Abstract: The invention discloses compounds for treatment or prevention of liver diseases. The compounds are compounds represented by a formula (I) or (II), optical isomers or pharmaceutically acceptable salts of the compounds. The compounds and optical isomers or pharmaceutically acceptable salts of the compounds can be applied to preparation of drugs for treatment or prevention of liver diseases.

Abstract: A water-soluble polymer having an aliphatic polycarbonate backbone, a first carbonate monomer with at least one hydrophilic functionality, and a second carbonate monomer with at least one hydrophobic functionality is able to completely and quickly eliminate a virus from a human and/or animal cell. The at least one hydrophilic functionality is a sulfate, a sulfonate, a carboxylate, and/or a phosphate and the at least one hydrophobic functionality is an alkyl. The hydrophilic/hydrophobic functionalities of the polymer may be tuned to enhance the antiviral properties of the polymer and/or to decrease any cytotoxicity associated with the application of the polymer to a human and/or animal cell. The antiviral polymer is biocompatible and biodegradable.

Abstract: A method of calibrating a motor assembly includes selecting an electric motor and a motor controller for the motor assembly, obtaining at least one electric motor parameter of the electric motor, calculating a correction factor for the electric motor based upon the at least one electric motor parameter, and programming the motor controller with the correction factor.

Abstract: Techniques regarding chemical compounds with antimicrobial functionality are provided. For example, one or more embodiments describe herein can comprise a monomer that can comprise a molecular backbone. The molecular backbone can comprise a bis(urea)guanidinium structure covalently bonded to a functional group, which can comprise a radical. Also, the monomer can have supramolecular assembly functionality.

Abstract: The present disclosure discloses a display device. The display device includes a first display structure, a second display structure and a backlight device. The first display structure includes first pixels arranged in an array, the first pixels are divided into multiple dimming areas, and each dimming area includes at least one first pixel. The first display structure is for adjusting the transmittance of each dimming area for lights emitted by the backlight device according to an image to be displayed in the next frame of the second display structure.

Abstract: The present invention relates to pyrrolo-aromatic heterocyclic compounds, a preparation method therefor and medical use thereof. Particularly, the present invention relates to a compound represented by formula I, a preparation method therefor, a pharmaceutical composition comprising the compound, and use of the compound as a BTK kinase inhibitor. The compound and the pharmaceutical composition comprising same can be used for the treating diseases associated with BTK kinase activity, such as inflammations, autoimmune disorders, and cancers. The definition of each substituent in formula I is the same as that in the description.

Abstract: The present invention belongs to the field of medicinal chemistry. Specifically disclosed is a class of URAT1 inhibitors for promoting uric acid excretion, which are compounds as represented by the structure of formula (I) or pharmaceutically acceptable salts thereof. Experiments show that the compounds provided by the present invention have a very good inhibitory effect on the transport of uric acid by hURAT1 in HEK293 transfected cells, and that such compounds have a good application prospect in the treatment of hyperuricemia or gout.

Abstract: Disclosed are an indoor non-contact human activity recognition method and system. The method comprises: collecting an indoor reflected signal by using an antenna array; filtering the reflected signal to obtain a noise-removed reflection signal; and inputting the noise-removed reflected signal to a pre-trained human activity recognition model, and determining a human activity category, the human activity recognition model being a pre-trained CNN network model based on a transfer learning algorithm. The recognition method and system have the advantages that: the antenna array is configured for collecting human actions to carry out activity recognition indoors, which can be applied to home-based care scenes; original data is denoised, so that most of high-frequency noises can be removed, and a phase change of the signal is reserved; a CNN structure is adopted for training so as to reduce a complexity of the system location-free sensing.

Abstract: The present disclosure provides a method for treating depression using a therapeutically effective amount of a pharmaceutical agent. The pharmaceutical agent can inhibit an activity of an astroglial potassium channel, and especially inhibit the functionality of Kir4.1, in astrocytes in the lateral habenula of a subject so that the abnormal burst firings of neurons in the lateral habenula of the subject can be suppressed. The pharmaceutical agent can include a vector expressing a target nucleotide sequence in the astrocytes in the lateral habenula, whose expression is configured to suppress Kir4.1 expression by RNA interference, or to block Kir4.1 functionality by a dominant negative effect of a mutant Kir4.1 protein. The pharmaceutical agent can alternatively comprise a small molecule compound, or an active macromolecule such as an anti-Kir4.1 antibody, that can directly inhibit the astroglial potassium channel activity.

Abstract: A piece picking system includes at least one main conveyor unit and a plurality of sorting modules. The at least one main conveyor unit and the plurality of sorting modules are arranged crosswise in a matrix, and the at least one main conveyor unit is located above or below the plurality of sorting modules. A plurality of picking stations are arranged at a side of each main conveyor unit, and are adjacent to each of the sorting modules. The main conveyor unit is configured to convey a first container carrying an item to be picked. The picking station is configured to pick the item in a required quantity from the first container conveyed by the main conveyor unit according to an order requirement. The sorting module is configured to sort the item picked by the adjacent picking station. The system aggregates the sorting capabilities of the plurality of sorting modules.

Abstract: Antibacterial coatings and methods of making the antibacterial coatings are described herein. A first branched polyethylenimine (BPEI) layer is formed and a first glyoxal layer is formed on a surface of the BPEI layer. The first BPEI layer and the first glyoxal layer are cured to form a crosslinked BPEI coating. The first BPEI layer can be modified with superhydrophobic moieties, superhydrophilic moieties, or negatively charged moieties to increase the antifouling characteristics of the coating. The first BPEI layer can be modified with contact-killing bactericidal moieties to increase the bactericidal characteristics of the coating.

Abstract: Techniques regarding post polymerization modifications to polycarbonate polymers via a flow reactor are provided. For example, one or more embodiments described herein can comprise a cyclic carbonate monomer that can be employed to facilitate polymerization of one or more polycarbonate platforms susceptible to post polymerization modification. For instance, one or more embodiments can regard a cyclic carbonate molecular backbone covalently bonded to an aryl halide functional group via in accordance with a chemical structure selected from the group consisting of: In the chemical structures, “R1” can be selected from the group consisting of a hydrogen atom and a functional group comprising a first alkyl group; “L” can represent a linkage group, comprising: a second alkyl group and an end group having at least one member selected from the group consisting of an oxygen atom and a nitrogen atom; and “A” can represent the aryl halide functional group.

Abstract: Antibacterial coatings and methods of making the antibacterial coatings are described herein. A first branched polyethylenimine (BPEI) layer is formed and a first glyoxal layer is formed on a surface of the BPEI layer. The first BPEI layer and the first glyoxal layer are cured to form a crosslinked BPEI coating. The first BPEI layer can be modified with superhydrophobic moieties, superhydrophilic moieties, or negatively charged moieties to increase the antifouling characteristics of the coating. The first BPEI layer can be modified with contact-killing bactericidal moieties to increase the bactericidal characteristics of the coating.

Abstract: A method for formation of a vaccine comprising combining a cationic polymer adjuvant with an antigen to form first immunoparticles through charge interactions and producing a treatment formulation for the vaccine comprising the first immunoparticles.

Abstract: A driving method, a driving circuit and a touch-display apparatus are provided. The driving method includes providing a gate driving signal to a gate line, providing a pixel voltage to a data line, and providing a common electrode driving signal to a common electrode, wherein a pixel display operation is performed based on the gate driving signal, the pixel voltage, and the common electrode driving signal, and simultaneously, a touch detection operation is performed based on the common electrode driving signal. The driving method realizes the effect of simultaneously performing a pixel display operation and a touch detection operation, and solves the problem that the pixel display operation of the touch-display apparatus is affected in the touch detection stage.

Abstract: Disclosed are an image dehazing method and system based on CycleGAN. The method comprises: acquiring a to-be-processed hazy image; and inputting the image into a pre-trained densely connected CycleGAN, and outputting a clear image. The densely connected CycleGAN comprises a generator, the generator comprises an encoder, a converter and a decoder, the encoder comprises a densely connected layer for extracting features of an input image, the converter comprises a transition layer for combining the features extracted at the encoder stage, the decoder comprises a densely connected layer and a scaled convolutional neural network layer, the densely connected layer is used for restoring original features of the image, and the scaled convolutional neural network layer is used for removing a checkerboard effect of the restored original features to obtain a finally output clear image.

Abstract: A clip-on fan includes a specialized clamping clip that is attached to rectangular or cylindrical tent poles that are commonly used for grow tents; wherein fans are essential components for growing in tents and the current designs clip-on fans do not meet the needs of indoor growers; the clip-on fan comprising a fan assemblage and clip clasp assemblage arranged at the base of the complete product, wherein the clip is able to grasp to the vertical tubular structure of a grow tent; the grasping clasp assembly consisting of: a left clip plate, a right clip plate, a clip plate rotation shaft, a clip spring, a fan connection hole and, a clip clamp opening; the left and right clip plates are connected in a bilateral symmetry through the clip plate rotation shaft at the central connection position.

Abstract: Techniques regarding killing of a pathogen with one or more ionene compositions having antimicrobial functionality are provided. For example, one or more embodiments can comprise a method, which can comprise contacting a Mycobacterium tuberculosis microbe with a chemical compound. The chemical compound can comprise an ionene unit. Also, the ionene unit can comprise a cation distributed along a molecular backbone. The ionene unit can have antimicrobial functionality. The method can further comprise electrostatically disrupting a membrane of the Mycobacterium tuberculosis microbe in response to the contacting.

Abstract: The subject matter of this invention relates to hydrogel compositions and, more particularly, to hydrogel compositions comprising block copolymers (BCPs) capable of self-assembly into nanoparticles for the delivery and controlled release of therapeutic cargos.