Abstract: The present disclosure provides compositions and methods of treating a stroke in a subject. The method comprises blocking the opening of connexin 43 (Cx43) hemichannel in cells by, e.g., using a composition comprising an anti-Cx43 antibody.

Abstract: The present disclosure generally relates to compositions and methods for treating a disease or condition associated with insufficient opening of Cx43 hemichannels in osteocytes, preferably for treating cancer, cancer metastasis, osteosarcoma, osteoporosis, or osteopenia.

Abstract: The present disclosure generally relates to compositions and methods for treating a disease or condition associated with opening of Cx43 hemichannels in astrocytes or osteocytes, preferably for treating an inflammatory disease or condition or a neurodegenerative disease such as spinal cord injury.

Abstract: The present disclosure provides compositions and methods of treating osteoarthritis such as osteoarthritis in a subject. The method comprises blocking the opening of Cx43 hemichannel in chondrocytes by, e.g., using a composition comprising an anti-connexin 43 antibody.

Abstract: Disclosed are a squeezing peristaltic pump for continuous transfer and a fluid transfer method. The squeezing peristaltic pump for continuous transfer includes: a housing, a transmission part, a pressing unit, and a limiting plate, the limiting plate being securely connected to the housing, a hose being disposed between the pressing unit and the limiting plate, the pressing unit being driven by the transmission part to move reciprocally to press the hose; wherein the pressing unit includes a squeezing device and a compensating device, the squeezing device and the compensating device being sequentially arranged along an output direction of fluid in the hose, in operation, the transmission part is configured to drive the squeezing device and the compensating device to alternately squeeze the hose.

Abstract: The present disclosure provides compositions and methods of treating bone cancers, e.g., osteosarcoma in patients who previously failed at least one line of therapy for treatment of osteosarcoma. The method comprises promoting the opening of Cx43 hemichannel in osteocytes by, e.g., using a composition comprising an anti-connexin 43 antibody.

Abstract: The present disclosure relates to pharmaceutical compositions and methods for treating a disease or condition associated with opening of Cx43 hemichannels in astrocytes or osteocytes, preferably for treating an inflammatory disease or condition or a neurodegenerative disease such as spinal cord injury.

Abstract: The present invention relates to crystalline polymorphs of an echinocandin antifungal agent and novel methods for their preparation.

Abstract: Provided are compounds useful for treating of cancer and methods for treating of cancer, comprising administering to a subject in need thereof a compound described therein.

Abstract: The present disclosure relates to pharmaceutical compositions and methods for treating a disease or condition associated with opening of Cx43 hemichannels in astrocytes or osteocytes, preferably for treating an inflammatory disease or condition or a neurodegenerative disease such as spinal cord injury.

Abstract: The present disclosure relates to novel crystalline forms of ozanimod and preparation method thereof. The provided crystalline forms of ozanimod comprise crystalline form CS9, crystalline form CS10 and crystalline form CS11, and can be used for treating autoimmune diseases, particularly used for preparing drugs for treating multiple sclerosis and ulcerative colitis. The crystalline forms of the present disclosure have one or more advantages in solubility, stability, hygroscopicity and processability and provide new and better choices for the preparation of ozanimod drug product, and are very valuable for drug development.

Abstract: The present invention relates to four crystal forms of crisaborole in free form and the preparation method thereof. The present invention also relates to the pharmaceutical composition containing the crystal forms and the use thereof.

Abstract: The present invention relates to four crystal forms of crisaborole in free form and the preparation method thereof. The present invention also relates to the pharmaceutical composition containing the crystal forms and the use thereof.

Abstract: The present disclosure is directed to novel crystalline forms of ozanimod and ozanimod hydrochloride, as well as preparation method thereof. Said crystalline forms of ozanimod and ozanimod hydrochloride can be used for treating autoimmune diseases, particularly used for preparing drugs for treating multiple sclerosis and ulcerative colitis. The crystalline forms of the present disclosure have one or more advantages in solubility, melting point, stability, dissolution, bioavailability and processability and provide new and better choices for the preparation of ozanimod drug product, and are very valuable for drug development.

Abstract: The present disclosure relates to crystalline form CS1 and CS9 of a hypoxia-inducible factor prolyl hydroxylase inhibitor compound (I) GSK1278863, processes for preparation, and uses for preparing drugs treating and/or preventing anemia thereof.

Abstract: Provided are an elastomeric-hose-compressing part, a cartridge, and a roller assembly for a pump head of a peristaltic pump, and a pump head for a peristaltic pump. The elastomeric-hose-compressing part includes a surface for compressing the elastomeric hose which has an arcuate shape along its length direction, wherein the surface for compressing the elastomeric hose is provided with flanges oppositely arranged on two side portions of the elastomeric-hose-compressing part in the width direction, the width direction of the elastomeric-hose-compressing part is perpendicular to the length direction, and the surface for compressing the elastomeric hose is formed by a continuous surface or by a plurality of surfaces sequentially arranged along the length direction.

Abstract: The present disclosure generally relates to compositions and methods for treating a disease or condition associated with opening of Cx43 hemichannels in astrocytes or osteocytes, preferably for treating an inflammatory disease or condition or a neurodegenerative disease such as spinal cord injury.

Abstract: The present invention relates to four crystal forms of crisaborole in free form and the preparation method thereof. The present invention also relates to the pharmaceutical composition containing the crystal forms and the use thereof.

Abstract: A crystalline form of valbenazine ditosylate, processes for preparation thereof, a pharmaceutical composition containing the crystalline form, use of the crystalline form for preparing vesicular monoamine transporter 2 inhibitor drugs, and use of the crystalline form for preparing drugs treating tardive dyskinesia.

Abstract: Provided are an elastomeric-hose-compressing part, a cartridge, and a roller assembly for a pump head of a peristaltic pump, and a pump head for a peristaltic pump. The elastomeric-hose-compressing part includes a surface for compressing the elastomeric hose which has an arcuate shape along its length direction, wherein the surface for compressing the elastomeric hose is provided with flanges oppositely arranged on two side portions of the elastomeric-hose-compressing part in the width direction, the width direction of the elastomeric-hose-compressing part is perpendicular to the length direction, and the surface for compressing the elastomeric hose is formed by a continuous surface or by a plurality of surfaces sequentially arranged along the length direction.