Abstract: Embodiments provided herein, provide for variant IgG Fc polypeptides, dimeric molecules, pharmaceutical compositions, and methods that can be used to target at cells to modulate the activity of the same to treat disorders, such as autoimmune disorders or cancers.

Abstract: A data processing method and system for a distributed database, and a device and a storage medium. The method comprises: sorting transactions in a transQueue by using a global timestamp TSO, creating a local transaction list by means of an XA Event and a waitTrans in the transQueue, and generating first-level sorting queues according to the local transaction list (102); for the first-level sorting queue of each DN, performing multi-path merging and sorting, so as to generate a global sorting queue (104); and for the global sorting queue, merging local transactions that have the same global timestamp TSO, and generating a global binary log Binlog (106). Therefore, the global orderliness and integrity of transactions during the process of processing and replicating data in a distributed database are ensured.

Abstract: Embodiments of the present application provide a data processing method, a distributed database system, an electronic device and a computer storage medium, wherein a data processing method is applied to a shard node of a distributed database system. The method comprises: receiving a physical DDL instruction converted from a logic DDL instruction for change of data in the distributed database system; executing the physical DDL instruction and generating a shard node mode snapshot for the shard node after the physical DDL instruction has been successfully executed; and if it is determined that the shard node mode snapshot is inconsistent with a global logic mode snapshot of the distributed database system, adjusting log data of the shard node aggregated into a global log to be consistent with the global logic mode snapshot.