Patents by Inventor Yan LUAN
Yan LUAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11883503Abstract: Provided are compositions and methods for treating cancer comprising the use of a immunoconjugate in combination with a cytotoxic agent or cytotoxic therapy. The immunoconjugate in combination with a cytotoxic agent or cytotoxic therapy shows synergistic effects in cancer treatment.Type: GrantFiled: September 21, 2018Date of Patent: January 30, 2024Assignee: DINGFU BIOTARGET CO., LTD.Inventors: Ting Xu, Yan Luan, Shilong Fu, Songbing Qin, Jian Ding, Kai Fu
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Patent number: 11845806Abstract: Provided are proteinaceous heterodimers, pharmaceutical compositions, medicaments and/or kits comprising the proteinaceous heterodimers, methods for producing the proteinaceous heterodimers, and uses thereof.Type: GrantFiled: June 13, 2018Date of Patent: December 19, 2023Assignee: DINGFU BIOTARGET CO., LTD.Inventors: Ting Xu, Yan Luan, Jianjian Peng, Kai Fu, Meng Zhao, Xiaoxiao Wang
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Patent number: 11795230Abstract: The present disclosure provides an antibody, or an antigen binding fragment or variant thereof, which binds to CD27 and exhibits at least one of the following properties: specifically binds to CD27 with a KD of 10?8 M or less; activates and/or increases CD27 mediated NF-?B activity; stimulates CD4+ and/or CD8+ T cell proliferation; binds to human CD27 expressed on a cell surface; stimulates secretion of IFN-? by CD4+ and/or CD8+ T cells. The present disclosure also provides a method for preparing and using said antibody.Type: GrantFiled: April 13, 2018Date of Patent: October 24, 2023Assignee: DINGFU BIOTARGET CO., LTD.Inventors: Ting Xu, Yan Luan, Jianjian Peng, Kai Fu
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Patent number: 11529425Abstract: Provided is an immunoconjugate useful in inhibiting tumor growth, and a composition and/or protein mixture comprising the immunoconjugate. Also provided are methods for the production of the immunoconjugate, as well as pharmaceutical uses of the immunoconjugate in inhibiting tumor growth, including but not limited to treatment of cancers.Type: GrantFiled: September 6, 2018Date of Patent: December 20, 2022Assignee: Dingfu Biotarget Co., Ltd.Inventors: Ting Xu, Kai Fu, Yan Luan, Xiaojuan Liu, Jianjian Peng
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Patent number: 11357826Abstract: The present disclosure provides proteinaceous complexes, pharmaceutical compositions, medicaments and/or kits comprising the proteinaceous complexes, methods for producing the proteinaceous complexes, and uses thereof.Type: GrantFiled: August 21, 2019Date of Patent: June 14, 2022Assignee: DINGFU BIOTARGET CO., LTD.Inventors: Ting Xu, Yan Luan, Jianjian Peng, Shuli Ma, Meng Zhao, Xiaoxiao Wang, Hui Ma, Shilong Fu, Xiaolong Pan, Shanshan Ning
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Publication number: 20210179726Abstract: The present disclosure provides an antibody, or an antigen binding fragment or variant thereof, which binds to CD27 and exhibits at least one of the following properties: specifically binds to CD27 with a KD of 10?8 M or less; activates and/or increases CD27 mediated NF-?B activity; stimulates CD4+ and/or CD8+ T cell proliferation; binds to human CD27 expressed on a cell surface; stimulates secretion of IFN-? by CD4+ and/or CD8+ T cells. The present disclosure also provides a method for preparing and using said antibody.Type: ApplicationFiled: April 13, 2018Publication date: June 17, 2021Applicant: Dingfu Biotarget Co., Ltd.Inventors: Ting XU, Yan LUAN, Jianjian PENG, Kai FU
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Publication number: 20210162061Abstract: Provided is an immunoconjugate useful in inhibiting tumor growth, and a composition and/or protein mixture comprising the immunoconjugate. Also provided are methods for the production of the immunoconjugate, as well as pharmaceutical uses of the immunoconjugate in inhibiting tumor growth, including but not limited to treatment of cancers.Type: ApplicationFiled: September 6, 2018Publication date: June 3, 2021Inventors: Ting XU, Kai FU, Yan LUAN, Xiaojuan LIU, Jianjian PENG
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Patent number: 10875926Abstract: Disclosed are a fully human monoclonal antibody specifically binding to a CD137 or an antigen binding portion thereof. On one hand, provided are a CDR/variable region sequence of the antibody and an encoding nucleic acid sequence thereof; on the other hand, provided is a method for treating diseases using the antibody or the antigen binding portion thereof. a fully human monoclonal antibody specifically binding to a CD137 or an antigen binding portion thereof. On one hand, provided are a CDR/variable region sequence of the antibody and an encoding nucleic acid sequence thereof; on the other hand, provided is a method for treating diseases using the antibody or the antigen binding portion thereof.Type: GrantFiled: September 22, 2015Date of Patent: December 29, 2020Assignee: Dingfu Biotarget Co., Ltd.Inventors: Ting Xu, Yan Luan, Xiaoxiao Wang, Jianjian Peng, Shuli Ma, Hui Ma, Xiaolong Pan, Shilong Fu, Shanshan Ning, Yeqiong Fei, Meng Zhao
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Publication number: 20200354478Abstract: Provided are proteinaceous heterodimers, pharmaceutical compositions, medicaments and/or kits comprising the proteinaceous heterodimers, methods for producing the proteinaceous heterodimers, and uses thereof.Type: ApplicationFiled: June 13, 2018Publication date: November 12, 2020Applicant: DINGFU BIOTARGET CO., LTD.Inventors: Ting XU, Yan LUAN, Jianjian PENG, Kai FU, Meng ZHAO, Xiaoxiao WANG
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Publication number: 20200277350Abstract: Provided are proteinaceous heterodimers, pharmaceutical compositions, medicaments and/or kits comprising the proteinaceous heterodimers, methods for producing the proteinaceous heterodimers, and uses thereof.Type: ApplicationFiled: September 21, 2018Publication date: September 3, 2020Inventors: Ting XU, Yan LUAN, Jianjian PENG, Shilong FU
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Publication number: 20200268902Abstract: Provided are compositions and methods for treating cancer comprising the use of a immunoconjugate in combination with a cytotoxic agent or cytotoxic therapy. The immunoconjugate in combination with a cytotoxic agent or cytotoxic therapy shows synergistic effects in cancer treatment.Type: ApplicationFiled: September 21, 2018Publication date: August 27, 2020Inventors: Ting XU, Yan LUAN, Shilong FU, Songbing QIN, Jian DING, Kai FU
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Patent number: 10624974Abstract: The present application provides an anti-OX40 human antibody. In particular, a human antibody specifically binding to OX40 is obtained with yeast display screening, and the affinity of the antibody is improved with affinity maturation. The present application also provides a use of the antibody for the prevention or treatment of tumors.Type: GrantFiled: October 15, 2015Date of Patent: April 21, 2020Assignee: Dingfu Biotarget Co., Ltd.Inventors: Ting Xu, Yan Luan, Xiaoxiao Wang, Jianjian Peng, Shuli Ma, Hui Ma, Xiaolong Pan, Shilong Fu, Shanshan Ning, Yeqiong Fei, Meng Zhao
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Publication number: 20200069773Abstract: The present disclosure provides proteinaceous complexes, pharmaceutical compositions, medicaments and/or kits comprising the proteinaceous complexes, methods for producing the proteinaceous complexes, and uses thereof.Type: ApplicationFiled: August 21, 2019Publication date: March 5, 2020Applicant: DINGFU BIOTARGET CO., LTD.Inventors: Ting XU, Yan LUAN, Jianjian PENG, Shuli MA, Meng ZHAO, Xiaoxiao WANG, Hui MA, Shilong FU, Xiaolong PAN, Shanshan NING
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Patent number: 10471124Abstract: The present disclosure provides proteinaceous heterodimers, pharmaceutical compositions, medicaments and/or kits comprising the proteinaceous heterodimers, methods for producing the proteinaceous heterodimers, and uses thereof.Type: GrantFiled: November 10, 2015Date of Patent: November 12, 2019Assignee: DINGFU BIOTARGET CO., LTD.Inventors: Ting Xu, Yan Luan, Jianjian Peng, Shuli Ma, Meng Zhao, Xiaoxiao Wang, Hui Ma, Shilong Fu, Xiaolong Pan, Shanshan Ning
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Publication number: 20180339059Abstract: The present application provides an anti-OX40 human antibody. In particular, a human antibody specifically binding to OX40 is obtained with yeast display screening, and the affinity of the antibody is improved with affinity maturation. The present application also provides a use of the antibody for the prevention or treatment of tumors.Type: ApplicationFiled: October 15, 2015Publication date: November 29, 2018Inventors: Ting XU, Yan LUAN, Xiaoxiao WANG, Jianjian PENG, Shull MA, Hui MA, Xiaolong PAN, Shilong FU, Shanshan NING, Yeqiong FEI, Meng ZHAO
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Publication number: 20180282422Abstract: Disclosed are a fully human monoclonal antibody specifically binding to a CD137 or an antigen binding portion thereof. On one hand, provided are a CDR/variable region sequence of the antibody and an encoding nucleic acid sequence thereof; on the other hand, provided is a method for treating diseases using the antibody or the antigen binding portion thereof. a fully human monoclonal antibody specifically binding to a CD137 or an antigen binding portion thereof. On one hand, provided are a CDR/variable region sequence of the antibody and an encoding nucleic acid sequence thereof; on the other hand, provided is a method for treating diseases using the antibody or the antigen binding portion thereof.Type: ApplicationFiled: September 22, 2015Publication date: October 4, 2018Inventors: Ting XU, Yan LUAN, Xiaoxiao WANG, Jianjian PENG, Shuli MA, Hui MA, Xiaolong PAN, Shilong FU, Shanshan NING, Yeqiong FEI, Meng ZHAO
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Publication number: 20170340708Abstract: The present disclosure provides proteinaceous heterodimers, pharmaceutical compositions, medicaments and/or kits comprising the proteinaceous heterodimers, methods for producing the proteinaceous heterodimers, and uses thereof.Type: ApplicationFiled: November 10, 2015Publication date: November 30, 2017Inventors: Ting XU, Yan LUAN, Jianjian PENG, Shuli MA, Meng ZHAO, Xiaoxiao WANG, Hui MA, Shilong FU, Xiolong PAN, Shanshan NING