Abstract: The present invention discloses a distributed electrical cross apparatus, and a system and method for the distributed electrical cross apparatus implementing an SNC cascade protection. The apparatus includes a backboard and at least four single-boards integrated with electrical cross units, wherein the single-boards are inserted in the limited number of slots in the backboard, and these single-boards also set line-side service access units, client-side service access units and backboard access units. The present invention has both accessing of line-side services and accessing of client-side services in the same single-board, access and flexible scheduling of various services such as line-side services and client-side services and so on are implemented on the backboard with limited number of slots, and the function of the distributed electrical cross system processing various services is increased in the case of low cost.

Abstract: A method and system for service clock transparent transmission in an optical transport network (OTN) are provided. The system includes a service accessing end and an OTN receiving end; the method includes the following steps: the OTN receiving end performs de-mapping operation to an OTN frame after receiving the OTN frame, and performs two-level buffering operation to the service data flow recovered therefrom, a first buffering unit performs a homogenization treatment to the service data flow and then outputs to a second buffering unit, which the second buffering unit outputs the service data flow according to the service clock after receiving the service data flow. After adopting the present invention, it is able to ensure that the quality of the recovered service clock is relatively higher, which meets the customer requirement on the related specification of the service clock.

Abstract: The present invention discloses a method for realizing cross-connect of optical channel data units (ODUk), which comprises: mapping the accessed services to the ODUk, and mapping the services mapped to the ODUk to the ODUk time slot frames according to the requirements of the time slot frames; mapping the ODUk time slot frames to the intermediate frame structures; performing the cross-connect for ODUk services in the intermediate frame structures. The present invention also discloses an apparatus for realizing cross-connect of ODUk. The present invention directly supports cross-connect of ODUk, so as to realize simple scheduling for the Optical Transport Network (OTN) services, and improve the resource utilization factor and the integration level.

Abstract: A method and system for service clock transparent transmission in an optical transport network (OTN) are provided. The system includes a service accessing end and an OTN receiving end; the method includes the following steps: the OTN receiving end performs de-mapping operation to an OTN frame after receiving the OTN frame, and performs two-level buffering operation to the service data flow recovered therefrom, a first buffering unit performs a homogenization treatment to the service data flow and then outputs to a second buffering unit, which the second buffering unit outputs the service data flow according to the service clock after receiving the service data flow. After adopting the present invention, it is able to ensure that the quality of the recovered service clock is relatively higher, which meets the customer requirement on the related specification of the service clock.

Abstract: The present invention discloses a distributed electrical cross apparatus, and a system and method for the distributed electrical cross apparatus implementing an SNC cascade protection. The apparatus includes a backboard and at least four single-boards integrated with electrical cross units, wherein the single-boards are inserted in the limited number of slots in the backboard, and these single-boards also set line-side service access units, client-side service access units and backboard access units. The present invention has both accessing of line-side services and accessing of client-side services in the same single-board, access and flexible scheduling of various services such as line-side services and client-side services and so on are implemented on the backboard with limited number of slots, and the function of the distributed electrical cross system processing various services is increased in the case of low cost.

Abstract: The present invention discloses an device for cross protection, including: a service unit source end, configured to map optical data unit (ODUk) signals into the same time slots of n line similar optical transport network (OTN) frame format (OTUxG) data buses, and obtain m+n line OTUxG data through protective coding and then send to a combination cross unit; the combination cross unit, configured to split and recombine the m+n line OTUxG data in the time slot, and then send to a service unit destination end; the service unit destination end, configured to protectively decode the m+n line OTUxG data, recover n line OTUxG data, and extract corresponding ODUk signals from the same time slots of n line OTUxG data.

Abstract: The present invention discloses a method for realizing cross-connect of optical channel data units (ODUk), which comprises: mapping the accessed services to the ODUk, and mapping the services mapped to the ODUk to the ODUk time slot frames according to the requirements of the time slot frames; mapping the ODUk time slot frames to the intermediate frame structures; performing the cross-connect for ODUk services in the intermediate frame structures. The present invention also discloses an apparatus for realizing cross-connect of ODUk. The present invention directly supports cross-connect of ODUk, so as to realize simple scheduling for the Optical Transport Network (OTN) services, and improve the resource utilization factor and the integration level.

Abstract: A macromolecule includes a polymer directly tethered or bonded to a polyatomic functionality. The polyatomic functionality can be located at a terminus of the polymer and can be generated concurrent with or soon after formation of the polymer. The macro-molecule can be prepared from a functionalized polymer by hydrolyzing and condensing (e.g., by a sol-gel process) functionalities in which one or more alkoxy groups are bound to a silica atom in the presence of an excess of a compound that includes a Si, Ti, Zr, Sn, Al, or Fe atom. Such macromolecules can be used in the manufacture of vulcanizates and tire components, either alone or blended with other polymers and/or other particulate fillers.

Abstract: The present invention relates to compounds and methods useful for the detection and treatment of disorders associated with frameshift mutations in coding microsatellite regions. The compounds and methods are applicable in cancers, especially of DNA mismatch repair deficient (MMR) sporadic tumors and HNPCC associated tumors. The compounds disclosed in the invention are useful for detection of disorders and in therapy such as e.g. immuno-therapy. The diagnostic methods relate to diagnosis and prognostic assessment of disorders associated with frameshift polypeptides originating from frameshift mutations in coding microsatellite regions of genes based on the detection of immunological entities directed against said frameshift polypeptides in body fluids.

Abstract: It has been discovered that any RNA can be targeted for cleavage by RNase P from prokaryotic or eukaryotic cells using a suitably designed oligonucleotide ("external guide sequence", or EGS) to form a hybrid with the target RNA, thereby creating a substrate for cleavage by RNase P in vitro. The EGS hydrogen bonds to the targeted RNA to form a partial tRNA like structure including the aminoacyl acceptor stem, the T stem and loop, and part of the D stem. An EGS can be modified both by changes in sequence and by chemical modifications to the nucleotides. The EGS can be a separate molecule or can be combined with an RNase P catalytic RNA sequence to form a single oligonucleotide molecule ("RNase P internal guide sequence" or RIGS). Methods are also disclosed to randomly select and to express a suitable EGS or RIGS in vivo to make a selected RNA a target for cleavage by a host cell RNase P or introduced RIGS, thus preventing expression of the function of the target RNA.

Abstract: It has been discovered that any RNA can be targeted for cleavage by RNAase P from eukaryotic cells, for example, human RNAase P, using a suitably designed oligoribonucleotide ("external guide sequence", or EGS) to form a hybrid with the target RNA, thereby creating a substrate for cleavage by RNAase P in vitro. The EGS hydrogen bonds to the targeted RNA to form a partial tRNA like structure including the aminoacyl acceptor stem, the T stem and loop, and part of the D stem. The most efficient EGS with human RNAase P is the EGS in which the anticodon stem and loop was deleted. Modifications can also be made within the T-loop. Methods are also disclosed to randomly select and to express a suitable EGS in vivo to make a selected RNA a target for cleavage by the host cell RNAase P, thus preventing expression of the function of the target RNA. The methods and compositions should be useful to prevent the expression of disease-causing genes in vivo.

Abstract: It has been discovered that any RNA can be targeted for cleavage by RNAase P from eukaryotic cells, for example, human RNAase P, using a suitably designed oligoribonucleotide ("external guide sequence", or EGS) to form a hybrid with the target RNA, thereby creating a substrate for cleavage by RNAase P in vitro. The EGS hydrogen bonds to the targeted RNA to form a partial tRNA like structure including the aminoacyl acceptor stem, the T stem and loop, and part of the D stem. The most efficient EGS with human RNAase P is the EGS in which the anticodon stem and loop was deleted. Modifications can also be made within the T-loop. Methods are also disclosed to randomly select and to express a suitable EGS in vivo to make a selected RNA a target for cleavage by the host cell RNAase P, thus preventing expression of the function of the target RNA. The methods and compositions should be useful to prevent the expression of disease-causing genes in vivo.