Patents by Inventor Yanbo Wen

Yanbo Wen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant human replication-deficient adenovirus comprising a modified nucleic acid encoding the Marburg virus envelope glycoprotein
    Patent number: 11453704
    Abstract: The present invention relates to a nucleotide sequence as shown in SEQ ID NO: 1 for encoding a Marburg virus envelope glycoprotein, and to a human replication-deficient recombinant adenovirus capable of expressing the nucleotide sequence and a preparation method therefor, as well as an application thereof in the preparation of a vaccine against Marburg virus disease. The vaccine uses an E1 and E3 deleted replication-deficient human type-5 adenovirus as a vector, and HEK293 cells integrating an adenovirus E1 gene as a packaging cell line, and a protective antigen gene carried is a codon-optimized Marburg virus Angola strain envelope glycoprotein gene. After codon optimization of the envelope glycoprotein gene, significant expression of envelope glycoprotein can be detected in transfected cells.
    Type: Grant
    Filed: August 27, 2018
    Date of Patent: September 27, 2022
    Assignee: Academy of Military Medical Science, PLA
    Inventors: Wei Chen, Shipo Wu, Lihua Hou, Yanbo Wen, Zhe Zhang, Busen Wang, Xiaohong Song, Jinlong Zhang, Ling Fu
  • MARBURG VIRUS VACCINE WITH HUMAN REPLICATION-DEFICIENT ADENOVIRUS AS VECTOR
    Publication number: 20200392188
    Abstract: The present invention relates to a nucleotide sequence as shown in SEQ ID NO: 1 for encoding a Marburg virus envelope glycoprotein, and to a human replication-deficient recombinant adenovirus capable of expressing the nucleotide sequence and a preparation method therefor, as well as an application thereof in the preparation of a vaccine against Marburg virus disease. The vaccine uses an E1 and E3 deleted replication-deficient human type-5 adenovirus as a vector, and HEK293 cells integrating an adenovirus E1 gene as a packaging cell line, and a protective antigen gene carried is a codon-optimized Marburg virus Angola strain envelope glycoprotein gene. After codon optimization of the envelope glycoprotein gene, significant expression of envelope glycoprotein can be detected in transfected cells.
    Type: Application
    Filed: August 27, 2018
    Publication date: December 17, 2020
    Applicant: Academy of Military Medical Science, PLA
    Inventors: Wei Chen, Shipo Wu, Lihua Hou, Yanbo Wen, Zhe Zhang, Busen Wang, Xiaohong Song, Jinlong Zhang, Ling Fu