Abstract: A method for natural language instantiation of a planning problem includes receiving, by a computer, a natural language representation of a user's schedule, the user's schedule including a plurality of activities, associating a plurality of biomedical parameters of the user with execution of the plurality of activities to determine an effect of each activity on the plurality of biomedical parameters, based on the association of the plurality of biomedical parameters with the execution of the plurality of activities and a predefined evaluation criteria, calculating a quality score for the user's schedule, optimizing the user's schedule by performing a local search, based on a generic ontology, automatically constructing an ontology including information associated with the plurality of activities and the plurality of biomedical parameters of the user, and based on the constructed ontology, processing the natural language representation of the user's schedule.