Patents by Inventor Yanfeng Zhang

Yanfeng Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10167298
    Abstract: The present invention relates to novel Pseudopolymorphs of Compound A, compositions comprising at least one Pseudopolymorph of Compound A, and methods of using the Pseudopolymorphs of Compound A for preparing compositions useful for treating or preventing HCV infection in a patient, wherein Compound A has the structure.
    Type: Grant
    Filed: October 24, 2014
    Date of Patent: January 1, 2019
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Michael McNevin, Yong Liu, Ian Mangion, Alfred Lee, Joyce Stellabott, Benjamin D. Sherry, Gary Martin, Kung-I Feng, Scott Schultz, Ryan Cohen, Yanfeng Zhang
  • Publication number: 20180370951
    Abstract: Provided are compounds useful for treating of cancer and methods for treating of cancer, comprising administering to a subject in need thereof a compound described therein.
    Type: Application
    Filed: September 4, 2018
    Publication date: December 27, 2018
    Inventors: Samuel V. Agresta, Chong-Hui Gu, David Schenkein, Hua Yang, Liting Guo, Zhen Tang, Jianming Wang, Yanfeng Zhang, Yan Zhou
  • Patent number: 10155194
    Abstract: An apparatus for collecting carbon dioxide from flue gas of a power plant. The apparatus includes an absorption tower, a sedimentation pool including slanting boards, a regeneration tower, a gas-liquid separator, a desiccator, a compressor, and a condenser. A rich solution is adapted to flow from a bottom of the absorption tower into the sedimentation pool for stratification. A gas outlet of the gas-liquid separator is in series connection with the desiccator, the compressor, the condenser, and a liquid carbon dioxide storage tank.
    Type: Grant
    Filed: May 11, 2017
    Date of Patent: December 18, 2018
    Assignee: WUHAN KAIDI GENERAL RESEARCH INSTITUTE OF ENGINEERING & TECHNOLOGY CO., LTD.
    Inventors: Zhilong Wang, Yanfeng Zhang
  • Publication number: 20180354916
    Abstract: The present disclosure relates to a preparation method of a trisodium AHU-377 and Valsartan co-crystal hydrate Form II. The preparation method comprises: firstly, preparing a clear solution of trisodium AHU-377 and Valsartan, the solvent of the clear solution comprises an anti-solvent and a good solvent of the target product Form II, and the boiling point of the good solvent is lower than that of the anti-solvent; secondly, evaporating the solution under vacuum to remove the good solvent and water from the system; and finally, optionally adding seed crystals of Form II or not and replenishing a mixture of water and a carrier solvent for stirring for crystallization. The method of the present disclosure can prepare Form II successfully, and the process is consistent and controllable. The obtained Form II product has high chemical purity, crystalline purity and good flowability; and the process can be scaled up, and meets the requirements of large-scale production.
    Type: Application
    Filed: November 10, 2016
    Publication date: December 13, 2018
    Applicant: CRYSTAL PHARMATECH CO., LTD.
    Inventors: Minhua CHEN, Yanfeng ZHANG, Liang ZHANG
  • Patent number: 10143086
    Abstract: The invention provides transient devices, including active and passive devices that physically, chemically and/or electrically transform upon application of at least one internal and/or external stimulus. Incorporation of degradable device components, degradable substrates and/or degradable encapsulating materials each having a programmable, controllable and/or selectable degradation rate provides a means of transforming the device. In some embodiments, for example, transient devices of the invention combine degradable high performance single crystalline inorganic materials with selectively removable substrates and/or encapsulants.
    Type: Grant
    Filed: November 14, 2016
    Date of Patent: November 27, 2018
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: John A. Rogers, Seung-Kyun Kang, SukWon Hwang, Jianjun Cheng, Yanfeng Zhang, Hanze Ying
  • Patent number: 10138250
    Abstract: The present invention relates to novel crystalline forms of 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide (compound I), its salts, and process for preparation thereof. Crystalline forms in the present invention have good stability, low hygroscopicity, good processability, easy treatability and other favorable properties. In addition, the process is simple, low cost, and has an important value for future optimization and development of the drug.
    Type: Grant
    Filed: May 21, 2018
    Date of Patent: November 27, 2018
    Assignee: Crystal Pharmatech Co., Ltd.
    Inventors: Minhua Chen, Yanfeng Zhang, Xiaoyu Zhang
  • Patent number: 10138239
    Abstract: A preparation method of PCI-32765 crystalline form A, which comprises the following steps: 1) dissolving free base of PCI-32765 in a good solvent; 2) the solution prepared by Step 1) is dropwise added into an anti-solvent, stirred and added seed crystal of PCI-32765 Form A; Or the solution prepared by Step 1) is dropwise added into the suspension containing seed crystal of PCI-32765 Form A; 3) solution obtained by step 2) is continuously stirred and aged until crystal transformation is completed, then the crystal slurry is obtained; 4) crystal slurry in step 3) is filtered, washed, and dried to obtain the powder of PCI-32765 Form A. The preparation method of crystalline Form A provided by the present disclosure is a simple process and can be easily controlled, scaled up stably and conducted reliably. The process has high yield, good impurity removing capacity and is environmentally friendly.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: November 27, 2018
    Assignee: Crystal Pharmatech Co. LTD
    Inventors: Minhua Chen, Yanfeng Zhang, Liang Zhang, Shulin Ji
  • Patent number: 10131855
    Abstract: A method for pressurized pyrolysis of biomass in a pressurized pyrolysis furnace, including: 1) crushing and screening biomass; collecting biomass having desired particle sizes; and delivering the biomass having desired particle sizes to a pulse-type feeding system; 2) transporting the biomass to a pyrolysis furnace via the pulse-type feeding system; synchronously initiating microwave and a plasma torch, the microwave producing a microwave field in the pyrolysis furnace, working gas of the plasma torch being ionized for the first time to produce plasma jet entering the pyrolysis furnace; and 3) allowing the syngas generated in 2) to continue moving upwards and introducing the syngas out from the top of the pyrolysis furnace; chilling the syngas; introducing the syngas to a cyclone separator to separate residues; and then cooling and purifying the syngas using a cooling device and a purifying device, respectively, to produce clean syngas.
    Type: Grant
    Filed: May 28, 2016
    Date of Patent: November 20, 2018
    Assignee: WUHAN KAIDI ENGINEERING TECHNOLOGY RESEARCH INSTITUTE CO., LTD.
    Inventors: Yanfeng Zhang, Liang Zhang, Yilong Chen
  • Patent number: 10126019
    Abstract: A seasonal heat-cold energy storage and supply pool, including a salt-free solar pool at the upper layer and an energy storage pool at the lower layer. The salt-free solar pool and the energy storage pool are separately connected to a water source. The salt-free solar pool includes a pool bottom and a pool wall. The pool bottom of the salt-free solar pool functions as a top cover of the energy storage pool. The energy storage pool includes a wall and a bottom which are a composite layer. The energy storage pool is provided with a heat exchange coil configured to implement heat exchange in the energy storage pool for supplying heat and cold for an external user. The salt-free solar pool and the energy storage pool are communicated through controllable valves at the pool bottom of the salt-free solar pool.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: November 13, 2018
    Assignee: ZHONGYING CHANGJIANG INTERNATIONAL NEW ENERGY INVESTMENT CO., LTD.
    Inventors: Yilong Chen, Shuchuan Hu, Yanfeng Zhang
  • Patent number: 10119076
    Abstract: A gasifier including a vertically disposed furnace body, a feeder disposed in a middle part of the furnace body and communicating with the furnace body, one or two layers of microwave plasma generators, an external heater configured to supply external thermal energy for the gasifier, and a monitoring unit. The furnace body includes an upper nozzle for spraying vapor, a lower nozzle for spraying CO2/vapor, a syngas outlet disposed at a top of the furnace body. The upper nozzle for spraying vapor is disposed in a clearance zone of the furnace body, and the lower nozzle for spraying CO2/vapor is disposed in a bed zone of the furnace body. The monitoring unit is disposed close to the syngas outlet. The one or two layers of microwave plasma generators are disposed above the upper nozzle in the clearance zone of the gasifier.
    Type: Grant
    Filed: June 25, 2014
    Date of Patent: November 6, 2018
    Assignee: WUHAN KAIDI GENERAL RESEARCH INSTITUTE OF ENGINEERING & TECHNOLOGY CO., LTD.
    Inventors: Yilong Chen, Yanfeng Zhang, Minggui Xia, Liang Zhang
  • Patent number: 10106427
    Abstract: A method for preparing nano silica and nano calcium carbonate using rice hull ash and flue gas. The method includes: 1) adding rice hull ash to a sodium hydroxide solution, to yield a first mixed solution; stirring and heating the first mixed solution; then filtering the first mixed solution to yield a first filtrate; 2) adding the first filtrate to a reaction still, and diluting the first filtrate; adding polyethylene glycol as a dispersant to the reaction solution; introducing flue gas to the reaction solution; filtering the reaction mixture to yield a first filter cake and a second filtrate; washing the first filter cake to a neural pH, slurrying and drying the first filter cake to yield nano silica; and 3) mixing the second filtrate and a washing solution collected from 2); adding a calcium hydroxide solution to the reaction still, to yield nano calcium carbonate.
    Type: Grant
    Filed: June 22, 2016
    Date of Patent: October 23, 2018
    Assignee: ZHONGYING CHANGJIANG INTERNATIONAL NEW ENERGY INVESTMENT CO., LTD.
    Inventors: Yilong Chen, Yanfeng Zhang, Zhijiu Zhuo, Xingcai Zheng, Zhangjian Fang, Leiming Tao, Yuting Cheng
  • Patent number: 10093654
    Abstract: Provided are compounds useful for treating cancer and methods of treating cancer, comprising administering to a subject in need thereof a compound described herein.
    Type: Grant
    Filed: July 13, 2017
    Date of Patent: October 9, 2018
    Assignee: Agios Pharmaceuticals, Inc.
    Inventors: Samuel V. Agresta, Chong-Hui Gu, David Schenkein, Hua Yang, Liting Guo, Zhen Tang, Jianming Wang, Yanfeng Zhang, Yan Zhou
  • Publication number: 20180282342
    Abstract: The present invention relates to novel crystalline forms of 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide(compound I), its salts, and process for preparation thereof. Crystalline forms in the present invention have good stability, low hygroscopicity, good processability, easy treatability and other favorable properties. In addition, the process is simple, low cost, and has an important value for future optimization and development of the drug.
    Type: Application
    Filed: May 21, 2018
    Publication date: October 4, 2018
    Inventors: Minhua Chen, Yanfeng Zhang, Xiaoyu Zhang
  • Publication number: 20180265495
    Abstract: The present invention relates to novel crystalline forms of Neratinib maleate and the preparation method thereof. The maleate novel crystalline forms of compound of Formula (I) in the present invention have high solubility, good stability, good processability, easy post-treatment process and other favorable properties. The preparation method is simple, low cost, and has an important value for future optimization and development of the drug.
    Type: Application
    Filed: January 8, 2016
    Publication date: September 20, 2018
    Applicant: CRYSTAL PHARMATECH CO., LTD
    Inventors: Minhua CHEN, Yanfeng ZHANG, Xiaojuan DIAO, Xiaoyu ZHANG
  • Patent number: 10077407
    Abstract: A biomass gasification system. The system includes: a) a gasifier; b) a waste heat exchanger; c) a waste heat boiler; d) a cyclone separator; e) a gas scrubber; f) a shift reactor; g) a desulfurizing tower; h) a first decarburizing tower; i) a synthesizing tower; and j) a second decarburizing tower. In the system, the gasifier, the waste heat exchanger, the cyclone separator, the gas scrubber, the shift reactor, the desulfurizing tower, the first decarburizing tower, the synthesizing tower, and the second decarburizing tower are connected sequentially. In addition, CO2 outlets of the first decarburizing tower and the second decarburizing tower are both connected to a cold medium inlet of the waste heat exchanger; and a cold medium outlet of the waste heat exchanger is connected to a gasifying agent entrance of the gasifier.
    Type: Grant
    Filed: September 11, 2016
    Date of Patent: September 18, 2018
    Assignee: WUHAN KAIDI ENGINEERING TECHNOLOGY RESEARCH INSTITUTE CO., LTD.
    Inventors: Yanfeng Zhang, Liang Zhang, Minggui Xia, Wenyan Liu
  • Patent number: 10072530
    Abstract: A hybrid power generation system using solar energy and bioenergy, including a solar thermal boiler system, a biomass boiler system, and a turbogenerator system. The solar thermal boiler system includes a trough solar collector, a heat collector, an oil circulating pump, a storage tank for storing heat transfer oil, a solar thermal heater, a solar thermal evaporator, a main pipe transporting saturated steam, and an auxiliary boiler. Heat transfer oil output from a solar light field of the solar thermal boiler system is transmitted through and transfers heat to the solar thermal evaporator and the solar thermal heater, and the heat transfer oil returns to the storage tank for storing heat transfer oil. The heat transfer oil in the storage tank is pumped to the solar light field via the oil circulating pump.
    Type: Grant
    Filed: October 11, 2016
    Date of Patent: September 11, 2018
    Assignee: WUHAN KAIDI ENGINEERING TECHNOLOGY RESEARCH INSTITUTE CO., LTD.
    Inventors: Yilong Chen, Yanfeng Zhang, Wenyan Liu
  • Publication number: 20180230136
    Abstract: The present disclosure provides crystalline form A of 3-(6-(1-(2, 2-difluorobenzo [d] [1, 3] dioxo-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic acid and process of preparation thereof. The crystalline form A has low hygroscopicity, good stability, is convenient to store. It has higher solubility than that of prior art and therefore plays an important role in further optimization and development of the drug.
    Type: Application
    Filed: August 11, 2016
    Publication date: August 16, 2018
    Applicant: CRYSTAL PHARMATECH CO., LTD.
    Inventors: Minhua CHEN, Yanfeng ZHANG, Kai LIU, Po ZOU, Xiaoyu ZHANG
  • Patent number: 10036592
    Abstract: A method for drying biomass fuel, including: 1) collecting and cutting raw biomass fuel into fragments; mechanically squeezing and dehydrating the fragments to yield biomass fuel in the form of filter cake; 2) mashing and loosening the biomass fuel in the form of filter cake; and loading the biomass fuel onto charging carriages of fuel transport vehicles; 3) connecting tails of the fuel transport vehicles and the carrier vehicle of drying equipment; moving the movable drying room of the carrier vehicle of drying equipment onto the fuel transport vehicles; 4) convectively drying the biomass fuel in the charging carriages; 5) exhausting air in the movable drying room following convective drying; and 6) moving the movable drying room to cover and seal the charging carriages of a next fuel transport vehicle following radiant drying. A mobile device for drying biomass fuel is also provided.
    Type: Grant
    Filed: May 27, 2017
    Date of Patent: July 31, 2018
    Assignee: ZHONGYING CHANGJIANG INTERNATIONAL NEW ENERGY INVESTMENT CO., LTD.
    Inventors: Yilong Chen, Shuchuan Hu, Yanfeng Zhang
  • Publication number: 20180201589
    Abstract: Novel crystalline forms of trisodium [3-((1S,3R)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl) propionate-(S)-3?-methyl-2?-(pentanoyl{2?-(tetrazol-5-ylate)biphenyl-4?-ylmethyl}amino)butyrate] hydrate, methods for their preparation, pharmaceutical compositions comprising these new forms, and use of them for treating or delaying progression or onset of diseases or disorders related to activity of angiotensin receptor 1 (AT1) blockage and neprilysin (NEP) inhibition, such as heart failure, are disclosed.
    Type: Application
    Filed: March 18, 2018
    Publication date: July 19, 2018
    Inventors: Minhua CHEN, Yanfeng ZHANG, Chaohui YANG, Xiaoyu ZHANG
  • Patent number: 10018415
    Abstract: An integrated solar energy drying system, including: a solar greenhouse, a solar energy storage bed, an air condenser, a wet dust collector, pipes, valves, and blowers. The solar greenhouse includes: a top side, three sunny sides, a shady side, floorboards, a gas inlet, and two gas outlets. The solar energy storage bed includes: an upper air box, a lower air box, a plurality of solar heat collecting-storing pipes, and a sealing chamber. Each solar heat collecting-storing pipe includes an air pipe. The air condenser includes: an air inlet, an air outlet, two gas chambers, and a bundle of gas pipes. The solar greenhouse, the solar energy storage bed, the air condenser, the wet dust collectors are connected via pipes. The valves and the blowers are disposed on the pipes.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: July 10, 2018
    Assignee: ZHONGYING CHANGJIANG INTERNATIONAL NEW ENERGY INVESTMENT CO., LTD.
    Inventors: Yilong Chen, Shuchuan Hu, Yanfeng Zhang