Abstract: Provided herein are bifunctional compounds that bind a target protein (e.g., a selected protein) and/or induce ubiquitination for degradation of the target protein. In particular, provided are compounds that bind a bromodomain or bromodomain-containing protein (e.g., BET proteins) or histone methyltransferases (HMTs, e.g., enhancer of zeste homolog 1 (EZH1), or FKBP12) and can promote its degradation by recruiting it to the ubiquitin receptor RPN13 (e.g., RA190), for proteasomal degradation. Also provided are pharmaceutical compositions comprising the bifunctional compounds, methods of treating and/or preventing diseases (e.g., proliferative diseases, cancers, benign neoplasms, pathological angiogenesis, inflammatory diseases, and autoimmune diseases) and musculoskeletal diseases, and methods of inducing the degradation of a target (e.g., a target protein) by recruiting it to the ubiquitin receptor RPN13 of the proteasome in a subject by administering a compound or composition described herein.

Abstract: The present disclosure discloses a word vector retrofitting method. The method includes obtaining, by a computing device, a first model and a second model that are generated when original word vectors are trained, the first model being configured to predict a context according to an inputted word, and the second model being configured to predict a target word according to a context; inputting a corpus unit from a target corpus into the first model, inputting an output of the first model into the second model, and determining losses generated by the first model and the second model when the second model outputs the corpus unit; and retrofitting the first model and the second model according to the losses.

Abstract: The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to benzimidazole containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with dysregulation of histone deacetylase (HDAC).

Abstract: According to one embodiment, a monitor apparatus includes a memory and processing circuitry. The processing circuitry acquires first information indicating a position and a moving direction of a target, acquires second information indicating a position of each of moving objects and sensors which are provided in the moving objects, selects at least one of a first moving object for monitoring the target from among the moving objects or a first sensor for monitoring the target from among the sensors, based on the first information and the second information, and transmits third information indicating the target and at least one of the first moving object or the first sensor.

Abstract: Provided are an organic rare-earth solid micelle, a preparation method therefor, and a method for increasing the photoelectric conversion efficiency of a solar battery. A small organic conjugated ligand is taken as a first ligand, an amphiphilic diblock polymer is taken as a second ligand, and the first ligand and the second ligand are mixed and doped with a rare-earth chloride solution, and self-assembled to form an organic rare-earth solid micelle, whereby the fluorescence emission intensity and the fluorescence efficiency of the rare-earth element are improved. Next, the prepared organic rare-earth solid micelle is spin coated on an ITO layer of a solar battery, to prepare a solar battery with the organic rare-earth solid micelle. Therefore the sunlight absorption of a cell is increased, and the photoelectric conversion efficiency is improved. The preparation process is simple, low in cost, high in photoelectric conversion efficiency, and environmentally friendly.

Abstract: A BM23 peptide is obtained by mutating and modifying BMP-2. The BM23 peptide improves stability and duration of in-vivo efficacy relative to BMP-2, has an activity of promoting the differentiation of bone marrow mesenchymal stem cells into chondrocytes and promoting the proliferation of chondrocytes and can be used for repairing cartilage and/or treating osteoarthritis.

Abstract: A BM23 peptide is obtained by mutating and modifying BMP-2. The BM23 peptide improves stability and duration of in-vivo efficacy relative to BMP-2, has an activity of promoting the differentiation of bone marrow mesenchymal stem cells into chondrocytes and promoting the proliferation of chondrocytes and can be used for repairing cartilage and/or treating osteoarthritis.

Abstract: According to one embodiment, a recognition device includes a hardware processor. The hardware processor is configured to identify presence or absence of composition elements of a target from input observation data, acquire setting information indicative of a relationship between a type and composition elements, and identify a type of the target based on the setting information acquired and the presence or absence of the composition elements.

Abstract: The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to benzimidazole containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with dysregulation of histone deacetylase (HDAC).

Abstract: A host device includes a first serial peripheral interface (SPI) and a second SPI to communicate with an embedded multimedia card (eMMC) device. The host device has a mode controller that controls the first SPI to toggle between first transmission and first reception modes for command transmission and response reception, respectively. The mode controller controls the second SPI to toggle between second transmission and second reception modes for data transmission and data reception, respectively.

Abstract: A host device includes a first serial peripheral interface (SPI) and a second SPI to communicate with an embedded multimedia card (eMMC) device. The host device has a mode controller that controls the first SPI to toggle between first transmission and first reception modes for command transmission and response reception, respectively. The mode controller controls the second SPI to toggle between second transmission and second reception modes for data transmission and data reception, respectively.

Abstract: The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to benzimidazole containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with dysregulation of histone deacetylase (HDAC).

Abstract: Provided are an organic rare-earth solid micelle, a preparation method therefor, and a method for increasing the photoelectric conversion efficiency of a solar battery. A small organic conjugated ligand is taken as a first ligand, an amphiphilic diblock polymer is taken as a second ligand, and the first ligand and the second ligand are mixed and doped with a rare-earth chloride solution, and self-assembled to form an organic rare-earth solid micelle, whereby the fluorescence emission intensity and the fluorescence efficiency of the rare-earth element are improved. Next, the prepared organic rare-earth solid micelle is spin coated on an ITO layer of a solar battery, to prepare a solar battery with the organic rare-earth solid micelle. Therefore the sunlight absorption of a cell is increased, and the photoelectric conversion efficiency is improved. The preparation process is simple, low in cost, high in photoelectric conversion efficiency, and environmentally friendly.

Abstract: A high-voltage combined electrical apparatus includes a transformer, at least one circuit breaker, at least one oil/gas separation module and at least one operating mechanism. In an embodiment, the circuit breaker includes a ceramic insulator, an upper outgoing line seat, a lower outgoing line seat, and a disconnecting mechanism connected there between. The oil/gas separation module includes a first end electrically connected to a transformer coil of the transformer, and a second end electrically connected to the lower outgoing line seat. The operating mechanism is connected to and controls the disconnecting mechanism. The high-voltage combined electrical apparatus of an embodiment integrates a circuit breaker and a transformer, omitting the conventional transformer oil/gas sleeve and overhead line, so that the structure thereof is simpler, the cost is lower, the area of ground occupied by the equipment is reduced, and the occurrence of short circuits associated with overhead lines is avoided.

Abstract: A wind power converter device is provided. The wind power converter device includes grid side converters, generator side converters and a DC bus module. Each of the grid side converters includes grid side outputs electrically coupled to a grid and a first and a second DC inputs. Each two of the neighboring grid side converters are connected in series at the second and the first DC inputs. Each of the generator side converters includes generator side inputs electrically coupled to a generator device and a first and a second DC outputs. Each two of the neighboring generator side converters are coupled in series at the second and the first DC outputs. The DC bus module is electrically coupled between the grid side converters and the generator side converters.

Abstract: There is method for detecting the presence or absence of a target analyte in a sample comprising the steps of: allowing an inorganic fluorescent particle to conjugate with a detection biomolecule that is bound to said target analyte, if present in said sample, said target analyte additionally being bound by a capture biomolecule immobilized on or within a nanostructure; and detecting the fluorescence emitted by said inorganic fluorescent particle, said nanostructure being capable of generating a surface plasmon resonance effect when excited by a light source to substantially increase the fluorescence emitted by said inorganic fluorescent particle, wherein the detected fluorescence indicates the presence of said target analyte in said sample.

Abstract: A wind power converter device is provided. The wind power converter device includes grid side converters, generator side converters and a DC bus module. Each of the grid side converters includes grid side outputs electrically coupled to a grid and a first and a second DC inputs. Each two of the neighboring grid side converters are connected in series at the second and the first DC inputs. Each of the generator side converters includes generator side inputs electrically coupled to a generator device and a first and a second DC outputs. Each two of the neighboring generator side converters are coupled in series at the second and the first DC outputs. The DC bus module is electrically coupled between the grid side converters and the generator side converters.

Abstract: The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to benzimidazole containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with dysregulation of histone deacetylase (HDAC).

Abstract: According to one embodiment, a monitor apparatus includes a memory and processing circuitry. The processing circuitry acquires first information indicating a position and a moving direction of a target, acquires second information indicating a position of each of moving objects and sensors which are provided in the moving objects, selects at least one of a first moving object for monitoring the target from among the moving objects or a first sensor for monitoring the target from among the sensors, based on the first information and the second information, and transmits third information indicating the target and at least one of the first moving object or the first sensor.

Abstract: A wind power converter device is provided. The wind power converter device includes grid side converters, generator side converters and a DC bus module. Each of the grid side converters includes grid side outputs electrically coupled to a grid and a first and a second DC inputs. Each two of the neighboring grid side converters are connected in series at the second and the first DC inputs. Each of the generator side converters includes generator side inputs electrically coupled to a generator device and a first and a second DC outputs. Each two of the neighboring generator side converters are coupled in series at the second and the first DC outputs. The DC bus module is electrically coupled between the grid side converters and the generator side converters.