Abstract: The disclosure provides a hybrid membrane camouflaged nanomedicine loaded with oxidative phosphorylation inhibitor and preparation method thereof. The nanomedicine comprises an inner core and an outer shell coated on the periphery of the inner core. The inner core is a ROS-responsive drug-loaded nanoparticle, and the drug loaded by the ROS-responsive nanocarrier is an oxidative phosphorylation inhibitor. The outer shell is a hybrid membrane of mitochondrial membrane and cancer cell membrane. The nanomedicines can cross the BBB and reach tumor sites by the homologous targeting of cancer cell membrane, and then they can homologously target and enter mitochondria by the mitochondrial membrane. Subsequently, under the high-level ROS environment of the mitochondria, the ROS responsive drug-loaded nanoparticle releases the oxidative phosphorylation inhibitor due to the swell and degradation of the inner core, so that the safe and efficient targeted GBM therapy is achieved.

Abstract: A circuit includes a microcontroller having a clock output and a data output. The microcontroller includes a serial-peripheral interface (SPI) circuit, a pulse-width modulation (PWM) generator, and a central processing unit (CPU). The SPI circuit is configured to provide an SPI clock signal and an SPI data signal to the data output. The PWM generator is configured to provide a continuous PWM signal to the clock output. The CPU is coupled to the SPI circuit and the PWM generator, and the CPU has executable instructions configured to synchronize the PWM signal to the SPI clock signal.

Abstract: The present disclosure provides a detection method for low-quality fake face images based on domain-invariant feature learning, including the following steps: S1, inputting datasets into a residual network (ResNet)-50, and forward propagating low-quality compressed input images and original images corresponding thereto; S2, obtaining high-frequency information of two datasets of different resolutions; and using the high-frequency information to compensate for features discarded in the compression process; and S3, performing T-distributed stochastic neighbor embedding (T-SNE) operation on outputs from the ResNet-50 at a final stage to obtain feature distributions of a high-quality dataset and a low-quality dataset. Domain invariance is used for inscribing correct artificial artifact traces, alleviating the overfitting on low-quality compressed images.

Abstract: A circuit includes a microcontroller having a clock output and a data output. The microcontroller includes a serial-peripheral interface (SPI) circuit, a pulse-width modulation (PWM) generator, and a central processing unit (CPU). The SPI circuit is configured to provide an SPI clock signal and an SPI data signal to the data output. The PWM generator is configured to provide a continuous PWM signal to the clock output. The CPU is coupled to the SPI circuit and the PWM generator, and the CPU has executable instructions configured to synchronize the PWM signal to the SPI clock signal.

Abstract: A circuit includes a microcontroller having a clock output and a data output. The microcontroller includes a serial-peripheral interface (SPI) circuit, a pulse-width modulation (PWM) generator, and a central processing unit (CPU). The SPI circuit is configured to provide an SPI clock signal and an SPI data signal to the data output. The PWM generator is configured to provide a continuous PWM signal to the clock output. The CPU is coupled to the SPI circuit and the PWM generator, and the CPU has executable instructions configured to synchronize the PWM signal to the SPI clock signal.

Abstract: The present disclosure provides a gene editing nanocapsule and a preparation method and use thereof. The gene editing nanocapsule has a core-shell structure, wherein the inner core includes a Cas/sgRNA ribonucleoprotein complex, and the outer shell includes a polymer, the Cas/sgRNA ribonucleoprotein complex has a gene editing function, and the polymer acts as a carrier for the Cas/sgRNA ribonucleoprotein complex and protects it, because the polymer contains tumor microenvironment sensitive molecules, the nanocapsules can be efficiently released in tumor cells. Further, the surface of the outer shell can be modified with a targeting agent, so that the nanocapsule can specifically target tumor cells, which improves the endocytosis efficiency of the nanocapsule. The gene editing nanocapsule has good biocompatibility and biosafety, and is expected to become a safe and efficient gene therapy drug for tumors.

Abstract: A photodiode chip, a photodiode, and a method for controlling a wavelength of a photodiode are provided. The photodiode chip sequentially incudes, above a substrate, a grating layer and a ridge waveguide layer. The ridge waveguide layer includes multiple ridge waveguides. Each of the multiple ridge waveguides corresponds to one column of gratings in the multiple columns of gratings below. The grating layer includes multiple columns of gratings. At least two columns of gratings have different grating period pitches.

Abstract: A display module and a display device are provided. The display module includes a display panel, a flexible circuit board, and a printed circuit board. The display panel includes a bonding area. The flexible circuit board and the printed circuit board are electrically bonded and connected to the display panel in the bonding area, and are connected by a connector. The connector includes a first connection board and a second connection board. A side of the first connection board includes a groove including first pins. A side of the second connection board facing the first connection board includes second pins. The first pins and the second pins have a one-to-one correspondence. The second pins are plugged into the grooves, and are in contact with and electrically connected to the first pins; and a portion of at least one of the first pins is coated with a first insulating layer.

Abstract: Provided are a photoelectric chip, a manufacturing method and an installation method, which relate to the field of optical communication and transmission technologies. The chip is provided with a light-splitting groove (3), and the light-splitting groove (3) runs through an absorption layer (2) of the chip; the back of the chip is a light-entering side; the light-splitting groove (3) is configured to transmit and split out part (151) of incident light (15), and the other part (152) of the incident light (15) enters the absorption layer (2) for photovoltaic conversion. The photoelectric chip can split light and monitor optical power of the incident light.

Abstract: A quantum well structure, a method for processing a chip, and a chip are provided. The quantum well structure includes an indium aluminum arsenide (InAlAs) quantum well layer and an indium aluminum gallium arsenide (InAlGaAs) quantum well layer. The InAlAs quantum well layer is implemented as multiple InAlAs quantum well layers. The thickness of the InAlGaAs quantum well layer is the same as the thickness of the InAlAs quantum well layer. The InAlGaAs quantum well layer is disposed between two adjacent InAlAs quantum well layers. The thickness of the InAlAs quantum well layer ranges from 0.4 nm to 0.6 nm. The number of the multiple InAlAs quantum well layers ranges from 3 to 17.

Abstract: The present disclosure provides an siRNA nanocapsule and a preparation method and use thereof, relating to the technical field of biomedical engineering. The siRNA nanocapsule provided in the present disclosure includes siRNA and a shell encapsulating the siRNA and polymerized by a monomer A and a monomer B. The monomer A has a double bond at one end, and is electrostatically bound with the siRNA, and the monomer B includes molecules for improving tumor microenvironment sensitivity. The siRNA nanocapsule provided in the present disclosure is suitable for a wide range of clinical applications.

Abstract: Provided are a photodetector, a manufacturing method thereof, and a lidar system. A photosensitive region of the photodetector is circular and has a diameter range of 100-300 ?m. Compared with a conventional photodetector having a photosensitive region with a diameter of 50 ?m, the photodetector of the present invention can have a detection range greater than 200 m, responsivity greater than 20 A/W and a dark current less than 10 nA.

Abstract: A barcoded transposase complex and an application thereof in high-throughput sequencing. Provided is a transposase recognition element, having the following structure: X(m)Y(f)N(n), in which X(m) represents a transposase recognition region of a double-stranded nucleic acid structure, Y(f) represents a spacer region of a single-stranded DNA structure, and N(n) represents a sample barcode of a single-stranded DNA structure. The high-molecular-weight DNA is processed using the barcoded transposase complex, to obtain a lot of barcoded DNA fragments. The barcoded DNA fragments obtained from each high-molecular-weight DNA are mixed to obtain a mixing sample. A carrier having a molecular barcode is adopted to capture. An exonuclease is adopted for processing, and then transposase is released. StLFR technology is adopted to construct a DNA library. The barcoded transposase complex can be applied to hybrid sequencing of a high-throughput sequencing platform.

Abstract: The present disclosure relates to the field of ecological restoration of a coal gangue hill, and in particular, to a solid waste-based porous material, a method for preparing the solid waste-based porous material, and a method of ecological restoration of the coal gangue hill by applying the solid waste-based porous material. A coal-based solid waste restoration material and mycorrhizal solid bacterial agent are mixed to restore the coal gangue hill, the coal-based solid waste restoration material is prepared by mixing coal-based solid waste porous materials, low-rank coal, and waste organic matter and adding a microbial quickly decomposition agent for aerobic fermentation and standing.

Abstract: The disclosure provides a hybrid membrane camouflaged nanomedicine loaded with oxidative phosphorylation inhibitor and preparation method thereof. The nanomedicine comprises an inner core and an outer shell coated on the periphery of the inner core. The inner core is a ROS-responsive drug-loaded nanoparticle, and the drug loaded by the ROS-responsive nanocarrier is an oxidative phosphorylation inhibitor. The outer shell is a hybrid membrane of mitochondrial membrane and cancer cell membrane. The nanomedicines can cross the BBB and reach tumor sites by the homologous targeting of cancer cell membrane, and then they can homologously target and enter mitochondria by the mitochondrial membrane. Subsequently, under the high-level ROS environment of the mitochondria, the ROS responsive drug-loaded nanoparticle releases the oxidative phosphorylation inhibitor due to the swell and degradation of the inner core, so that the safe and efficient targeted GBM therapy is achieved.

Abstract: The present disclosure provides a gene editing nanocapsule and a preparation method and use thereof. The gene editing nanocapsule has a core-shell structure, wherein the inner core includes a Cas/sgRNA ribonucleoprotein complex, and the outer shell includes a polymer, the Cas/sgRNA ribonucleoprotein complex has a gene editing function, and the polymer acts as a carrier for the Cas/sgRNA ribonucleoprotein complex and protects it, because the polymer contains tumor microenvironment sensitive molecules, the nanocapsules can be efficiently released in tumor cells. Further, the surface of the outer shell can be modified with a targeting agent, so that the nanocapsule can specifically target tumor cells, which improves the endocytosis efficiency of the nanocapsule. The gene editing nanocapsule has good biocompatibility and biosafety, and is expected to become a safe and efficient gene therapy drug for tumors.

Abstract: The present disclosure relates to the field of ecological restoration of a coal gangue hill, and in particular, to a solid waste-based porous material, a method for preparing the solid waste-based porous material, and a method of ecological restoration of the coal gangue hill by applying the solid waste-based porous material. A coal-based solid waste restoration material and mycorrhizal solid bacterial agent are mixed to restore the coal gangue hill, the coal-based solid waste restoration material is prepared by mixing coal-based solid waste porous materials, low-rank coal, and waste organic matter and adding a microbial quickly decomposition agent for aerobic fermentation and standing.

Abstract: Provided are a photodetector, a manufacturing method thereof, and a lidar system. A photosensitive region of the photodetector is circular and has a diameter range of 100-300 ?m. Compared with a conventional photodetector having a photosensitive region with a diameter of 50 ?m, the photodetector of the present invention can have a detection range greater than 200 m, responsivity greater than 20 A/W and a dark current less than 10 nA.

Abstract: The present disclosure provides an siRNA nanocapsule and a preparation method and use thereof, relating to the technical field of biomedical engineering. The siRNA nanocapsule provided in the present disclosure includes siRNA and a shell encapsulating the siRNA and polymerized by a monomer A and a monomer B. The monomer A has a double bond at one end, and is electrostatically bound with the siRNA, and the monomer B includes molecules for improving tumor microenvironment sensitivity. The siRNA nanocapsule provided in the present disclosure is suitable for a wide range of clinical applications.