Abstract: Described herein are methods of using an anti-natriuretic peptide receptor 1 (NPR1) antibody or antigen binding fragment thereof for the treatment or prevention of a disease or disorder in a human, in particular for a disorder or a disease associated with natriuretic peptide receptor activity (including, but not limited to heart failure, e.g., HFrEF, HFmrEF, or HFpEF; or hypertension, e.g., resistant hypertension).

Abstract: The present invention relates to novel dopamine D2 receptor ligands. The invention further relates to functionally-biased dopamine D2 receptor ligands and the use of these compounds for treating or preventing central nervous system and systemic disorders associated with dysregulation of dopaminergic activity.

Abstract: The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, wherein U, J, V, X, R2a, R2b, R2c, R5 and t are as described herein. The present invention relates generally to inhibitors of histone deacetylase and to methods of making and using them. These compounds are useful for promoting cognitive function and enhancing learning and memory formation. In addition, these compounds are useful for treating, alleviating, and/or preventing various conditions, including for example, neurological disorders, memory and cognitive function disorders/impairments, extinction learning disorders, fungal diseases and infections, inflammatory diseases, hematological diseases, and neoplastic diseases in humans and animals.

Abstract: The present invention relates to novel dopamine D2 receptor ligands. The invention further relates to functionally-biased dopamine D2 receptor ligands and the use of these compounds for treating or preventing central nervous system and systemic disorders associated with dysregulation of dopaminergic activity.

Abstract: An array sensor and a method for forming and operating the same are provided. The array sensor includes: a sensor circuit including an array of pixel units that includes N rows of pixel units; and a driving circuit including at least N rows of shifting units; where the driving circuit further includes: a first global clearing signal line connected with odd rows of shifting units, a signal of which being applied to trigger the odd rows of shifting units to simultaneously turn on odd rows of pixel units, so that the odd rows of pixel units simultaneously discharge residual charge; and a second global clearing signal line connected with even rows of shifting units, a signal of which being applied to trigger the even rows of shifting units to simultaneously turn on even rows of pixel units, so that the even rows of pixel units simultaneously discharge residual charge.

Abstract: The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, wherein X1, X2, X3, X4, X5, W1, W2, W3, and W4 are as described herein. The present invention relates generally to inhibitors of histone deacetylase and to methods of making and using them. In one aspect, the invention relates to selective HDAC3 inhibitors useful for protecting ?-cells and improving insulin resistance. The selective HDAC3 inhibitors are also useful for promoting cognitive function and enhancing learning and memory formation.

Abstract: A method may be performed using a server. The method may include receiving an identity authentication request associated with a user, generating authentication information based on the identity authentication request, and generating candidate information based on the authentication information such that the authentication information is a subset of the candidate information. The candidate information may be displayed at a randomly selected location. The user may provide input through a graphic input interface to select the authentication information from among the candidate information.

Abstract: An array sensor and a method for forming and operating the same are provided. The array sensor includes: a sensor circuit including an array of pixel units that includes N rows of pixel units; and a driving circuit including at least N rows of shifting units; where the driving circuit further includes: a first global clearing signal line connected with odd rows of shifting units, a signal of which being applied to trigger the odd rows of shifting units to simultaneously turn on odd rows of pixel units, so that the odd rows of pixel units simultaneously discharge residual charge; and a second global clearing signal line connected with even rows of shifting units, a signal of which being applied to trigger the even rows of shifting units to simultaneously turn on even rows of pixel units, so that the even rows of pixel units simultaneously discharge residual charge.

Abstract: The present invention relates to novel dopamine D2 receptor ligands. The invention further relates to functionally-biased dopamine D2 receptor ligands and the use of these compounds for treating or preventing central nervous system and systemic disorders associated with dysregulation of dopaminergic activity.

Abstract: The present disclosure provides a method and a circuit for signal collection of an image sensor. The image sensor includes a plurality of pixels arranged in an array, and each of the plurality of pixels include a photodiode. The method for signal collection includes: performing signal collection row by row on the plurality of pixels in each signal collection period, wherein the signal collection period comprises at least one reset frame and at least one clear frame; applying a forward bias voltage to the photodiode of each of the plurality of pixels being collected in each reset frame; and applying a reverse bias voltage to the photodiode of each of the plurality of pixels being collected in each clear frame. The solution provided by the present disclosure can ensure a better clearing effect and eliminate the impact of ambient light on imaging, while shortening the signal collection period.

Abstract: An optical fingerprint sensor apparatus and an assembling method thereof are provided. The optical fingerprint sensor apparatus includes: a support frame structure having an opening therein, the opening penetrating through the support frame structure; an optical fingerprint sensor module disposed in the opening; a support plate disposed below the optical fingerprint sensor module and at the bottom of the support frame structure, wherein the support plate is fixedly connected to the bottom of the support frame structure; an elastic support member disposed between the optical fingerprint sensor module and the support plate, wherein the elastic support member is fixedly connected to the optical fingerprint sensor module and the support plate, respectively; and a self-luminous display panel disposed on the optical fingerprint sensor module and the support frame structure, wherein the self-luminous display panel and the support frame structure are fixedly connected.

Abstract: This application describes compositions, kits, and methods for removing contaminants from a protein preparation, for example a cell culture harvest comprising a recombinant protein. The methods described herein can enhance the performance of a later applied chromatographic purification step. The method generally involves contacting a protein preparation comprising a desired protein with a combination of allantoin, a cationic polymer, and a fatty acid, thereby causing the formation of solids and removal of the solids using a suitable process. Further treatment by contacting the treated sample with a chemically reactive surface further enhances results achieved by the first purification step.

Abstract: A method for intelligent inspections applicable in an electronic device scans a two-dimensional code, a scanned result including a first location information associated with the two-dimensional code. Next, the method for intelligent inspections transmits the scanned result to an inspection server to trigger the inspection server to return a command for a second location information of the electronic device. The second location information of the electronic device is given according to the command for the second location information of the electronic device. The second location information of the electronic device is transmitted to the inspection server. A related method for intelligent inspections applicable in an inspection server, and an electronic device using the method are also disclosed.

Abstract: An optical fingerprint sensor apparatus and an assembling method thereof are provided. The optical fingerprint sensor apparatus includes: a support frame structure having an opening therein, the opening penetrating through the support frame structure; an optical fingerprint sensor module disposed in the opening; a support plate disposed below the optical fingerprint sensor module and at the bottom of the support frame structure, wherein the support plate is fixedly connected to the bottom of the support frame structure; an elastic support member disposed between the optical fingerprint sensor module and the support plate, wherein the elastic support member is fixedly connected to the optical fingerprint sensor module and the support plate, respectively; and a self-luminous display panel disposed on the optical fingerprint sensor module and the support frame structure, wherein the self-luminous display panel and the support frame structure are fixedly connected.

Abstract: The present disclosure provides a method and a circuit for signal collection of an image sensor. The image sensor includes a plurality of pixels arranged in an array, and each of the plurality of pixels include a photodiode. The method for signal collection includes: performing signal collection row by row on the plurality of pixels in each signal collection period, wherein the signal collection period comprises at least one reset frame and at least one clear frame; applying a forward bias voltage to the photodiode of each of the plurality of pixels being collected in each reset frame; and applying a reverse bias voltage to the photodiode of each of the plurality of pixels being collected in each clear frame. The solution provided by the present disclosure can ensure a better clearing effect and eliminate the impact of ambient light on imaging, while shortening the signal collection period.

Abstract: An optical fingerprint module, comprising: a protective layer; an optical fingerprint sensor; a backlight source, said backlight source being located below the protective layer; the optical fingerprint sensor is stacked directly below the protective layer, or directly adhered to the bottom of the protective layer; the backlight source is located at a side of the optical fingerprint sensor. The present optical fingerprint module has a smaller size and better mechanical reliability.

Abstract: A self-luminous display pixel is provided, including: a self-luminous circuit which includes a self-luminous device, wherein the self-luminous display pixel further include an optical fingerprint sensing circuit, wherein the optical fingerprint sensing circuit comprises a first TFT device and a photosensitive device, and a channel layer of the first TFT device is disposed right under a portion of the photosensitive device. The self-luminous display pixel provides a fingerprint sensing function, and possesses an improved structure.

Abstract: The contact structure includes a first contact, a second contact, a first contact arm and a second contact arm. In an embodiment, the first contact arm includes at least two spring plates, arranged one on top of another and fixed at one end. The second contact is located on the second contact arm. The first contact is located on the spring plate, on a side of the first contact arm relatively closer to the second contact arm. The at least two spring plates, under a driving action, experience elastic deformation which causes the first contact and the second contact to come into contact with each other. The switch apparatus includes at least one driver and the contact structure of an embodiment. An embodiment of the present solution can reduce the number of contacts in a contact structure.