Abstract: The disclosure provides compositions and methods related to activating alpha-kinase 1 (ALPK1) for modulating an immune response and treating or preventing cancer, infection, inflammation and related diseases and disorders as well as potentiating an immune response to a target antigen. The disclosure also provides heterocyclic compounds of formula (I) as agonists of alpha protein kinase 1 (ALPK1) and their use in activating ALPK1, modulating an immune response and treating diseases such as cancer, wherein A1, A2, L1, L2, L3, Z1, Z2, W1, W2, R1, R2, R3, R4, R5, R6 and R7 are defined herein.

Abstract: The present disclosure relates to a method and a system for determining a cell migration capacity. The method includes performing a scratching operation on cells by a cell scratching device to form at least one scratch and photographing and analyzing the at least one scratch by a cell image analysis device to determine a migration capacity of the cells.

Abstract: A system for acquiring multi-fluorescence images includes an excitation light source configured to irradiate an excitation beam onto a surface of a test sample, so that the test sample emits multi-fluorescence signals. The multi-fluorescence signals include at least two fluorescence signals. The system also includes an optical detection device configured to acquire the multi-fluorescence signals, an optical lens disposed between the optical detection device and the test sample, and a multi-band filter disposed between the optical detection device and the optical lens and/or between the test sample and the optical lens. The optical lens is configured to converge the multi-fluorescence signals emitted by the test sample to the optical detection device. The multi-band filter has at least two transmission intervals corresponding to at least two wavelength intervals of the at least two fluorescence signals.

Abstract: The present disclosure belongs to the field of bioengineering, and relates to breeding of industrial microorganisms, in particular to a genetically engineered strain of Saccharomyces cerevisiae, method for constructing the same, and its use for brewing, the genetically engineered strain of Saccharomyces cerevisiae heterogeneously overexpresses an acetaldehyde dehydrogenase gene ALD6, an acetyl-CoA synthase gene ACS1 and an alcohol acyltransferase gene AeAT9. The Saccharomyces cerevisiae strain with high yield of ethyl acetate and low yield of higher alcohols provided by the present disclosure not only maintains excellent ethanol fermentation characteristics, but also reducing the production of higher alcohols which adversely affect the comfort after drinking, which is of great significance for a well-maintained and strengthened flavor characteristics of Chinese Baijiu, an improved and stabilized quality thereof, and even a reform in the fermentation process thereof.

Abstract: The present disclosure belongs to the field of bioengineering, and relates to breeding of industrial microorganisms, in particular to a genetically engineered strain of Saccharomyces cerevisiae, method for constructing the same, and its use for brewing, the genetically engineered strain of Saccharomyces cerevisiae heterogeneously overexpresses an acetaldehyde dehydrogenase gene ALD6, an acetyl-CoA synthase gene ACS1 and an alcohol acyltransferase gene AeAT9. The Saccharomyces cerevisiae strain with high yield of ethyl acetate and low yield of higher alcohols provided by the present disclosure not only maintains excellent ethanol fermentation characteristics, but also reducing the production of higher alcohols which adversely affect the comfort after drinking, which is of great significance for a well-maintained and strengthened flavor characteristics of Chinese Baijiu, an improved and stabilized quality thereof, and even a reform in the fermentation process thereof.

Abstract: Methods for uploading a file to a television set and playing a file, television set and user equipment are disclosed. The method for uploading a file to a television set includes: sending by a browser in a User Equipment, UE, a request to the television set to obtain a file upload page, wherein the request carries a Uniform Resource Locator, URL, address of the file upload page; and receiving by the browser in the UE the file upload page with which the television set responds, and uploading at least one file through the file upload page to the television set.

Abstract: Methods for uploading a file to a television set and playing a file, television set and user equipment are disclosed. The method for uploading a file to a television set includes: sending by a browser in a User Equipment, UE, a request to the television set to obtain a file upload page, wherein the request carries a Uniform Resource Locator, URL, address of the file upload page; and receiving by the browser in the UE the file upload page with which the television set responds, and uploading at least one file through the file upload page to the television set.

Abstract: Some embodiments of the application provide a window displaying method of a mobile terminal and the mobile terminal. The method may comprise the following steps: determining that a starting mode of an Activity to be started is a window mode; and obtaining first window attribute data corresponding to the Activity to be started to display the Activity to be started according to the first window attribute data.