Abstract: The present invention discloses a multi-energy complementary system for a co-associated abandoned mine and a use method. The multi-energy complementary system for a co-associated abandoned mine includes a mining mechanism, a grouting mechanism and an energy mechanism. In the present invention, the mining of coal and uranium resources is realized through the mining mechanism, the subsidence and seepage reduction of the stratum is realized through the grouting mechanism, and the effective utilization of waste resources is realized through the energy mechanism. Finally, with the efficient cooperation of the three mechanisms, safe and efficient development and utilization of co-associated resources in the full life cycle are realized, and the purposes of green and efficient mining of coal and uranium resources and secondary development of a coal seam goaf are achieved, thereby facilitating the realization of dual-carbon goals and the development of low-carbon green energy.

Abstract: The disclosure provides compositions and methods related to activating alpha-kinase 1 (ALPK1) for modulating an immune response and treating or preventing cancer, infection, inflammation and related diseases and disorders as well as potentiating an immune response to a target antigen. The disclosure also provides heterocyclic compounds of formula (I) as agonists of alpha protein kinase 1 (ALPK1) and their use in activating ALPK1, modulating an immune response and treating diseases such as cancer, wherein A1, A2, L1, L2, L3, Z1, Z2, W1, W2, R1, R2, R3, R4, R5, R6 and R7 are defined herein.

Abstract: Provided are compounds of Formula (I) or (II) and related compositions and methods for their use as inhibitors of alpha-kinase 1 (ALPK1).

Abstract: An intelligent experimental device for collaborative mining of associated resources includes a signal transmission mechanism, a pressure maintaining mechanism, a feeding mechanism, and a reaction mechanism. The signal transmission mechanism includes a centralized controller, an annunciator, signal receivers, a power supply, a power cord, signal transmitters, and signal sensing valves. The pressure maintaining mechanism includes ambient and axial pressure oil chambers, ambient and axial pressure pumps, ambient and axial pressure liquid distribution tanks, a comprehensive pressure distribution pipe, and hydraulic transmission pipes. The feeding mechanism includes monitoring analyzers, temperature controllers, solution transfer pipes, seepage pumps, mixture conveying pipes, a comprehensive liquid distributor, an aggregate chamber, a liquid chamber, an oil chamber, a gas chamber, a mixing chamber and an analytical purifier.

Abstract: Provided are compounds of Formula I, compositions and methods for their use as inhibitors of alpha-kinase 1 (ALPK1).

Abstract: A monocrystalline SiC substrate comprising a first surface and a second surface. The first surface comprises pinning regions and a device region. Each of the pinning regions is configured to provide a potential well which is capable to attract dislocations from a region surrounding said pinning region. The device region is configured to provide a part of the monocrystalline SiC substrate for manufacturing a semiconductor device. The device region is surrounded by the pinning regions, and a density of dislocations in a central portion of the device region is smaller than a density of dislocations in an edge of the device region due to the pinning regions. The pinning regions surrounding the device region attracts dislocations of the device region into the edge portion, so that the density of dislocations in the central portion is reduced. A yield of the semiconductor devices is improved.

Abstract: A method for quality assurance may include obtaining a state of a medical device. The method may also include obtaining a target plan of a target subject. The method may also include determining a prediction result based on the state of the medical device and the target plan of the target subject. The method may also include determining whether a quality assurance test passes based on the prediction result.

Abstract: A system for generating a dose distribution is provided. The system may obtain a first dose distribution in at least a portion of a subject. The system may also obtain a trained machine learning model. The system may further generate, based on the first dose distribution and the trained machine learning model, a second dose distribution in the at least a portion of the subject, wherein the second dose distribution has a higher accuracy than that of the first dose distribution.

Abstract: A device for testing a needle roller bearing of a planet gear set consists of two identical helical planet gear sets, a piston, an end cover, a spindle, and can simulate the actual operating condition of a needle roller bearing of the planet gear set; the rotating speed difference between an inner raceway and an outer raceway of the needle roller bearing is determined by adjusting the rotating speed of a sun gear and a planet carrier; the load on the needle roller bearing includes a centrifugal load and a radial load, and the centrifugal acceleration and the centrifugal load are determined by adjusting the rotating speed of the planet carrier; a method of determining the radial load by adjusting the hydraulic pressure difference of hydraulic chambers at both ends of the piston, generating a tangential force to load the planet gear, and balancing the radial load of the bearing.

Abstract: The embodiments of the present disclosure provide a radiation therapy device. The radiation therapy device may comprise a beam generating device, a scanning magnet, and one or more focusing magnets. The beam generating device may be configured to generate a charged particle beam. The scanning magnet may be configured to diverge the charged particle beam. The one or more focusing magnets may be configured to deflect the charged particle beam diverged by the scanning magnet.

Abstract: The present disclosure relates a multi-leaf collimator. The multi-leaf collimator may include a plurality of leaves. At least two leaves of the plurality of leaves may be movable parallel to each another. For each leaf of at least some of the plurality of leaves, at least one portion of the leaf may have thicknesses varying along a longitudinal direction of the each leaf. The each leaf may have a first end and a second end along the longitudinal direction of the each leaf.

Abstract: The present disclosure relates to systems and methods for reconstructing fluence map. The system may obtain a plurality of radiation tasks based on a radiotherapy plan. Each of the plurality of radiation tasks may include a radiation field corresponding to the radiation task. For each of the plurality of radiation tasks, the system may determine whether a shape change between a radiation field corresponding to the radiation task and a radiation field corresponding to a preceding radiation task exceeds a shape change threshold. The system may determine a fluence map corresponding to the radiation task based on a first determination result of whether the shape change between the radiation field corresponding to the radiation task and the radiation field corresponding to the preceding radiation task exceeds the shape change threshold.

Abstract: A device for testing a needle roller bearing of a planet gear set consists of two identical helical planet gear sets, a piston, an end cover, a spindle, and can simulate the actual operating condition of a needle roller bearing of the planet gear set; the rotating speed difference between an inner raceway and an outer raceway of the needle roller bearing is determined by adjusting the rotating speed of a sun gear and a planet carrier; the load on the needle roller bearing includes a centrifugal load and a radial load, and the centrifugal acceleration and the centrifugal load are determined by adjusting the rotating speed of the planet carrier; a method of determining the radial load by adjusting the hydraulic pressure difference of hydraulic chambers at both ends of the piston, generating a tangential force to load the planet gear, and balancing the radial load of the bearing.

Abstract: The present disclosure provides a device and an equipment for radiation ray generation. The device may include: a radiation target assembly configured to generate radiation rays under irradiation of an electron beam with a predetermined energy; and a heat dissipation assembly arranged on a back surface of the radiation target assembly, wherein a range of a thickness of the target assembly may be determined based on a peak of energy deposition of a target material of the radiation target assembly under the irradiation of the electron beam with the predetermined energy.

Abstract: The present disclosure relates a multi-leaf collimator. The multi-leaf collimator may include a plurality of leaves. At least two leaves of the plurality of leaves may be movable parallel to each another. For each leaf of at least some of the plurality of leaves, at least one portion of the leaf may have thicknesses varying along a longitudinal direction of the each leaf. The each leaf may have a first end and a second end along the longitudinal direction of the each leaf.

Abstract: The embodiments of the present disclosure provide a system for determining a radiation dose. The system may include: obtaining data related to radiation source, a radiation auxiliary image of a target object at a target radiation time point, and an initial fluence map corresponding to the target radiation time point; determining a target fluence map corresponding to the target radiation time point by one or more iterations based on the radiation auxiliary image, the initial fluence map, and the data related to radiation source; obtaining a target scanning image of the target object; and determining the radiation dose received by the target object at the target radiation time point, based on the target fluence map, the target scanning image, and the data related to radiation source.

Abstract: One or more embodiments of the present disclosure relate to a radiotherapy target device. The radiotherapy target device may include: a target component including a target body and a support supporting the target body; and a housing surrounding the target component. The housing may include a first surface and a second surface allowing radiation beams to pass through.

Abstract: The present disclosure relates a multi-leaf collimator. The multi-leaf collimator may include a plurality of leaves. At least two leaves of the plurality of leaves may be movable parallel to each another. For each leaf of at least some of the plurality of leaves, at least one portion of the leaf may have thicknesses varying along a longitudinal direction of the each leaf. The each leaf may have a first end and a second end along the longitudinal direction of the each leaf.

Abstract: Systems and methods for a pre-treatment quality assurance (QA) of a radiotherapy device may be provided. The method may include determining a measured dose image through an electronic portal dose imaging device (EPID). The method may include determining an energy fluence distribution map related to radiation beams predicted by a first portal dose prediction model. The method may include determining a predicted dose image based on the energy fluence distribution map and a simulated energy response curve related to the EPID. The method may further include determining differences between the measured and predicted dose images by comparing the dose distributions of the measured and predicted dose images.