Abstract: The present application provides an underwater-wellhead feeding tool assembly and a use method thereof. The device controls a controller to add pressure to an inside of a drive cylinder through a first pipeline via a first port, and to add pressure to a cavity apace between a pressure-bearing cylinder and the drive cylinder through a first branch line; the controller controls, through a third branch line, the drive device to transmit a torque to the underwater wellhead feeding tool, and transmit, through a second branch line, an axial force to the underwater wellhead feeding tool; and then a sensing component transmits a detected stress signal and/or strain signal to a data acquisition device through a test lead, thereby testing and analyzing an effect of different force field conditions on mechanical behaviors and performance of the underwater wellhead feeding tool.

Abstract: The present disclosure provides a device and a method for controllable forging of a forming flow line of a complex-shaped component. The device includes a frame, a shaping unit, a cushioning unit, and a cleaning unit, and the frame is used to mount and fix the shaping unit, the cushioning unit, and the cleaning unit; the shaping unit is used to improve a shaping capacity of processed parts; the cushioning unit is used to reduce a vibration in a metal shaping process to avoid an impact on the shaping of the metal; the cleaning unit is used to clean up a surface of a mold after shaping; when the metal is put into the mold, the metal is extruded and shaped through the shaping unit, and at the same time, the cushioning unit is used to offset the vibration generated by the shaping unit during the shaping process.

Abstract: A SNP molecular marker combination for identifying an AA broiler includes 25 SNP molecular markers, SNP sites of the SNP molecular markers 1 to 25 are located at a 51st position of each of nucleotide sequences shown in SEQ ID NO: 1 to 25. The SNP molecular marker combination for identifying the AA broiler in the disclosure has apparent species specificity of the AA broiler, is a unique mutation and importance determining site for the AA broiler, and can quickly identify authenticity of the AA broiler with less genotype information, providing new technical references for the identification, conservation, and genetic breeding of chicken breeds in the future.

Abstract: The present disclosure provides a two-stroke pumping method and oil production device, and relates to the technical field of oil production. The oil production device comprises a pump body, wherein the oil production device further comprises a central tube of a hollow structure, and the central tube is partially located in the pump body and coaxially arranged with the pump body; a traveling valve and a standing valve are arranged on the left side and the right side of the outer wall of the central tube respectively, and the traveling valve is arranged between the pump body and the central tube; the standing valve is located outside the pump body; the traveling valve and the standing valve are matched with the pump body and the central tube to form an oil pumping space; and an oil pumping assembly is further arranged in the oil pumping space.

Abstract: The present application provides an underwater-wellhead feeding tool assembly and a use method thereof. The device controls a controller to add pressure to an inside of a drive cylinder through a first pipeline via a first port, and to add pressure to a cavity apace between a pressure-bearing cylinder and the drive cylinder through a first branch line; the controller controls, through a third branch line, the drive device to transmit a torque to the underwater wellhead feeding tool, and transmit, through a second branch line, an axial force to the underwater wellhead feeding tool; and then a sensing component transmits a detected stress signal and/or strain signal to a data acquisition device through a test lead, thereby testing and analyzing an effect of different force field conditions on mechanical behaviors and performance of the underwater wellhead feeding tool.

Abstract: Provided are a drive method of a display panel, a storage medium, a drive device and a display device. The drive method includes: in an Nth frame, applying a first voltage to the second electrode and a first data signal matched with a first voltage to the first electrode through the pixel drive circuit based on grayscale data of the Nth frame; wherein N is a positive integer; in an (N+1)th frame applying a second voltage to the second electrode and a second data signal matched with the second voltage to the first electrode through the pixel drive circuit based on grayscale data of the (N+1)th frame, wherein the first voltage is different from the second voltage.

Abstract: A display substrate, a display device, and a method for driving a display device are provided. The display substrate includes a substrate, a drive circuit layer formed on the substrate, a light-emitting unit on a side of the drive circuit layer away from the substrate, and a light-transmitting layer on a side of the light-emitting unit away from the substrate; the light-emitting unit comprises a first electrode layer, a light-emitting layer and a second electrode layer which are laminated in sequence, the second electrode layer comprises a plurality of second electrode patterns which are arranged independently and insulated from each other, and at least part of the second electrode patterns are connected to different common voltage terminals. According to the embodiments of the present disclosure, the proportion of light of different colors in the light-emitting units located at different positions is controlled, which helps to improve the display effect.

Abstract: A system is provided for generating a microfluidic channel. The system may include a co-flow generator having a delivery tube configured to provide a support liquid. The co-flow generator may include a coupling having an outlet configured to provide an epoxy resin. The delivery tube may be centrally positioned in the outlet of the coupling such that the delivery tube and the outlet together eject a co-flow of epoxy and support liquid into a tubular shell. The system may further include a conductive ring defining a hole through which the tubular shell extends. Heating the conductive ring causes or hastens curing of the epoxy resin to form a micro-channel defined by the cured epoxy around the support liquid.

Abstract: A detection circuit, a driving circuit, and a display panel and a driving method therefor are provided. The detection circuit includes an acquisition circuit and a processing circuit. The acquisition circuit includes a test transistor and an energy storage element, where, for the test transistor, a control end is configured to be coupled to the data signal terminal, a first end is configured to be written with a detection signal, and a second end is coupled to the energy storage element; and a structural characteristic of the test transistor is identical to a structural characteristic of the driving transistor. The processing circuit is coupled to the second end of the test transistor, and configured to detect a voltage at the second end of the test transistor as a detection voltage and regulate the data signal according to the detection voltage.

Abstract: Provided is a chimeric antigen receptor, comprising an antigen binding region, a transmembrane domain and an intracellular signaling region. The antigen binding region comprises an antibody specifically targeting CD7, and the intracellular signaling region consists of a co-stimulatory domain, a primary signal transduction domain, and a ?C chain or intracellular region thereof. Also provided are an engineered immune cell comprising the chimeric antigen receptor and a pharmaceutical composition thereof, and use of the engineered immune cell/pharmaceutical composition for treating cancers.

Abstract: Provided are an ROR1-targeting antibody, and a multispecific antibody, a chimeric antigen receptor, an antibody conjugate, a pharmaceutical composition and a kit which comprise same, and the use thereof in the diagnosis/treatment/prevention of diseases associated with ROR1 expression.

Abstract: An engineered immune cell, which expresses (i) a cell surface molecule that specifically recognizes a ligand, (ii) an exogenous interleukin, and (iii) an exogenous Flt3L, XCL2, and/or XCL1; the engineered immune cell can be used for treating cancer, infection, or autoimmune diseases; and compared with a traditional engineered immune cell, the engineered immune cell has significantly improved tumor killing activity.

Abstract: Provided are an NKG2A-targeting antibody, and a multispecific antibody, a chimeric receptor, an antibody conjugate, a pharmaceutical composition and a kit which comprise same, and the use thereof in the diagnosis/treatment/prevention of diseases associated with NKG2A expression.

Abstract: The present invention discloses a method for building a co-culture model for Caco-2/RAW-264.7 cells induced by lipopolysaccharides and an application of the co-culture model. The method includes: 1) culturing Caco-2 cells and RAW-264.7 cells; 2) inoculating the 5 Caco-2 cells onto an AP side of an upper chamber of a Transwell plate, and incubating; 3) inoculating the RAW-264.7 cells onto a 24-well plate, and incubating; 4) transferring the upper chamber of the Transwell plate into the 24-well plate; 5) dissolving lipopolysaccharides in PBS to prepare a stock solution, filtering, and diluting for later use; and 6) adding an LPS-10% DMEM medium on a BL side, incubating, and forming an intestinal inflammation model.

Abstract: The present invention provides a CD19-targeting humanized antibody, and a multispecific antibody, chimeric receptor, antibody conjugate, pharmaceutical composition, and kit comprising the CD19-targeting humanized antibody, and a use thereof in the diagnosis/treatment/prevention of diseases associated with CD19 expression.

Abstract: Provided in the present invention are a BCMA-targeting single-domain antibody and an encoding nucleotide sequence thereof. Also provided in the present invention are a multispecific antibody, a chimeric antigen receptor, and an antibody conjugate containing the BCMA single domain antibody, and a pharmaceutical composition and kit containing said antibodies, chimeric antigen receptor and antibody conjugate, and the use thereof in the diagnosis/treatment/prevention of diseases associated with BCMA expression.

Abstract: Provided is a chimeric antigen receptor, comprising a ligand-binding domain, a transmembrane domain, a co-stimulatory domain, and an intracellular signaling domain. The co-stimulatory domain comprises an intracellular region of an NK-activated receptor or a ligand thereof. Also provided are an engineered immune cell comprising the chimeric antigen receptor and a use thereof in treatment of diseases, such as cancers, autoimmune diseases, and infections.

Abstract: Provided is an engineered immune cell. The engineered immune cell expresses (i) a chimeric receptor, and (ii) exogenous CCL3, CCL4 and/or CCL5, has improved tumor killing activity, and can be used to treat cancer, infection or autoimmune diseases.

Abstract: A downhole displacement impact method and an impact drilling tool are provided, which relates to the field of drilling tools. The downhole displacement impact drilling tool includes a flow passing sleeve, a first main shaft, an impact-bearing seat, and a second main shaft that are all formed by annular structures and are connected in sequence from top to bottom. A vibration sleeve, a vibration starting seat, and an impact head are connected in sequence from top to bottom on the impact-bearing seat. The vibration sleeve is connected and fixed to the impact head through a connecting sleeve. The vibration starting seat synchronously rotates with the impact-bearing seat through a spline connection therebetween. The vibration starting seat generates an up-down periodic displacement along an axial direction of the vibration starting seat during rotating.

Abstract: The present invention provides a CD7-targeting humanized antibody, and a multispecific antibody, chimeric antigen receptor, antibody conjugate, pharmaceutical composition, and kit comprising the CD7-targeting humanized antibody, and a use thereof in the diagnosis/treatment/prevention of diseases associated with CD7 expression.