Publication number: 20100249126
Abstract: Phosphatidylinositol (PI) 3-kinase inhibitor compounds (I), their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases.
Type:
Application
Filed:
January 22, 2007
Publication date:
September 30, 2010
Applicant:
NOVARTIS VACCINES AND DIAGNOSTICS INC.
Inventors:
Matthew Burger, Zhi-Jie Ni, Sabina Pecchi, Gordana Atallah, Sarah Bartulis, Kelly Frazier, Aaron Smith, Joelle Verhagen, Yanchen Zhang, Allan Wagman, Simon Ng, Keith Pfister, Daniel J. Poon, Alicia Louie, Teresa Pick, Paul Barsanti, Edwin Iwanowicz, Wendy Fantl, Thomas Hendrickson, Mark Knapp, Hanne Meritt, Charles Voliva, Marion Wiesmann, Xiahua Xin
Publication number: 20100075965
Abstract: Phosphatidylinositol (PI) 3 kinase inhibitor compounds, their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, phospholipid kinases, G-protein coupled receptors, and phosphatases.
Type:
Application
Filed:
February 14, 2007
Publication date:
March 25, 2010
Inventors:
Zhi-Jie Ni, Sabina Pecchi, Matthew Burger, Wooseok Han, Aaron Smith, Gordana Atallah, Sarah Bartulis, Kelly Frazier, Joelle Verhagen, Yanchen Zhang, Ed Iwanowicz, Tom Hendrickson, Mark Knapp, Hanne Merritt, Charles Voliva, Marion Wiesmann, Darren Mark Legrand, Ian Bruce, James Dale, Jiong Lan, Barry Levine, Abran Costales, Jui Liu, Teresa Pick, Daniel Menezes
