Abstract: Described is a locomotive implant for usage within a predetermined magnetic field. In one embodiment magnetohydrodynamics is used to generate thrust with a plurality of electrodes. In another embodiment, asymmetric drag forces are used to generate thrust.

Abstract: This invention is based on the discovery that many eye conditions associated with aging are mediated at least in part by cells bearing a senescent phenotype. Senescent cells accumulate with age, and express factors that contribute to the pathophysiology of age related conditions. The data show that in age-matched patients, the severity of age-related conditions correlates with the abundance of senescent cells, and that clearing senescent cells can help abrogate the condition. Small molecule drugs that remove senescent cells from affected tissue in the eye are provided that have special efficacy in treating ophthalmic conditions. They not only inhibit progression of the disease, they can also reverse some of the pathophysiology—such as neovascularization and vaso-obliteration—that lead to vision loss. These senolytic agents have an appropriate dose and specificity profile to be effective in the clinical management of previously intractable ophthalmic conditions.

Abstract: Disclosed herein are polynucleotides and the polypeptides encoded thereby and their use to increase biomass production by photosynthetic organisms. Also provided are photosynthetic organisms transformed by such polynucleotides and expressing such polypeptides.

Abstract: Provided herein are modified Rubisco large subunit proteins and nucleid acids encoding such proteins, as well as photosynthetic organism transformed with said nucleic acids and expressing said proteins. In certain embodiments, photosynthetic organisms containing said modified Rubisco large subunit proteins exhibit increased biomass production.

Abstract: Implantable devices and/or sensors can be wirelessly powered by controlling and propagating electromagnetic waves in a patient's tissue. Such implantable devices/sensors can be implanted at target locations in a patient, to stimulate areas such as the heart, brain, spinal cord, or muscle tissue, and/or to sense biological, physiological, chemical attributes of the blood, tissue, and other patient parameters. The propagating electromagnetic waves can be generated with sub-wavelength structures configured to manipulate evanescent fields outside of tissue to generate the propagating waves inside the tissue. Methods of use are also described.

Abstract: Implantable devices and/or sensors can be wirelessly powered by controlling and propagating electromagnetic waves in a patient's tissue. Such implantable devices/sensors can be implanted at target locations in a patient, to stimulate areas such as the heart, brain, spinal cord, or muscle tissue, and/or to sense biological, physiological, chemical attributes of the blood, tissue, and other patient parameters. In some embodiments, the implantable devices can include power management schemes that have one or more AC-DC conversion chains arranged and configured to rectify the induced alternating current or voltage into one or more energy domains. Methods of use are also described.

Abstract: A radio-frequency power receiving device has RF antennas connected to multiple controllable rectifying circuits to produce corresponding DC signals which are combined in a controllable switching network to produce a combined DC output. A control unit determines an amplitude control signal that controls each rectifying circuit and also determines switch control signals that control a switching network. The switching network controllably combines the direct-current signals to combine the multiple corresponding direct-current signals in series, in parallel, or in a combination of series and parallel.

Abstract: A closed-loop endoscopic capsule including a sensor recording biological information reflecting the inner condition of a gastrointestinal tract, an expander which is inflatable and holds the endoscopic capsule in the gastrointestinal tract, a medication releaser releasing medication for treatment, and a controller for processing the recorded biological information to generate control signals for the expander and the releaser. An endoscopic system that includes the endoscopic capsule, an external station for data processing, and a mobile device for human-machine interaction.

Abstract: Implantable devices and/or sensors can be wirelessly powered by controlling and propagating electromagnetic waves in a patient's tissue. Such implantable devices/sensors can be implanted at target locations in a patient, to stimulate areas such as the heart, brain, spinal cord, or muscle tissue, and/or to sense biological, physiological, chemical attributes of the blood, tissue, and other patient parameters. The propagating electromagnetic waves can be generated with sub-wavelength structures configured to manipulate evanescent fields outside of tissue to generate the propagating waves inside the tissue. Methods of use are also described.

Abstract: Implantable devices and/or sensors can be wirelessly powered by controlling and propagating electromagnetic waves in a patient's tissue. Such implantable devices/sensors can be implanted at target locations in a patient, to stimulate areas such as the heart, brain, spinal cord, or muscle tissue, and/or to sense biological, physiological, chemical attributes of the blood, tissue, and other patient parameters. The propagating electromagnetic waves can be generated with sub-wavelength structures configured to manipulate evanescent fields outside of tissue to generate the propagating waves inside the tissue. Methods of use are also described.

Abstract: Implantable devices and/or sensors can be wirelessly powered by controlling and propagating electromagnetic waves in a patient's tissue. Such implantable devices/sensors can be implanted at target locations in a patient, to stimulate areas such as the heart, brain, spinal cord, or muscle tissue, and/or to sense biological, physiological, chemical attributes of the blood, tissue, and other patient parameters. In some embodiments, the implantable devices can include power management schemes that have one or more AC-DC conversion chains arranged and configured to rectify the induced alternating current or voltage into one or more energy domains. Methods of use are also described.

Abstract: An apparatus can have a power supply circuit configured to receive, from an antenna, a first signal at a frequency exceeding a GHz, and including a rectifier circuit that is impedance matched to the antenna at the first frequency and that is configured to generate a supply voltage by rectifying the first signal at the first frequency. A signal generation circuit can be configured to use the supply voltage to generate a second signal at as higher frequency and to operate in two different power modes in response to a data signal. A transmitter circuit can be configured to use the supply voltage to create pulse at the higher frequency of the signal and in response to the data signal, and that includes an amplifier circuit configured to receive the data signal and provide an amplification of the data signal to the antenna.

Abstract: A radio-frequency power receiving device has RF antennas connected to multiple controllable rectifying circuits to produce corresponding DC signals which are combined in a controllable switching network to produce a combined DC output. A control unit determines an amplitude control signal that controls each rectifying circuit and also determines switch control signals that control a switching network. The switching network controllably combines the direct-current signals to combine the multiple corresponding direct-current signals in series, in parallel, or in a combination of series and parallel.

Abstract: Described herein are methods of making and using and apparatus for wirelessly communicating data and providing power, particularly from a location exterior to a body and to an implantable device disposed within a body with tissue. The described embodiments provide apparatus and methods for efficiently transfer data and power between an external transceiver and an (implanted) biomedical device. The method is to modulate power carrier, which wirelessly powers the device, using an asynchronous modulation scheme, such as amplitude shift keying (ASK) modulation, with minimal modulation depth in order to not disrupt the power flow. The digital data is encoded in the pulse width, eliminating the need for synchronization to the power carrier signal and further minimizing the power consumption necessary for data transfer. Additionally, a reverse backscatter method for obtaining data from the implant is described that has flexible, low power operation.

Abstract: Implantable devices and/or sensors can be wirelessly powered by controlling and propagating electromagnetic waves in a patient's tissue. Such implantable devices/sensors can be implanted at target locations in a patient, to stimulate areas such as the heart, brain, spinal cord, or muscle tissue, and/or to sense biological, physiological, chemical attributes of the blood, tissue, and other patient parameters. The propagating electromagnetic waves can be generated with sub-wavelength structures configured to manipulate evanescent fields outside of tissue to generate the propagating waves inside the tissue. Methods of use are also described.

Abstract: In certain embodiments, a coil circuitry component may be configured to detect RF signals from excited spins of at least a region of an organism, where the coil circuitry component comprises a RF detection coil and a detuning circuit for detuning the RF detection coil. A coil signal detection component may be configured to extract at least some of the RF signals detected by the coil circuitry component and to convert the extracted RF signals from analog signal to digital signals. An excitation estimation component may be configured to estimate the excitation pulses from an excitation source and to generate a control timing signal from the estimated excitation pulses to set a state of the detuning circuit. A wireless communication component may be configured to wirelessly transmit the converted RF signals, the estimated excitation pulses, and the control timing signal to an external computer system.

Abstract: The present invention is in the field of pharmaceuticals and chemical industries. In particular, one aspect of the present invention relates to methods for labeling, imaging and detecting the beta-amyloid (A?) peptides, oligomers, and fibrils in vitro and in vivo via magnetic resonance and florescence imaging by using modified carbazole-based fluorophores. A further aspect of the present invention relates to a method of reducing and preventing aggregation of beta-amyloid peptides for Alzheimer's disease (AD) as well as of treating and/or preventing Alzheimer's disease by using the modified carbazole-based fluorophore. The modified carbazole-based fluorophore according to an embodiment of the present invention is prepared by conjugating a carbazole-based fluorophore with magnetic nanoparticles to form a conjugate which is permeable to blood brain barrier of a subject being introduced therewith.

Abstract: In certain embodiments, a neural net computer system may include a plurality of computing nodes. At least some of the computing nodes are associated with a first layer of a neural net. At least some of the computing nodes are associated with a second layer of the neural net. The computing nodes may each include (i) one or more processors, (ii) memory, and (iii) a wireless or optical communication unit. For each of the computing nodes: (i) the processors, the memory, and the wireless or optical communication unit of the computing node are on-die components of the computing node, and (ii) the processors of the computing node (a) transmit signals to other ones of the computing nodes via the wireless or optical communication unit of the computing node and (b) receive signals from other ones of the computing nodes via the wireless or optical communication unit of the computing node.

Abstract: Implantable devices and/or sensors can be wirelessly powered by controlling and propagating electromagnetic waves in a patient's tissue. Such implantable devices/sensors can be implanted at target locations in a patient, to stimulate areas such as the heart, brain, spinal cord, or muscle tissue, and/or to sense biological, physiological, chemical attributes of the blood, tissue, and other patient parameters. The propagating electromagnetic waves can be generated with sub-wavelength structures configured to manipulate evanescent fields outside of tissue to generate the propagating waves inside the tissue. Methods of use are also described.

Abstract: A planar immersion lens can include any number of features. A planar immersion lens can be configured to control a phase profile of an incident wave by modulating the incident wave with sub-wavelength structures of varying impedances. The planar immersion lens can also be directly excited, with electronics or other subwavelength sources coupled to the planar immersion lens, to generate a wave with the desired phase profile. The planar immersion lens can include a plurality of metallic elements and passive elements disposed over a substrate. The passive elements can be selected, based on both the intrinsic and mutual impedances of the elements, to shape the spatial phase profile of the incident wave within this phase range. The phase gradient can be introduced along the incident material/refractive material interface to focus the incident wave into the refractive material having wave components at or beyond the critical angle. Methods are also provided.