Patents by Inventor Yana Cen

Yana Cen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2-fluorinated riboses and arabinoses and methods of use and synthesis
    Patent number: 9790252
    Abstract: Disclosed are halogenated 2-deoxy-lactone, 2?-deoxy-nucleosides, and derivatives thereof, for example, a compound of formula (I). Also disclosed are a composition comprising a pharmaceutically acceptable carrier and at least one compound or salt of the invention, and a method of treating a disorder is selected from the group consisting of an abnormal cellular proliferation, a viral infection, and an autoimmune disorder.
    Type: Grant
    Filed: July 1, 2010
    Date of Patent: October 17, 2017
    Assignee: CORNELL UNIVERSITY
    Inventors: Anthony A. Sauve, Yana Cen
  • Activation and activators of SIRT5
    Patent number: 9603862
    Abstract: The invention provides a method of increasing a deacetylase activity of SIRT5 by contacting SIRT5 with an agent that binds SIRT5 and reduces the Km of SIRT5 for a substrate, thereby increasing the deacetylase activity of SIRT5. The invention also provides a method for treating a urea cycle disorder in a mammal, as well as a method of assaying a sirtuin modulator.
    Type: Grant
    Filed: December 14, 2010
    Date of Patent: March 28, 2017
    Assignee: CORNELL UNIVERSITY
    Inventors: Anthony Sauve, Yana Cen
  • Reagents and methods for sirtuin capture
    Patent number: 9290791
    Abstract: The invention provides a method of preparing a sirtuin complex, a method for detecting a sirtuin in a sample, and a method of screening for compounds which inhibit the deacetylase activity of a sirtuin. The method includes (a) providing a sirtuin substrate having the formula: (b) providing NAD+ or an NAD+ analog having the formula: and (c) providing a sirtuin, wherein R1-R4, A1, A2, and n are as defined herein.
    Type: Grant
    Filed: May 18, 2011
    Date of Patent: March 22, 2016
    Assignee: CORNELL UNIVERSITY
    Inventors: Anthony A. Sauve, Yana Cen
  • REAGENTS AND METHODS FOR SIRTUIN CAPTURE
    Publication number: 20130065248
    Abstract: The invention provides a method of preparing a sirtuin complex. The invention also provides a method of detecting a sirtuin in a sample comprising use of the aforesaid sirtuin complex.
    Type: Application
    Filed: May 18, 2011
    Publication date: March 14, 2013
    Applicant: CORNELL UNIVERSITY
    Inventors: Anthony A. SAUVE, Yana CEN
  • ACTIVATION AND ACTIVATORS OF SIRT5
    Publication number: 20120329748
    Abstract: The invention provides a method of increasing a deacetylase activity of SIRT5 by contacting SIRT5 with an agent that binds SIRT5 and reduces the Km of SIRT5 for a substrate, thereby increasing the deacetylase activity of SIRT5. The invention also provides a method for treating a urea cycle disorder in a mammal, as well as a method of assaying a sirtuin modulator.
    Type: Application
    Filed: December 14, 2010
    Publication date: December 27, 2012
    Applicant: CORNELL UNIVERSITY
    Inventors: Anthony Sauve, Yana Cen
  • 2-FLUORINATED RIBOSES AND ARABINOSES AND METHODS OF USE AND SYNTHESIS
    Publication number: 20120108535
    Abstract: Disclosed are halogenated 2-deoxy-lactone, 2?-deoxy-nucleosides, and derivatives thereof, for example, a compound of formula (I). Also disclosed are a composition comprising a pharmaceutically acceptable carrier and at least one compound or salt of the invention, and a method of treating a disorder is selected from the group consisting of an abnormal cellular proliferation, a viral infection, and an autoimmune disorder.
    Type: Application
    Filed: July 1, 2010
    Publication date: May 3, 2012
    Applicant: CORNELL UNIVERSITY
    Inventors: Anthony A. Sauve, Yana Cen