Abstract: Cytotoxic T lymphocytes (CTLs) specific for antigenic peptides derived from IgE molecule can be generated in vitro by stimulating resting naive CD8 T cells with IgE peptides presented by artificial antigen presenting cells. The IgE specific CTLs lyse the target cells loaded with IgE peptides in vitro and inhibit antigen specific IgE response in vivo. In addition, adoptive transfer of the IgE specific CTL to an asthmatic mouse model can inhibit the development of lung inflammation and airway hypersensitivity. IgE specific CTL provides a treatment for allergic asthma and other IgE-mediated allergic diseases. Antigenic peptides identified from non-tumor self-antigens induce specific cytotoxic T lymphocyte (CTL) in vitro. The CTL induced by peptides identified from CD40L can kill activated CD4 T cells. In vitro generated CTL specific for CD40L inhibit CD4-dependent antibody responses of all isotypes in vivo.

Abstract: Cytotoxic T lymphocytes (CTLs) specific for antigenic peptides derived from IgE molecule can be generated in vitro by stimulating resting naive CD8 T cells with IgE peptides presented by artificial antigen presenting cells. The IgE specific CTLs lyse the target cells loaded with IgE peptides in vitro and inhibit antigen specific IgE response in vivo. In addition, adoptive transfer of the IgE specific CTL to an asthmatic mouse model can inhibit the development of lung inflammation and airway hypersensitivity. IgE specific CTL provides a treatment for allergic asthma and other IgE-mediated allergic diseases. Antigenic peptides identified from non-tumor self-antigens induce specific cytotoxic T lymphocyte (CTL) in vitro. The CTL induced by peptides identified from CD40L can kill activated CD4 T cells. In vitro generated CTL specific for CD40L inhibit CD4-dependent antibody responses of all isotypes in vivo.

Abstract: Cytotoxic T lymphocytes (CTLs) specific for antigenic peptides derived from IgE molecule can be generated in vitro by stimulating resting naive CD8 T cells with IgE peptides presented by artificial antigen presenting cells. The IgE specific CTLs lyse the target cells loaded with IgE peptides in vitro and inhibit antigen specific IgE response in vivo. In addition, adoptive transfer of the IgE specific CTL to an asthmatic mouse model can inhibit the development of lung inflammation and airway hypersensitivity. IgE specific CTL provides a treatment for allergic asthma and other IgE-mediated allergic diseases. Antigenic peptides identified from non-tumor self-antigens induce specific cytotoxic T lymphocyte (CTL) in vitro. The CTL induced by peptides identified from CD40L can kill activated CD4 T cells. In vitro generated CTL specific for CD40L inhibit CD4-dependent antibody responses of all isotypes in vivo.

Abstract: Cytotoxic T lymphocytes (CTLs) specific for antigenic peptides derived from IgE molecule can be generated in vitro by stimulating resting naive CD8 T cells with IgE peptides presented by artificial antigen presenting cells. The IgE specific CTLs lyse the target cells loaded with IgE peptides in vitro and inhibit antigen specific IgE response in vivo. In addition, adoptive transfer of the IgE specific CTL to an asthmatic mouse model can inhibit the development of lung inflammation and airway hypersensitivity. IgE specific CTL provides a treatment for allergic asthma and other IgE-mediated allergic diseases. Antigenic peptides identified from non-tumor self-antigens induce specific cytotoxic T lymphocyte (CTL) in vitro. The CTL induced by peptides identified from CD40L can kill activated CD4 T cells. In vitro generated CTL specific for CD40L inhibit CD4-dependent antibody responses of all isotypes in vivo.

Abstract: Cytotoxic T lymphocytes (CTLs) specific for antigenic peptides derived from IgE molecule can be generated in vitro by stimulating resting naive CD8 T cells with IgE peptides presented by artificial antigen presenting cells. The IgE specific CTLs lyse the target cells loaded with IgE peptides in vitro and inhibit antigen specific IgE response in vivo. In addition, adoptive transfer of the IgE specific CTL to an asthmatic mouse model can inhibit the development of lung inflammation and airway hypersensitivity. IgE specific CTL provides a treatment for allergic asthma and other IgE-mediated allergic diseases. Antigenic peptides identified from non-tumor self-antigens induce specific cytotoxic T lymphocyte (CTL) in vitro. The CTL induced by peptides identified from CD40L can kill activated CD4 T cells. In vitro generated CTL specific for CD40L inhibit CD4-dependent antibody responses of all isotypes in vivo.

Abstract: Cytotoxic T lymphocytes (CTLs) specific for antigenic peptides derived from IgE molecule can be generated in vitro by stimulating resting naive CD8 T cells with IgE peptides presented by artificial antigen presenting cells. The IgE specific CTLs lyse the target cells loaded with IgE peptides in vitro and inhibit antigen specific IgE response in vivo. In addition, adoptive transfer of the IgE specific CTL to an asthmatic mouse model can inhibit the development of lung inflammation and airway hypersensitivity. IgE specific CTL provides a treatment for allergic asthma and other IgE-mediated allergic diseases. Antigenic peptides identified from non-tumor self-antigens induce specific cytotoxic T lymphocyte (CTL) in vitro. The CTL induced by peptides identified from CD40L can kill activated CD4 T cells. In vitro generated CTL specific for CD40L inhibit CD4-dependent antibody responses of all isotypes in vivo.

Abstract: The present invention provides water soluble triptolide derivatives of formula I, II, IIIa, and IIIb, which have high immunosuppressive activity and in which R1 and R2 have the same meanings as defined in claims. The present invention also provides chemically synthetic methods of the triptolide derivatives of formula I, II, IIIa, and IIIb, and the use of the triptolide derivatives in the treatment of autoimmune deficiency diseases and inflammatory diseases correlated with immunosuppression.

Abstract: The invention provides a printing method and apparatus, comprising a software application that works with proprietary printing utilities, and that may include one or more additional software components for adding additional printing technology. The invention also comprises an automatic print load-balancing component in a centralized or distributed raster image processing (RIP) printing environment that enables faster system performance over single or multiple processors.

Abstract: A multiple raster image processor (“RIP”) system is described that enables faster system performance over multiple processors, and includes a zero RIP feature consisting of a language interpreter sub-RIP that interprets a print instruction file but does not process the graphics rendering steps or the post-language processing operators. A skip RIP interprets selected pages in a way that skips all or most of the processing for that page. Pages to be skipped are scheduled for a different processor, thereby saving processing time and enabling the provision of a multiple processor RIP.

Abstract: A multiple raster image processor (“RIP”) system is described that enables faster system performance over multiple processors, and includes a zero RIP feature consisting of a language interpreter sub-RIP that interprets a print instruction file but does not process the graphics rendering steps or the post-language processing operators. A skip RIP interprets selected pages in a way that skips all or most of the processing for that page. Pages to be skipped are scheduled for a different processor, thereby saving processing time and enabling the provision of a multiple processor RIP.

Abstract: Cytotoxic T lymphocytes (CTLs) specific for antigenic peptides derived from IgE molecule can be generated in vitro by stimulating resting naive CD8 T cells with IgE peptides presented by artificial antigen presenting cells. The IgE specific CTLs lyse the target cells loaded with IgE peptides in vitro and inhibit antigen specific IgE response in vivo. In addition, adoptive transfer of the IgE specific CTL to an asthmatic mouse model can inhibit the development of lung inflammation and airway hypersensitivity. IgE specific CTL provides a treatment for allergic asthma and other IgE-mediated allergic diseases. Antigenic peptides identified from non-tumor self-antigens induce specific cytotoxic T lymphocyte (CTL) in vitro. The CTL induced by peptides identified from CD40L can kill activated CD4 T cells. In vitro generated CTL specific for CD40L inhibit CD4-dependent antibody responses of all isotypes in vivo.

Abstract: A multiple raster image processor (RIP) system is described that enables faster system performance over multiple processors, and includes a zero RIP feature consisting of a language interpreter sub-RIP that interprets a print instruction file but does not process the graphics rendering steps or the post-language processing operators. A skip RIP interprets selected pages in a way that skips all or most of the processing for that page. Pages to be skipped are scheduled for a different processor, thereby saving processing time and enabling the provision of a multiple processor RIP.

Abstract: A multiple raster image processor (RIP) system which enables faster system performance over multiple processors includes a zero RIP feature consisting of a language interpreter sub-RIP that interprets a print instruction file but does not process the graphics rendering steps or the post-language processing operators. The zero RIP discovers page related attributes for individual pages within a multipage job and reports any potential errors or warnings with the file. A thumb RIP consists of a very low resolution RIP that is used specifically for the creation of thumbnail images. A skip RIP interprets selected pages in a way that skips all or most of the processing for that page. Pages to be skipped are scheduled for a different processor, thereby saving processing time and enabling the provision of a multiple processor RIP. A rules based scheduler on an page/face or machine characteristic basis supports a dynamic assignment and assessment algorithm.

Abstract: A multiple raster image processor (RIP) system which enables faster system performance over multiple processors includes a zero RIP feature consisting of a language interpreter sub-RIP that interprets a print instruction file but does not process the graphics rendering steps or the post-language processing operators. The zero RIP discovers page related attributes for individual pages within a multipage job and reports any potential errors or warnings with the file. A thumb RIP consists of a very low resolution RIP that is used specifically for the creation of thumbnail images. A skip RIP interprets selected pages in a way that skips all or most of the processing for that page. Pages to be skipped are scheduled for a different processor, thereby saving processing time and enabling the provision of a multiple processor RIP. A rules based scheduler on an page/face or machine characteristic basis supports a dynamic assignment and assessment algorithm.