disease treatment.

Abstract: A first earbud obtains first gravity data collected by a first inertial detector; and when the first gravity data meets a first condition, the first earbud identifies that the first earbud is worn on a left ear, and executes a control event corresponding to a left earbud attribute; or when the first gravity data meets a second condition, the first earbud identifies that the first earbud is worn on a right ear, and executes a control event corresponding to a right earbud attribute. According to the method, the wearable device may identify that the wearable device is worn on the left ear or the right ear, and execute different control events based on that the wearable device is worn on the left ear or the right ear.

Abstract: Compositions and methods for treating or reducing the severity or likelihood of occurrence of a parasitic worm or helminth infection in a subject are described. The methods include administering to the subject a therapeutically effective amount of a recombinant bacterium expressing a crystal protein such as a Bacillus thuringiensis crystal protein (Cry). The crystal proteins may be full length, truncated, variant, or sub-variant Cry proteins. Examples of crystal proteins include Cry5B, Cry21, Cry14A, Cry6A, and Cry13A. The recombinant bacterium may be, for example, a Bacillus subtilis or other Gram-positive bacterium, for instance, a lactic acid fermenting bacterium such as Lactococcus or Lactobacillus. Related compositions and recombinant microorganisms are also described.

Abstract: Multi-scale footprinting of DNA-protein interactions is described. Multi-scale footprint scores may be generated based on chromatin accessibility data, the multi-scale footprint scores indicating protein binding to positions of a genome at different protein size scales. A deep learning model may be trained using the multi-scale footprint scores and corresponding DNA sequences. DNA-protein interactions for a DNA sequence of interest may be predicted using the trained deep learning model. The prediction may include generating sequence attribution scores for the DNA sequence of interest using the trained deep learning model and predicting transcription factor binding sites of the DNA sequence of interest based on the sequence attribution scores.

Abstract: The invention discloses a single-frame fringe pattern analysis method based on multi-scale generative adversarial network. A multi-scale generative adversarial neural network model is constructed and a comprehensive loss function is applied. Next, training data are collected to train the multi-scale generative adversarial network. During the prediction, a fringe pattern is fed into the trained multi-scale network where the generator outputs the sine term, cosine term, and the modulation image of the input pattern. Finally, the arctangent function is applied to compute the phase. When the network is trained, the parameters of the network do not need to manually tune during the calculation. Since the input of the neural network is only a single fringe pattern, the invention provides an efficient and high-precision phase calculation method for moving objects.

Abstract: Aspects of the technology relate to methods for identifying a therapeutic genomic target sequence that include perturbing a genomic locus using a gene editing system, deaminating one or more nucleotides of the genomic locus using a deaminase to produce a pattern of deamination at the genomic locus, and identifying a therapeutic genomic target sequence based on the pattern of deamination at the genomic locus.

Abstract: A robotic arm obstacle avoiding path planning method is provided. The method includes the following steps: step 1: simplifying the robotic arm model and obstacles, determining robotic arm joint points, and adopting virtual joint interpolation to interpolate connecting rods between adjacent joints; employing spherical bounding boxes at each joint point to envelop and replace the robotic arm model, enabling complete substitution for distance calculation when the robotic arm assumes any posture; step 2: adopting an eye-to-hand configuration to position the depth camera, acquiring in real time the point cloud information of the robotic arm and obstacles in the workspace, and using a robot real-time filtering package to filter out the point cloud information of the robotic arm itself.

Abstract: A display panel and manufacturing method therefor and a display device are provided. The display panel includes: a base substrate; an insulation layer arranged at a peripheral area of the base substrate; at least one encapsulation dam arranged on a surface of the insulation layer away from the base substrate, the encapsulation dam being located in the peripheral area of the base substrate and being arranged around the display area; and at least one groove disposed in the insulation layer, a projection of the at least one groove on the base substrate being located within on a projection of the encapsulation dam on the base substrate.

Abstract: An application of a GMC oxidoreductase gene associated with oil and protein quality of Gossypium hirsutum and the cDNA sequence SEQ ID NO: 1 and the genome sequence SEQ ID NO: 2 of the gene in tetraploid Gossypium hirsutum are provided. The gene is obtained by re-sequencing Gossypium hirsutum varieties and GWAS, and is significantly associated with the oil and protein content of cottonseed kernel in cotton. The SNP genotype of the gene is used to distinguish high-quality and low-quality haplotypes. The variety population is classified according to these two haplotypes, and statistical analysis is performed in combination with quality traits, which also proves that there is a significant correlation between GhGMC and the oil and protein content of cottonseed kernel in cotton.

Abstract: A call control method, a related apparatus, and a communication system are provided. The method may be applied to a wearable device that integrates a smartwatch and earphones. The smartwatch may be used as a control and management device of the earphones to control the earphones to play call audio on different electronic devices with a sound. A user may control, through the wearable device, a plurality of electronic devices to make or answer calls, and may listen to call audio of each electronic device through the earphones. According to the foregoing method, the user can conveniently control the plurality of electronic devices to make/answer calls, to improve call experience of the user.

Abstract: A robotic arm obstacle avoiding path planning method is provided. The method includes the following steps: step 1: simplifying the robotic arm model and obstacles, determining robotic arm joint points, and adopting virtual joint interpolation to interpolate connecting rods between adjacent joints; employing spherical bounding boxes at each joint point to envelop and replace the robotic arm model, enabling complete substitution for distance calculation when the robotic arm assumes any posture; step 2: adopting an eye-to-hand configuration to position the depth camera, acquiring in real time the point cloud information of the robotic arm and obstacles in the workspace, and using a robot real-time filtering package to filter out the point cloud information of the robotic arm itself.

Abstract: Embodiments of this application provide a wearable device including a wireless audio apparatus, to form a new product form in which the wearable device and the audio apparatus are integrated. In view of the new product form, embodiments of this application further provide a power-on/off method, an upgrade method, a method for restoring to factory settings, a pairing and connection method, a music playing control method, a call control method, a charging method, a device search method, and the like. In addition to providing new user experience, this application implements simple and efficient human-machine interaction. The wearable device and the audio apparatus may be treated as one device. The audio apparatus may be considered as a microphone and speaker of the wearable device, and the wearable device may alternatively serve as a display device and micro control center of the audio apparatus.

Abstract: A headset theme adaptation method is provided to automatically obtain related information such as a device model and a device identifier of a headset case protective cover through multi-end linkage between a mobile phone, a headset, the headset case protective cover, and a cloud server (for example, a server of a cloud theme market). A headset theme adapted to the protective cover is downloaded and applied based on the related information, to implement personalized experience of headset theme adaptation.

Abstract: This application discloses a character recognition method and apparatus, an electronic device, and a medium. The character recognition method includes: obtaining a character picture, where the character picture includes at least one character; inputting the character picture to a grouped convolutional neural network model for prediction, to obtain character sequence prediction information corresponding to the character picture; and obtaining, based on the character sequence prediction information, a character recognition result corresponding to the character picture.

Abstract: A low-density liquid-phase chip for Gossypium hirsutum L. based on targeted capture sequencing and use thereof provided. The low-density chip includes 908 SNP loci, where among the 908 SNP loci, 329 loci are significantly related to important agronomic traits, such as fiber quality, yield, and disease resistance of Gossypium hirsutum L., 14 loci are common plant transgenic detection loci, and 565 loci are other loci. This chip is adapted for use of detection of transgenic components in Gossypium hirsutum L. varieties, resource evaluation and lineage identification, seed purity identification, and genetic improvement of major agronomic traits of Gossypium hirsutum L. varieties.

Abstract: An antibody targeting CD3 or an antigen-binding fragment thereof, which has a moderate ability to activate T cells and can effectively reduce cell factor release. A multispecific antibody targeting CD3 and other antigens, such as tumor-associated antigens and/or immune checkpoint molecules, which can significantly reduce cytokine release while ensuring efficient and specific killing of target cells, and has a significantly improved safety. The present invention also relates to uses of the antibody targeting CD3 or the antigen-binding fragment thereof, and the multispecific antibody or a composition comprising same in disease treatment.

Abstract: A computer-implemented method includes receiving a viewer request for playing a video summary of a video, wherein the viewer request includes a length of the video summary, generating the video summary of the viewer-requested length comprising a set of frames selected from the video based on audience reviews of the video, and playing a video stream of the video summary.