Abstract: The present invention belongs to the field of protein engineering, and relates to a hybrid peptide formed by a chymotrypsin inhibitory peptide and an insulin or an analog thereof. The hybrid insulin analogue can resist the degradation of the chymotrypsin to improve the stability, such that the curative effect of direct injection administration can be improved, and moreover, the insulin analogue can penetrate through small intestine epithelium to be directly absorbed and enter blood circulation, thereby achieving oral administration of insulin hybrid peptidedrugs. The present invention further provides a method for preparing a hybrid peptide comprising the chymotrypsin inhibiting peptide and insulin or an analog thereof.

Abstract: Implementations of a jig may include at least one pocket that may include an opening through a thickness of the jig; and a plurality of chamfered corner openings where each of the plurality of chamfered corner openings is located at a corner of the at least one pocket arranged around the opening. The pocket may include angled sides of the opening. The at least one pocket may be formed in a body portion of the jig.

Abstract: Computing devices may implement instant video communication connections for video communications. Connection information for mobile computing devices may be maintained. A request to initiate an instant video communication may be received, and if authorized, the connection information for the particular recipient mobile computing device may be accessed. Video communication data may then be sent to the recipient mobile computing device according to the connection information so that the video communication data may be displayed at the recipient device as it is received. New connection information for different mobile computing devices may be added, or updates to existing connection information may also be performed. Connection information for some mobile computing devices may be removed.

Abstract: A display device and a display method for a menu bar thereof are provided. A display device includes a display screen and a control circuit. The display screen is configured to display content. The control circuit includes a processor and a memory. The memory is configured to store a program executable by the processor. The processor is configured to read the program in the memory and perform the following steps: in response to a touch instruction generated by at least one user, determining, according to the touch position of the touch instruction, a display position of a first menu bar corresponding to the touch instruction, the display position changing with the movement of the touch position; and displaying the first menu bar corresponding to the touch instruction at the display position.

Abstract: The present disclosure provides a sorting scheduling method, apparatus and matrix sorting system in the field of warehousing and logistics technology, wherein the matrix sorting system includes multiple branch lines and multiple ring sorters, each branch line spans multiple ring sorters, each ring sorter is spanned by multiple branch lines, each branch line is provided with multiple sorting stations at each ring sorter, each said branch line is used to convey a stock box to the corresponding sorting station, and the sorted goods to be packaged at said sorting station flow on the corresponding ring sorter. The present disclosure adopts the matrix sorting form, and the order quantity completed by a sorting station can be increased dozens of times compared to the existing sorting station layout, which alleviates the problem of conveyor line blockage and realizes large-scale sorting operations.

Abstract: The present disclosure relates to molecules capable of binding to FGFR3 and methods of use thereof.

Abstract: An application of riluzole, a non-hormone compound, in a treatment of oligospermia provides a useful help for solving the problem of male sterility, and has potential application prospects in the field of medicine.

Abstract: Translucency of a yttria-stabilized zirconia ceramic is improved to achieve even higher translucency than what is currently offered on the market, without greatly altering its mechanical properties. The enhancement is done by incorporating magnesium-containing dopants into the microstructure of yttria-stabilized zirconia ceramic dental ceramics.

Abstract: Disclosed is a method and device for predicting inlet NOx concentration of a denitrification system in a thermal power plant considering measurement delay.

Abstract: A thunder and lightning intercepting apparatus. In the present application, a sufficiently long target upward leader can be generated, so as to construct a thunder and lightning discharge channel; and several lightning rods are used to receive overhead lightning strikes and side lightning strikes that are from different directions, so as to intercept the overhead lightning strikes and side lightning strikes, thereby effectively attenuating lightning strike currents and reducing the intensity of a lightning-strike electromagnetic field. Therefore, the present application may be applicable to buildings that need protection against direct lightning strikes and induction lightning strikes, and is particularly applicable for use in systems such as onshore/offshore wind power, high-voltage power transmission, or high-speed rail overhead lines, thus playing a role in effectively intercepting lightning strikes from different directions.

Abstract: Provided in the embodiments of the present disclosure is an image processing method. The method comprises: acquiring real-time video images; selecting a target area from an image frame, at a selected moment, of the real-time video images; and inputting a first image of the target area into an image processing model to obtain a target image, wherein the resolution of the target image is higher than that of the first image; and providing a first interface, and displaying the target image on the first interface.

Abstract: A display substrate and a manufacturing method thereof, a display apparatus, and a method for reducing driving voltage of a display substrate. The display substrate comprises a red sub-pixel, further comprises: a first electrode layer (10), a second electrode layer (50), a plurality of light emitting units disposed between the first electrode layer (10) and the second electrode layer (50) and connected in series, and a charge generation layer disposed between two adjacent light emitting units. A microcavity is formed between the first electrode layer (10) and the second electrode layer (50). The light emitting units comprise a first hole transport layer (21), a second hole transport layer (22) and an emitting layer. The emitting layer comprises a red light emitting layer located at the red sub-pixel. At least one of the light emitting units further comprises a red light emitting auxiliary layer located at the red sub-pixel.

Abstract: Methods for making natural-looking dental prosthesis that meet several aesthetic indicators are described, including precoloring methods, compositions, and kits for obtaining a natural-looking dental prosthesis. In one aspect, several different compositions are applied to certain surface areas of a dental prosthesis via a precolor pattern. Exemplary compositions include a colorant composition, an opaque composition, and an incisal composition. The colorant composition may include Zn, Al and at least one coloring agent. The opaque composition may include at least one opaquing agent. The incisal composition may include a Mg component.

Abstract: Multispecific binding molecules (MBMs) comprising an N-terminal scFv, a first Fab and a second Fab, MBM conjugates comprising the MBMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the MBMs and MBM conjugates, methods of using the MBMs, MBM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the MBMs, cells engineered to express the MBMs, and methods of producing MBMs.

Abstract: A data processing method, apparatus and device are provided. The data processing method includes: obtaining application requirement information according to function requirement information and preset template information; performing resource exploration according to the application requirement information; when a result of the resource exploration indicates that a target application is allowed to operate, according to the application requirement information, allocating, from target operation platform resource, application resource to the target application, and creating an operation environment for the target application; deploying and releasing the target application according to the application resource and the operation environment; wherein the target application is an application program corresponding to the application requirement information.

Abstract: The invention provides a flame-retardant and windproof wadding, which is obtained by using a polymer containing an imide ring as a base material and interlacing and compounding it with at least one polyester fiber in a spinning stage; and a preparation method and special equipment thereof. The characteristics and advantages of the present invention are as follows: the flame-retardant and windproof wadding provided by the present invention uses polyimide fiber as the base material and various fibers; through the adjustment of the preparation method and special equipment, the improvement of the windproof, thermal insulation and flame-retardant effect of the wadding is finally realized; and the same time, various fibers in the wadding are highly mixed, forming a homogeneous, moderately cross-linked and fluffy mixed structure, which can greatly reduce the probability of falling off of the layered structure in the traditional process.

Abstract: The present invention relates to the technical field of molecular biology, and in particular, to an anti-CD40 nanobody, and a preparation method therefor and use thereof. The anti-CD40 nanobody provided by the present invention has three unique complementarity determining regions, namely CDR1, CDR2, and CDR3. The present invention further provides a sequence encoding the nanobody or its VHH chain, a corresponding expression vector, and a host cell capable of expressing the nanobody. The present invention includes immunizing an alpaca by constructing a CD40 antigen to obtain a PBMC of the alpaca and constructing a vector; screening an anti-CD40 antibody through phage display; and finally obtaining a highly sensitive and specifically binding antibody through functional assays and sequencing result analysis. The nanobody provided by the present invention can specifically recognize and bind to CD40.