Abstract: The present invention belongs to the technical field of biomedicine, and relates to a method for treating cancer by using an antibody-drug conjugate. In particular, the present invention relates to a use of an antibody drug conjugate represented by formula (I) and a pharmaceutically acceptable salt, a stereoisomer or a metabolite thereof, or a solvate of the foregoing in the manufacture of a medicament for preventing and/or treating a HER2-expressing, amplified or mutated cancer, wherein A is a group obtained by removing n amino groups from an antibody against HER2 or an active fragment or variant thereof; preferably, A is trastuzumab or a group obtained by removing n amino groups from Pertuzumab; n is selected from 1-10, such as 2-10 or 2-8; and preferably, n is an integer of 1, 2, 3, 4, 5, 6, 7 or 8.

Abstract: The present application relates to the technology field of assessment of aging state of oil paper insulation of the large power transformer and quantitative diagnostic, specifically estimating parameters of the circuit through the initial slope of the recovery voltage. It includes an improved mathematical model for solving parameters of the dielectric response equivalent circuit by using the peak of the recovery voltage, the peak time and the initial slope characteristics; transforming the identification of parameters of the equivalent circuit into a mathematical optimization problem, and then solving the mathematical optimization problem using a particle swarm algorithm. The design of the present application can significantly reduce the sampling data of the recovery voltage, and the measured data in the field and the calculated data of different capacity RVM experiments on real transformers have good consistency, which is conducive to the diagnosis of state of oil paper insulation of the transformer.

Abstract: Provided is a preparation method of an antibody-drug conjugate represented by Formula (I), or a pharmaceutically acceptable salt or stereoisomer thereof, or a solvate of the foregoing, wherein A, X, Y, L, D and a are as defined herein.

Abstract: The present invention provides an anti-ErbB2 antibody-drug conjugate, a composition comprising the conjugate, a method for preparing the conjugate, and use of the conjugate.

Abstract: Technical fields of building external wall decoration and material manufacturing, providing a mildewproof and antirot high-strength cement particle board and a preparation method thereof. The preparation method includes: (1) sequentially carbonizing and water-washing a shaving, and mixing the obtained carbonized shaving with a cement gelling agent, a curing agent aqueous solution and water to obtain a mixture; (2) molding the mixture to obtain a pre-molded material; and (3) sequentially curing and drying the pre-molded material to obtain the mildewproof and antirot high-strength cement particle board. Compared to ordinary cement particle board, which is not subjected to carbonization treatment and water-washing, the cement particle board of the present invention can effectively avoid mildew and rot, and can significantly improve the mechanical strength and durability thereof, helping to extend the service life of the cement particle board.

Abstract: Provided is a method for the prophylaxis or treatment of cancer, comprising administering to a patient in need thereof an antibody-drug conjugate represented by Formula (I), or a pharmaceutically acceptable salt or stereoisomer thereof, or a solvate of the foregoing, wherein A, X, Y, L, D and a are as defined herein.

Abstract: A solenoid valve includes a main valve, a first auxiliary valve, a second auxiliary valve, a main valve body, and an auxiliary valve body. The main and auxiliary valve bodies are axially parallel and detachably connected. The main valve is mounted on the main valve body, the first and second auxiliary valves are mounted on the auxiliary valve body, which is provided with an air inlet, a cylinder port and an air discharging port. The air inlet communicates with the main valve through a first air passage. The cylinder port is sequentially in communication with the first and second auxiliary valves and the main valve through a second air passage. The air discharging port sequentially communicates with the first and second auxiliary valves and the main valve through a third air passage. The main and second auxiliary valves are solenoid valves. The first auxiliary valve is a hand-operated valve.

Abstract: The present invention discloses a method for quick hot-press forming of laminated wood. The method includes: drying a machined small wood material to a moisture content of 5-8 wt %; gluing the dried small wood material, and assembling and laying the dried small wood material to be a square material or a sheet material, where an adhesive for the gluing is a water-soluble adhesive having a solid content of 45-60 wt %; clamping the square material or the sheet material through a three-dimensional metal clamp; sending the clamped square material or sheet material together with the clamp into a microwave heating machine for microwave heating to obtain a formed laminated wood, where the time from the gluing to the entry into the microwave heating machine is controlled to not exceed 15 min.

Abstract: Provided is a preparation method of an antibody-drug conjugate represented by Formula (I), or a pharmaceutically acceptable salt or stereoisomer thereof, or a solvate of the foregoing, wherein A, X, Y, L, D and a are as defined herein.

Abstract: A solenoid valve includes a main valve, a first auxiliary valve, a second auxiliary valve, a main valve body, and an auxiliary valve body. The main and auxiliary valve bodies are axially parallel and detachably connected. The main valve is mounted on the main valve body, the first and second auxiliary valves are mounted on the auxiliary valve body, which is provided with an air inlet, a cylinder port and an air discharging port. The air inlet communicates with the main valve through a first air passage. The cylinder port is sequentially in communication with the first and second auxiliary valves and the main valve through a second air passage. The air discharging port sequentially communicates with the first and second auxiliary valves and the main valve through a third air passage. The main and second auxiliary valves are solenoid valves. The first auxiliary valve is a hand-operated valve.

Abstract: Technical fields of building external wall decoration and outdoor furniture material manufacturing, providing a durable inorganic particle board and a preparation method and an application thereof. The preparation method includes: (1) mixing heat-vulcanized silicone rubber with an organic solvent to obtain a sealant solution; (2) mixing calcium chloride, sodium dodecyl sulfate and water to obtain a curing agent solution; (3) spraying the sealant solution on the surface of a shaving to mix with the curing agent solution, an inorganic adhesive and water to obtain a mixture; (4) sequentially laying and hot-pressing the mixture to obtain a pre-molded material; and (5) sequentially curing and drying the pre-molded material to obtain the durable inorganic particle board. The inorganic particle board prepared by the method of the present invention can be well applied to outdoor decoration and outdoor furniture manufacturing, has good durability and a long service life.

Abstract: Technical fields of building external wall decoration and material manufacturing, providing a mildewproof and antirot high-strength cement particle board and a preparation method thereof. The preparation method includes: (1) sequentially carbonizing and water-washing a shaving, and mixing the obtained carbonized shaving with a cement gelling agent, a curing agent aqueous solution and water to obtain a mixture; (2) molding the mixture to obtain a pre-molded material; and (3) sequentially curing and drying the pre-molded material to obtain the mildewproof and antirot high-strength cement particle board. Compared to ordinary cement particle board, which is not subjected to carbonization treatment and water-washing, the cement particle board of the present invention can effectively avoid mildew and rot, and can significantly improve the mechanical strength and durability thereof, helping to extend the service life of the cement particle board.

Abstract: A high-strength network structured nano-carrier material and a preparation method and application thereof. A nano-cellulose solution and graphene are mixed and ultrasonication is performed in an ultrasonic pulverizer to obtain a nano-cellulose/graphene suspension. The suspension with a phenolic resin adhesive is mixed and stirred to obtain a nano-cellulose/graphene/phenolic resin suspension. The nano-cellulose/graphene/phenolic resin suspension is injected into a mold. The mold is placed in a freeze dryer for freezing and vacuum dried in two stages to obtain a nano-cellulose/graphene/phenolic resin aerogel. The aerogel is preheated and cured in a muffle furnace, then subjected to a high-temperature thermal decomposition treatment in a tube furnace to obtain a nano-carrier material having a high-strength network structure. The preparation method is simple and convenient, low in cost, environmentally friendly and green.

Abstract: The present invention discloses a method for quick hot-press forming of laminated wood. The method includes: drying a machined small wood material to a moisture content of 5-8 wt %; gluing the dried small wood material, and assembling and laying the dried small wood material to be a square material or a sheet material, where an adhesive for the gluing is a water-soluble adhesive having a solid content of 45-60 wt %; clamping the square material or the sheet material through a three-dimensional metal clamp; sending the clamped square material or sheet material together with the clamp into a microwave heating machine for microwave heating to obtain a formed laminated wood, where the time from the gluing to the entry into the microwave heating machine is controlled to not exceed 15 min.

Abstract: The present application relates to a method for the prevention or treatment of an abnormal cell proliferative disease in a mammal, wherein the method comprises administering to the mammal an effective amount of a 4?-thionucleoside compound or a pharmaceutically acceptable salt, ester, hydrate, solvate thereof, or racemate thereof, or a mixture thereof.

Abstract: The present invention relates to a novel compound of 4?-thionucleoside, a preparation method therefor, a pharmaceutical composition comprising the same and an application thereof. Specifically, the present invention relates to a phosphamide derivative of 4?-thionucleoside, a preparation method therefor, a pharmaceutical composition comprising the same, a use thereof in the preparation of a medicine for preventing or treating abnormal cell proliferation diseases (for example, tumors or cancers and related diseases) or virus infectious diseases, and a method of using the same for preventing or treating abnormal cell proliferation diseases (for example, tumors or cancers and related diseases) or virus infectious diseases.

Abstract: The present invention relates to novel 2-acylaminothiazole derivatives. The present invention also relates to the preparation method for these novel 2-acylaminothiazole derivatives and intermediates thereof, and a pharmaceutical composition containing these compounds. Moreover, the present invention also relates to these novel 2-acylaminothiazole derivatives and the pharmaceutical composition containing the same for use in treating and/or preventing thrombopoietin receptor mediated diseases.

Abstract: The present invention provides an anti-ErbB2 antibody-drug conjugate, a composition comprising the conjugate, a method for preparing the conjugate, use of the conjugate.

Abstract: A high-strength network structured nano-carrier material and a preparation method and application thereof. A nano-cellulose solution and graphene are mixed and ultrasonication is performed in an ultrasonic pulverizer to obtain a nano-cellulose/graphene suspension. The suspension with a phenolic resin adhesive is mixed and stirred to obtain a nano-cellulose/graphene/phenolic resin suspension. The nano-cellulose/graphene/phenolic resin suspension is injected into a mold. The mold is placed in a freeze dryer for freezing and vacuum dried in two stages to obtain a nano-cellulose/graphene/phenolic resin aerogel. The aerogel is preheated and cured in a muffle furnace, then subjected to a high-temperature thermal decomposition treatment in a tube furnace to obtain a nano-carrier material having a high-strength network structure. The preparation method is simple and convenient, low in cost, environmentally friendly and green.

Abstract: The present invention relates to a novel compound of 4?-thionucleoside, a preparation method therefor, a pharmaceutical composition comprising the same and an application thereof. Specifically, the present invention relates to a phosphamide derivative of 4?-thionucleoside, a preparation method therefor, a pharmaceutical composition comprising the same, a use thereof in the preparation of a medicine for preventing or treating abnormal cell proliferation diseases (for example, tumors or cancers and related diseases) or virus infectious diseases, and a method of using the same for preventing or treating abnormal cell proliferation diseases (for example, tumors or cancers and related diseases) or virus infectious diseases.