Patents by Inventor Yanfang Fu

Yanfang Fu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Using Truncated Guide RNAs (tru-gRNAs) to Increase Specificity for RNA-Guided Genome Editing
    Publication number: 20230407341
    Abstract: Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems, using truncated guide RNAs (tru-gRNAs).
    Type: Application
    Filed: March 6, 2023
    Publication date: December 21, 2023
    Inventors: J. Keith Joung, Jeffry D. Sander, Morgan Maeder, Yanfang Fu
  • RECOMBINASE COMPOSITIONS AND METHODS OF USE
    Publication number: 20230131847
    Abstract: Methods and compositions for modulating a target genome are disclosed.
    Type: Application
    Filed: May 20, 2022
    Publication date: April 27, 2023
    Inventors: Jacob Rosenblum RUBENS, Robert James CITORIK, Stephen Hoyt CLEAVER, Cecilia Giovanna Silvia COTTA-RAMUSINO, Yanfang FU
  • Using truncated guide RNAs (tru-gRNAs) to increase specificity for RNA-guided genome editing
    Patent number: 11634731
    Abstract: Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems, using truncated guide RNAs (tru-gRNAs).
    Type: Grant
    Filed: September 16, 2019
    Date of Patent: April 25, 2023
    Assignee: The General Hospital Corporation
    Inventors: J. Keith Joung, Jeffry D. Sander, Morgan Maeder, Yanfang Fu
  • METHODS OF SUBSTITUTING PATHOGENIC AMINO ACIDS USING PROGRAMMABLE BASE EDITOR SYSTEMS
    Publication number: 20220401530
    Abstract: Provided herein are compositions and methods of using base editors comprising a polynucleotide programmable nucleotide binding domain and a nucleobase editing domain in conjunction with a guide polynucleotide. Also provided herein are base editor systems for editing nucleobases of target nucleotide sequences.
    Type: Application
    Filed: May 11, 2019
    Publication date: December 22, 2022
    Applicant: Beam Therapeutics Inc.
    Inventors: David Bryson, John Evans, Michael Packer, Yanfang Fu, Nicole Gaudelli, Jason Michael Gehrke, J. Keith Joung
  • RECOMBINASE COMPOSITIONS AND METHODS OF USE
    Publication number: 20220396813
    Abstract: Methods and compositions for modulating a target genome are disclosed.
    Type: Application
    Filed: January 18, 2022
    Publication date: December 15, 2022
    Inventors: Jacob Feala, Yanfang Fu, Jacob Rosenblum Rubens, Robert James Citorik, Michael Travis Mee, Molly Krisann Gibson
  • METHODS OF SUPPRESSING PATHOGENIC MUTATIONS USING PROGRAMMABLE BASE EDITOR SYSTEMS
    Publication number: 20210371858
    Abstract: Provided herein are compositions and methods of using base editors comprising a polynucleotide programmable nucleotide binding domain and a nucleobase editing domain in conjunction with a guide polynucleotide. Also provided herein are base editor systems for editing nucleobases of target nucleotide sequences.
    Type: Application
    Filed: May 11, 2019
    Publication date: December 2, 2021
    Applicant: Beam Therapeutics Inc.
    Inventors: John Evans, Yanfang Fu, Michael Packer
  • Using Truncated Guide RNAs (tru-gRNAs) to Increase Specificity for RNA-Guided Genome Editing
    Publication number: 20200071730
    Abstract: Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems, using truncated guide RNAs (tru-gRNAs).
    Type: Application
    Filed: September 16, 2019
    Publication date: March 5, 2020
    Inventors: J. Keith Joung, Jeffry D. Sander, Morgan Maeder, Yanfang Fu
  • Using truncated guide RNAs (tru-gRNAs) to increase specificity for RNA-guided genome editing
    Patent number: 10415059
    Abstract: Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems, using truncated guide RNAs (tru-gRNAs).
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: September 17, 2019
    Assignee: The General Hospital Corporation
    Inventors: J. Keith Joung, Jeffry D. Sander, Morgan Maeder, Yanfang Fu
  • Using Truncated Guide RNAs (tru-gRNAs) to Increase Specificity for RNA-Guided Genome Editing
    Publication number: 20170152508
    Abstract: Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems, using truncated guide RNAs (tru-gRNAs).
    Type: Application
    Filed: February 10, 2017
    Publication date: June 1, 2017
    Inventors: J. Keith Joung, Jeffry D. Sander, Morgan Maeder, Yanfang Fu
  • GENETIC CORRECTION OF MYOTONIC DYSTROPHY TYPE 1
    Publication number: 20170088819
    Abstract: The invention relates to polynucleotides suitable for reducing or eliminating the expression of expanded repeat RNA (CUGexp) of the dystrophy myotonic-protein kinase (DMPK) gene in a cell of a DM-1 patient. The polynucleotides are a combination of a polynucleotide for a site specific nuclease targeting the dystrophy myotonic-protein kinase (DMPK) gene locus, and a donor polynucleotide having 5? and 3? regions which are homologous with the sequence of DMPK gene which flank the target site of the nuclease. The invention further relate to in vivo and in vitro methods to reduce or eliminate CTG repeats in the DMPK gene. The invention further relates to the medical use of polynucleotides and cells for treating DM-1 patient.
    Type: Application
    Filed: May 18, 2015
    Publication date: March 30, 2017
    Inventors: Thierry VANDENDRIESSCHE, Marinee CHUAH, J. Keith JOUNG, Yanfang FU, Deepak REYON
  • Using truncated guide RNAs (tru-gRNAs) to increase specificity for RNA-guided genome editing
    Patent number: 9567604
    Abstract: Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems, using truncated guide RNAs (tru-gRNAs).
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: February 14, 2017
    Assignee: The General Hospital Corporation
    Inventors: J. Keith Joung, Jeffry D. Sander, Morgan Maeder, Yanfang Fu
  • Using Truncated Guide RNAs (tru-gRNAs) to Increase Specificity for RNA-Guided Genome Editing
    Publication number: 20140295557
    Abstract: Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems, using truncated guide RNAs (tru-gRNAs).
    Type: Application
    Filed: March 14, 2014
    Publication date: October 2, 2014
    Applicant: The General Hospital Corporation
    Inventors: J. Keith Joung, Jeffry D. Sander, Morgan Maeder, Yanfang Fu