Abstract: A flexible substrate has at least one bendable region. The flexible substrate includes a flexible base, a first electrode layer disposed on the base, a first insulating layer disposed on a side of the first electrode layer away from the base, and a second electrode layer disposed on a side of the first insulating layer away from the base. The first electrode layer includes at least one first detection electrode, and the second electrode layer includes at least one second detection electrode. An orthogonal projection of a first detection electrode on the base overlaps at least partially with an orthogonal projection of a second detection electrode on the base. A region where orthogonal projections of the first detection electrode and the second detection electrode on the base are located overlaps with a bendable region.

Abstract: A fitness device includes two support frames mounted in a box, two driving motors mounted on the two support frames, a pull rope reel connected to the driving motors, a fitness pull rope wound around the pull rope reel and extending out of the box, and a control system for controlling the driving motors. The control system includes a main controller, a power module, a communication module connected to the main controller, a driving circuit and a sampling module electrically connected to the driving motors and the main controller. The power module is electrically connected to the main controller and the communication module. The driving circuit is electrically connected to the power module, the main controller and the driving motors. The two symmetrical driving motors are used to drive the pull rope reel to drive the fitness pull rope, such that shakes and vibrations generated during exercise can be offset.

Abstract: A direct drive motor includes a base, a stator assembly provided on the outer periphery of the base, a rotating shaft assembly provided in the base, and a rotor assembly connected to the rotating shaft assembly and covering the stator assembly. The base includes an inner end, an outer end, and a receiving chamber passing through the inner end and the outer end. The rotating shaft assembly is rotatably mounted in the receiving chamber. A first circuit board is mounted at the inner end; a recess is formed in the outer end; a second circuit board is mounted in the recess; and the first circuit board is connected to the second circuit board. When being applied to an apparatus such as an intelligent device and an intelligent robot, the direct drive motor is good in stability, high in intelligence, reliable in overall structure, and strong in practicability.

Abstract: Disclosed are an adjustable load pressure compensation balancing system, an end cover, and a counterbalance valve. The adjustable load pressure compensation balancing system comprises: an adjustable orifice control module and a counterbalance valve control module, wherein the adjustable orifice control module is used for receiving control oil generated when a luffing system descends and oil from a descending cavity of a luffing cylinder; the counterbalance valve control module is used for receiving the control oil generated when the luffing system descends; the pressure applied to the counterbalance valve control module by the control oil is maximum when the luffing system starts to descend, and then decreases gradually; and the pressure applied to the adjustable orifice control module by the oil from the descending cavity is minimum when the luffing system starts to descend, and then increases gradually.

Abstract: A salt of a nitrogen-containing fused heterocyclic compound or a crystal form thereof, and a preparation method therefor, a pharmaceutical composition thereof, and a use thereof, in particular, a salt of compound I as shown below or a crystal form thereof, and a preparation method, a pharmaceutical composition and a use. The salt of compound I or the crystal form thereof exhibits at least one of the following advantages: improved bioavailability, great mechanical properties, improved chemical stability, excellent fluidity, great compressibility, and improved dissolution characteristics.

Abstract: The present invention relates to the field of biomedicine, particularly to double-stranded RNA molecules targeting CKIP-1 and uses thereof, particularly to use of the double-stranded RNA molecules for the treatment of inflammatory diseases such as arthritis, particularly rheumatoid arthritis.

Abstract: The present application relates to a pregabalin sustained release composition, comprising: (a) an active ingredient; (b) a matrix-forming agent; (c) a swelling agent; (d) a gelling agent; and optionally a filler. The pregabalin sustained release composition provided in the present application can rapidly swell in volume when exposed to aqueous medium until exceeding the dimeter of human gastric pyloric (13 mm). It thereby prolongs the gastric emptying time to increase the retention time of pregabalin in the stomach and enhances absorption of pregabalin in the small intestine and ascending colon. Moreover, the pregabalin sustained release composition provided herein achieves a sustained release for 24 h, which allows QD (once a day) administration, reduces administration number, and improves patient compliance.

Abstract: The present invention provides a supported metal catalyst with synergistic sites, a preparation method therefor and an application thereof. The preparation method of this catalyst is to utilize the unsaturated cubane-like structure, M cation with catalytic activity is introduced into the cluster core unit. By using the vertex vacancy as the capturing center, and adjusting the impregnation temperature to maximize the loading of the cluster precursor, as well as depending on the electrostatic adsorption of the support and the confinement of the cluster structural unit, the number of S vacancies and the distance between S vacancies and Miso sites are effectively controlled through liquid phase reduction and atmosphere treatment at room temperature to obtain supported X3MSx/Al2O3 catalyst with Miso-Vs synergistic sites.

Abstract: A method for preparing a rubber for an elastomer of a flexible joint, includes: weighing hydrogenated nitrile raw rubber, a silica reinforcing agent, aramid fiber pulp, carbon black, liquid nitrile rubber, zinc oxide, stearic acid, an antioxidant, and a peroxide crosslinking agent; plasticating the hydrogenated nitrile raw rubber in a first internal mixer at 125-135° C., collecting a resulting product and cooling, to yield a plasticized rubber; preheating the liquid nitrile rubber; adding the plasticized rubber to a second internal mixer, further adding the aramid fiber pulp, the zinc oxide, the stearic acid, and the antioxidant to the second internal mixer for first mixing; adding the carbon black to the second internal mixer for second mixing; adding the silica reinforcing agent and the preheated liquid nitrile rubber to the second internal mixer for third mixing; and collecting a discharged product when a temperature of the second internal mixer is 140° C.

Abstract: A P2X3 and/or P2X2/3 receptor antagonist of formula (I), a pharmaceutical composition comprising the same, and a use thereof in preparing a drug for preventing or treating a disease mediated by the P2X3 and/or P2X2/3 receptor antagonist.

Abstract: The present invention discloses a receptor inhibitor of formula (I), a composition comprising the same and the usage thereof.

Abstract: The present invention discloses a hollow spherical catalyst for a fixed bed with internal fluidization of particles and a method for preparing the same. The preparation method used in the present invention is characterized in: fully mixing precious metal nanopowder with an organic oil phase to form an internal oil phase; preparing a gel ball of an oil-in-water structure by taking an aluminum oxide molding solution as an outer aqueous phase using an independently researched and developed coaxial dual-dropper forming apparatus; and then preparing a hollow aluminum oxide catalyst containing precious metal powder from the gel ball through processes of aging, calcination, and reduction. The resulting catalyst is expressed as X@Al2O3, where the precious metal nanopowder X is wrapped inside hollow Al2O3, and the catalyst has an outer diameter of 1.5-5.0 mm, a shell pore diameter (aluminum oxide) of 10-50 nm, and the precious metal nanopowder sized 200-500 nm.

Abstract: The prevent disclosure provides a method and apparatus for adjusting a perspective of a direction indicator, an electronic device, and a storage medium, which includes that: a first area and a second area corresponding to a first direction indicator are acquired, where the first direction indicator is configured to indicate a forward direction in a panorama display scene, the first area is a visible area of the first direction indicator in a graphical user interface, and the second area is an invisible area of the first direction indicator outside the graphical user interface; an initial perspective range corresponding to the second area is acquired; a target perspective range to which a first perspective belongs is determined from the initial perspective range, and a second direction indicator corresponding to the target perspective range is displayed; and the first perspective is adjusted to a second perspective based on the second direction indicator.

Abstract: Provided are compounds represented by general formula (I), which can be used for treating ATR kinase-mediated diseases, such as proliferative diseases, such as cancer. Further provided are a pharmaceutical composition of the compound represented by general formula (I), a use thereof in treating ATR kinase-mediated diseases, and a preparation thereof.

Abstract: Cuy/MMgOx interfacial catalyst for selective alkyne hydrogenation and its preparation method are disclosed. The preparation method of the catalyst includes: the mixture of salt and alkali solution is nucleated momentarily by nucleation/crystallization isolation method, preparing the composite metal hydroxide CuyMMg4-LDHs as precursor, which has typical hexagonal morphology of the double hydroxide; the precursor is topologically transformed by heat treatment to produce unsaturated oxide; the catalyst with Cuy-MMgOx interface structure is prepared by separating and electronically modifying Cu particles. By adjusting the ratio of Cu2+/M3+ in LDHs, the electronic and geometric structure of Cuy-MMgOx interface can be flexibly controlled, thus enhancing the reaction activity, product selectivity and stability. The catalyst can be used in the selective hydrogenation of various alkynes in the fields of petrochemical and fine chemical industry, with the outstanding catalytic activity and C?C double bond selectivity.

Abstract: The present invention discloses a catalyst for in-situ CO2 capture and coupling reduction with biomass oxidation, a preparation method therefor and an application thereof. The catalyst is applied to the coupling reaction of photocatalytic CO2 reduction and biomass oxidation. The preparation of the catalyst is to synthesize layered double hydroxides (LDHs) containing CO32? between layers by using coprecipitation method, hydrothermal method, sol-gel method and the like, wherein the chemical formula is [M1-x2+Mx3+(OH)2]x+(An?)x/n·mH2O, which has a thickness of 20-30 nm and an average particle diameter of 60-90 nm. Then metal ion vacancy defects are produced on LDHs laminate by using a NaOH/KOH selective etching to obtain the corresponding catalyst.

Abstract: The present invention relates to a Rho-associated protein kinase inhibitor of formula (I), a pharmaceutical composition comprising the same, a preparation method thereof, and a use of the same in preventing or treating a disease mediated by Rho-associated protein kinase (ROCK).

Abstract: A catalyst for pyrolysis of 1,2-dichloroethane (1,2-DCE) to prepare vinyl chloride monomer (VCM), a preparation method, a use, and a regeneration method thereof are provided. The catalyst for pyrolysis of 1,2-DCE to prepare VCM includes a silicon-aluminum molecular sieve. The catalyst for pyrolysis of 1,2-DCE to prepare VCM has high reaction activity and excellent selectivity and solves the problem that the pyrolysis of 1,2-DCE to prepare VCM in the prior art involves high reaction temperature and large energy consumption and is prone to coking and carbon deposition.

Abstract: An osmium-containing conjugated polymer and methods thereof. A structural formula of the osmium-containing conjugated polymer is formula I, a reaction formula of the osmium-containing conjugated polymer is a formula II.

Abstract: A P2X3 and/or P2X2/3 receptor antagonist of formula (I), a pharmaceutical composition comprising the same, and a use thereof in preparing a drug for preventing or treating a disease mediated by the P2X3 and/or P2X2/3 receptor antagonist.