Abstract: Multispecific binding molecules (MBMs) comprising an N-terminal scFv, a first Fab and a second Fab, MBM conjugates comprising the MBMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the MBMs and MBM conjugates, methods of using the MBMs, MBM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the MBMs, cells engineered to express the MBMs, and methods of producing MBMs.

Abstract: Multispecific binding molecules (MBMs) comprising an N-terminal scFv, a first Fab and a second Fab, MBM conjugates comprising the MBMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the MBMs and MBM conjugates, methods of using the MBMs, MBM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the MBMs, cells engineered to express the MBMs, and methods of producing MBMs.

Abstract: A method for controlling an interference torque for a vehicle is provided. The method is applied to a new energy vehicle including an electric motor and an engine, and includes steps of: arbitrating between a pedal torque of a driver and an interference torque required by ESP; performing an initial allocation on the electric motor and/or the engine in response to the pedal torque when the vehicle is in a hybrid drive mode, to meet an engine torque request while ensuring that the engine is operated at an optimal operation point; and determining, based on the initial allocation, whether the motor is capable of fully responding to the arbitrated torque, if so, controlling the motor to respond to the arbitrated torque in priority, otherwise controlling the engine and the motor to cooperatively respond to the arbitrated torque.

Abstract: An organic light emitting device, a preparation method therefor, and a display apparatus are provided. The organic light emitting device includes an anode, a cathode, and a light emitting layer and an electron transport layer arranged between the anode and the cathode. The electron transport layer is arranged between the light emitting layer and the cathode. The electron transport layer includes a first host material and a second host material. A mixing ratio of the first host material to the second host material of one side of the electron transport layer close to the light emitting layer is different from a mixing ratio of the first host material to the second host material of one side of the electron transport layer away from the light emitting layer.

Abstract: Disclosed herein is a method of treating a pancreatic cancer in a subject who is responsive to a platinum-based therapy. The method comprises administering to the subject an effective amount of a BET inhibitor and an effective amount of a PARP inhibitor. According to some embodiments of the present disclosure, the BET inhibitor is mivebresib, JQ1, or AZD5153, and the PARP inhibitor is rucaparib, veliparib, or olaparib.

Abstract: Disclosed herein is an isolated population of cardiomyocytes differentiated from human induced pluripotent stem cells (hiPSCs), wherein the isolated population of cardiomyocytes comprises genomic deletions in HCN1 and HCN4 genes. According to some embodiments of the present disclosure, the isolated population of cardiomyocytes further comprises genomic deletions in HCN2 and HCN3 genes. Also disclosed herein are methods of producing the isolated population of cardiomyocytes, and methods of treating subjects suffering from cardiac diseases by administering the isolated population of cardiomyocytes to the subjects.

Abstract: A fluorocarbon/palladium/magnesium-scandium hydrogen-chromic film and a preparation method thereof are provided. The film includes a magnesium-scandium composite film layer, a palladium catalytic layer, and a fluorocarbon film layer that are sequentially arranged on a substrate. The preparation method includes: growing the magnesium-scandium composite film layer on the substrate first, then growing the palladium catalytic layer in situ on the magnesium-scandium layer, and finally depositing the fluorocarbon film layer on Pd. According to the present invention, the catalytic effect of palladium is utilized to promote reversible conversion between hydrogen and hydrogen atoms during hydrogen absorption and dehydrogenation stages, and a composite scandium element is added to accelerate diffusion of the hydrogen atoms in a magnesium matrix and accelerate formation and decomposition of a hydride, such that the film can be repeatedly and rapidly switched between a reflective state and a transparent state.

Abstract: A mobile edge computing (MEC) task unloading method with a cache mechanism includes: S1: establishing a task unloading total delay model with a cache mechanism and a mobile device-side total energy consumption model based on a user task request; S2: based on the task unloading total delay model and the mobile device-side total energy consumption model, with a goal of minimizing a task unloading total delay and a mobile device-side total energy consumption, establishing a joint optimization model configured for task unloading and caching and having a constraint; S3: transforming the joint optimization model into a fitness function for a particle, where the user task request is the particle; and S4: determining an optimal solution of the particle by using a particle swarm algorithm based on the fitness function, where the optimal solution of the particle is an optimal task unloading decision of the user task request.

Abstract: The embodiment of the present disclosure provides a data transmission method, a central control terminal, a mobile terminal and a data transmission system and relates to the field of data transmission for realizing data transmission in a multi-person conference in a network-free environment and improving the convenience of data transmission. The data transmission method is applied to a central control terminal and includes: reading an identification information of a mobile terminal in response to a near field communication signal from the mobile terminal; and determining whether the identification information belongs to a target identification set; performing Bluetooth connection and data transmission with the mobile terminal when the identification information belongs to the target identification set.

Abstract: The present application provides an unmanned aerial vehicle (UAV) for a long duration flight. An exemplary UAV may include a UAV body assembly. The UAV may also include a flight control system (FCS) coupled to the UAV body assembly. The UAV may further include a motor coupled to the UAV body assembly at one end and coupled to a propeller at the other end. The FCS is communicatively connected to the motor. A center of gravity (CG) of the UAV is at a point between 21% and 25% of a mean aerodynamic chord (MAC) of the UAV.

Abstract: Disclosed herein is a composition comprising a lipid nanoparticle and a double-stranded oligodeoxynucleotide (dsODN) encapsulated in the lipid nanoparticle. According to the embodiments of the present disclosure, the dsODN comprises two strands complementary to each other, in which the first strand comprises the nucleotide sequence of SEQ ID NO: 1. Also disclosed herein are methods of treating cancers by using the present composition.

Abstract: Disclosed are a borate MWDC with a low dielectric constant and a preparation method thereof by cold sintering. The method for preparing a borate MWDC with a low dielectric constant by cold sintering, including: subjecting a boron source and a metal source to first mixing to obtain a first mixture; subjecting the first mixture to presintering to obtain a presintered material; subjecting the presintered material and a boron oxide solution to second mixing to obtain a second mixture; and subjecting the second mixture to cold sintering to obtain the borate MWDC with the low dielectric constant.

Abstract: A voice control method and apparatus, a readable storage medium, and an electronic device, relating to the technical field of voice control. The method comprises: acquiring user voice information, and creating a voice control relationship between a user and a target voice control window on the basis of the user voice information, wherein the target voice control window is one of a plurality of voice control windows displayed in a display terminal; and converting the user voice information into a control instruction, and executing control content corresponding to the control instruction in the target voice control window.

Abstract: The present disclosure provides an audio adjusting method, device and apparatus, and a storage medium.

Abstract: The present disclosure provides a light-emitting method and a light-emitting device facing a limited condition. The limited condition may include that a light emitted by a light source transmits through a non-display surface of a light-transmitting plate that satisfies a light-transmitting condition so that a display surface of the light-transmitting plate displays a display light that satisfies a display condition. The light-transmitting condition may include a chromaticity coordinate range corresponding to the light-transmitting plate. The display condition may include a chromaticity coordinate range of the display light. The light-emitting method may include the light source satisfying that a chromaticity coordinate range corresponding to the light source is a chromaticity coordinate range of the light source for displaying the display light, and a light color adjustment range corresponding to the light source is a spectrum adjustment range of the light source for displaying the display light.

Abstract: The present invention provides a supporting hook structure, comprising a sleeve, a fixing rod, a first limit unit, a hook and a fixing device. The fixing rod is connected to the side surface of the sleeve. The hook body is connected to one end of the sleeve. The first limit unit is arranged on the side surface of the sleeve and adjacent to the hook body. The first limit unit makes the hook body rotates with the axis direction of the sleeve as a rotation axis. The fixing device is connected to the other end of the sleeve to fix the rotating position of the hook body. Through the above, the hook part enters the proximal thigh from a surgical entrance and the hook part rotates to make the hook part abut against the proximal femur to complete the positioning and fixation of the femur hook structure to the femur.

Abstract: A generating apparatus for generating electrical power from a water flow to electrical energy includes a support structure; an electrical power generation arrangement; and a drain tank. The support structure includes a pipe extending into seawater, a tidal stream generation device in the pipe, and a water tank in fluid communication with the pipe. The tidal stream generation device includes a turbine for directing seawater from the pipe therein, a shaft co-rotated with the turbine, a reduction gearbox connected to the shaft, an output shaft extending out of the reduction gearbox, an alternator driven by the output shaft to convert mechanical energy to electrical energy, and an electrical grid electrically connected to the alternator. The electrical power generation arrangement includes at least one electrical energy generation device in communication with the water tank. Each electrical energy generation device includes interconnected bends and tidal stream generators in the bends.

Abstract: A femoral lift apparatus includes a lift device and a hook device. The hook device is coupled to the lift device. The femoral lift apparatus is labor-saving and can avoid the problem that the conventional femoral lift apparatus may block the surgical view, hinder the operation position for a hip joint replacement surgery. With the assistance of this current femoral lift apparatus, the hip joint replacement surgery can be performed more smoothly.

Abstract: A generating apparatus for generating electrical power from a water flow to electrical energy includes a pump; pipes; tidal stream generation devices; and drains. The pump is connected to and in fluid communication with the pipes. The pump may pump seawater to the pipes and sweater may further flow to the tidal stream generation devices so that the tidal stream generation devices may generate electrical power from a seawater flow to electrical energy. The tidal stream generation device includes a turbine driven by seawater, a shaft co-rotated with the turbine, a reduction gearbox operatively connected to the shaft, an output shaft extending out of the reduction gearbox, and an alternator driven by the output shaft to convert mechanical energy to electrical energy in the form of AC, and an electrical grid electrically connected to the alternator. The drain is connected to the pipe for flowing seawater to the sea.

Abstract: The present invention provides a smart interactive board, a display method therefor, and a readable storage medium.