Abstract: A multi-chip integrated circuit (IC) device includes a first IC chip, and a second IC chip. The second IC chip is connected to the first IC chip via interface circuitry. The second IC chip receives a clock signal and a track signal from the first IC chip. Further, the second IC chip outputs a first control signal to the first IC chip. The first control signal includes an indication to adjust the clock signal based on determining that the clock signal is not aligned with the track signal. The second IC chip receives the adjusted clock signal from the first IC chip.

Abstract: Systems and methods for reducing, by a link partner, backlog at a receiver buffer of the other link partner. Each link partner includes at least one circuit coupled between a data fabric and an interconnect link of an interconnect fabric. The at least one circuit includes a receiver configured to receive datagrams from the interconnect fabric and a transmitter configured to send datagrams over the interconnect fabric. The transmitter is configured to monitor a loop latency for datagrams communicated between the link partners over the interconnect fabric using toggling handshake codes in their headers. Based on the monitored loop latency for the datagrams, the transmitter of a link partner is configured to reduce a receiver buffer backlog at the other link partner. The loop latency monitoring can include monitoring an unloaded and loaded loop latencies and comparing a difference between the loop latencies to one or more thresholds.

Abstract: Systems and devices for packing one or more sequence numbers into datagrams for transmission to a link partner over an interconnect fabric, the link partners including a transmitter in communication with a receiver for data transmission over the interconnect link, each of the transmitter and the receiver including at least one circuit. The at least one circuit packages a header and a data payload into data packets for transmission to the other of the transmitter and the receiver. Responsive to a request from the transmitter or the receiver, the at least one circuit of the transmitter or the receiver encodes a first sequence number and a second sequence number into the header of the data packet for transmission to the other of the transmitter or the receiver. The first sequence number may be a transmitter sequence number, and the second sequence number may be a receiver sequence number.

Abstract: Provided herein are oligomeric compounds with conjugate groups targeting apoplipoprotein (a) [apo(a)]. In certain embodiments, the apo(a) targeting oligomeric compounds are conjugated to NAcetylgalactosamine. Also disclosed herein are conjugated oligomeric compounds targeting apo(a) for use in decreasing apo(a) to treat, prevent, or ameliorate diseases, disorders or conditions related to apo(a) and/or Lp(a). Certain diseases, disorders or conditions related to apo(a) and/or Lp(a) include inflammatory, cardiovascular and/or metabolic diseases, disorders or conditions. The conjugated oligomeric compounds disclosed herein can be used to treat such diseases, disorders or conditions in an individual in need thereof.

Abstract: Systems and devices for Universal Asynchronous Receiver Transmitter (UART) mode communication may include a first circuit including a first receiver transmitter in communication with a second receiver transmitter of a second circuit over an interconnect link. In a transmit direction, the first circuit is configured to pack stream transport data into data flits of a datagram for serialized transmission of data from the first receiver transmitter to the second receiver transmitter over the interconnect link. In a receive direction, the first circuit is configured to unpack the stream transport data from the data flits received as serialized data over the interconnect link from the second circuit of the second receiver transmitter. The stream transport data can be firmware data packed into the data flits as data link messages, which may be exchanged between firmware agents associated with the respective first circuit and second circuit.

Abstract: A broad-spectrum disease resistance-related protein derived from wheat and related biomaterials and use thereof are provided. The protein is selected from the group consisting of A1) a protein with the amino acid sequence of SEQ ID NO: 1; A2) a protein having more than 80% identity to, having a same function as the protein with the amino acid sequence of SEQ ID NO: 1, and obtained by substitutions and/or deletions and/or additions of amino acid residues thereof, and A3) a fusion protein with a same function obtained by joining a tag at N-terminus and/or C-terminus of A1) or A2). The TaCNGC5.1 overexpression lines showed significantly improved disease resistance, thus suggesting that TaCNGC5.1 may play an important role in breeding plants with improved resistance to stripe rust.

Abstract: A hypothermic oxygenated perfusion solution for repairing kidney injury and use thereof belongs to the technical field of medical treatment. The hypothermic oxygenated perfusion solution is an organ preservation solution carrying carbon monoxide-releasing molecules. The hypothermic oxygenated perfusion solution can significantly increase the perfusion flow of the kidney, reduce the intrarenal resistance and significantly improve the histopathological integrality. The hypothermic oxygenated perfusion solution is provided for specifically repairing the kidney from donation after circulatory death donors, and has a huge application prospect for clinical transformation.

Abstract: Various embodiments described herein support or provide for electrical disturbance testing, including establishing a communication session between an onboard unit and a roadside unit; generating a radio frequency signal to interfere with the communication session; detecting an interrupt of the communication session at a frequency point associated with the RF signal; determining that the interrupt is caused by a failure of uplink data transmission in the communication session; and adjusting a position of the roadside unit or adjusting a filter communicatively coupled between the roadside unit and the associated antenna to cause the communication session to be reestablished at the frequency point associated with the radio frequency signal.

Abstract: Various embodiments described herein support or provide for electrical disturbance testing, including establishing a communication session between an onboard unit and a roadside unit; generating a radio frequency signal to interfere with the communication session; detecting an interrupt of the communication session at a frequency point associated with the RF signal; determining that the interrupt is caused by a failure of uplink data transmission in the communication session; and adjusting a position of the roadside unit or adjusting a filter communicatively coupled between the roadside unit and the associated antenna to cause the communication session to be reestablished at the frequency point associated with the radio frequency signal.

Abstract: Data integrity checks for reducing communication latency is described. A transmitting endpoint transmits data to a receiving endpoint by generating an integrity tag for a first subset of data blocks and a second integrity tag for a second subset of data blocks. In implementations, the first and second integrity tags overlap at least one data block and are offset based on computational complexities of generating the integrity tags. A receiving endpoint generates comparison tags for each of the integrity tags and uses the comparison tags to validate an authenticity of received data. In response to validating the first and second integrity tags, data blocks covered by both the first and second integrity tags are released for use. Additional integrity tags are generated and validated for subsequent subsets of data blocks during data communication, thus reducing latency by offsetting times at which comparison tags are generated and validated.

Abstract: This application discloses a data processing method performed by a computer device. Obtained service data is inputted into a pre-trained model and an initial service model to obtain first fully-connected layer outputs of the pre-trained model and second fully-connected layer outputs of the initial service model. The pre-trained model and the initial service model construct modeling units with different granularities, first modeling units of the pre-trained model are matched with second modeling units of the initial service model, fully-connected layer outputs of the second modeling units have the same sequence length as fully-connected layer outputs of matched target first modeling units so that with the assistance of the pre-trained model, the target service model can be obtained through the initial service model, the knowledge distillation of the models including modeling units with different granularities is realized, thereby effectively improving the service performance of the service model.

Abstract: A method for improving wheat resistance to Fusarium head blight (FHB) by genome editing is provided, and further provided is use of TaCIPK14 protein or related biomaterial thereto in the regulation of plant resistance to FHB; the TaCIPK14 protein is TaCIPK14-4A protein (SEQ ID NO: 4), TaCIPK14-4B protein (SEQ ID NO: 5), and/or TaCIPK14-4D protein (SEQ ID NO: 6). TaCIPK14 knockout mutant plants are successfully obtained by simultaneously editing three alleles of TaCIPK14 in wheat using CRISPR-Cas9 gene editing technology. The TaCIPK14 knockout mutant shows resistance to inoculation with FHB pathogens, and the results of evaluation of major agronomic traits confirm that the TaCIPK14 knockout mutant reserves the major agronomic traits.

Abstract: The present disclosure provides a ribose-modified cap analog and a use thereof, and belongs to the technical field of chemical and biological engineering. The ribose-modified cap analog has a structure of formula (I). The ribose-modified cap analog described herein can improve the stability of mRNA and/or the translation efficiency of mRNA.

Abstract: Toggle and power reduction for chiplet links is described. In accordance with the described techniques, a mask is selected from a plurality of pre-generated masks based on a bit pattern of data to be transmitted from a first chiplet to a second chiplet via a chiplet link. Masked data are generated by applying the mask to the data at the first chiplet. The masked data are transmitted from the first chiplet to the second chiplet via the chiplet link; and the masked data are corrected at the second chiplet by inverting the mask at the second chiplet.

Abstract: The disclosed device can dynamically reassign wires of an interconnect among channels for more efficient utilization. If a first channel is over-utilized and one or more other channels are under-utilized, the device can dynamically temporarily reassign wires of the under-utilized channels to the over-utilized channel to increase throughput. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: Disclosed herein are Advanced RNA Targeting (ARNATAR) oligomeric compounds, thoughtfully designed compounds for inhibiting gene expression through the RISC pathway. Such compounds are useful in methods for reducing expression of certain genes, many of which are associated with a variety of diseases and disorders.

Abstract: The present invention relates to a conjugate of cell-penetrating peptide and melphalan and a formulation comprising the same. Specifically, the present invention relates to a conjugate formed by covalently linking cell-penetrating peptide derivative to melphalan, a formulation comprising the conjugate, a method for treating diseases with the conjugate, and the application of the formulation in treating diseases.

Abstract: A Beidou/GNSS-based real-time high-precision sea surface measurement method and a buoy, wherein by using free-to-use broadcast ephemeris freely broadcast by GNSS satellites, precise point positioning of China's Beidou satellites, and other high-precision service space signals, real-time centimeter-level element information comprising time, longitude, latitude, water level, wave height, wave period, wave direction, sea surface current velocity and direction, atmospheric water vapor content, and the like can be directly obtained. The information can be stored locally in a buoy or transmitted back by communication, and is suitable for real-time high-precision sea surface measurements in offshore and far-sea scenarios.

Abstract: A wave spectrum calculation method based on GNSS wave measuring buoy is provided, which includes: placing GNSS drift buoys in the sea, collecting buoy position data; then obtaining three-dimensional velocity data of ocean waves; performing high pass filtering on velocity data of a sliding window to remove noise signals and trend terms, retaining wave motion data; calculating a cross spectrum and wave direction spectrum. The present disclosure solves limitations of traditional GNSS measurement methods applied to ocean buoy wave measurement, such as limited observation distance, high cost, tedious measurement and average calculation accuracy, and a need for correction services. The measurement accuracy is high and no additional correction services are required, which is more suitable for wave measurement, the wave spectrum algorithm in this method can adapt to more complex observation environments and incorporate results of a velocity measurement algorithm into a matched wave spectrum algorithm.

Abstract: The present disclosure provides a ribose-modified cap analog and a use thereof, and belongs to the technical field of chemical and biological engineering. The ribose-modified cap analog has a structure of formula (I). The ribose-modified cap analog described herein can improve the stability of mRNA and/or the translation efficiency of mRNA.