Patents by Inventor Yang-Chang Wu

Yang-Chang Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190255012
    Abstract: This invention is announcing a composition of flavonoid skeleton in the formula I or formula II compound, wherein each of the substituents is given the definition as set forth in the specification and claims. This composition has the capacity to treating or preventing a virus infection in a subject.
    Type: Application
    Filed: December 21, 2018
    Publication date: August 22, 2019
    Applicant: Kaohsiung Medical University
    Inventors: Hui-Chun WANG, Yang-Chang Wu, Fang-Rong Chang, Chin-Chung WU
  • Patent number: 10195176
    Abstract: This invention is announcing a composition of flavonoid skeleton in the formula I or formula II compound, wherein each of the substituents is given the definition as set forth in the specification and claims. This composition have the capacity to treating or preventing a virus infection in a subject.
    Type: Grant
    Filed: January 30, 2018
    Date of Patent: February 5, 2019
    Assignee: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Hui-Chun Wang, Yang-Chang Wu, Fang-Rong Chang, Chin-Chung Wu
  • Patent number: 10098853
    Abstract: Disclosed are a composition for preventing and treating atherosclerosis which includes chalcone compound. In particular, the chalcone compound bound with 2-hydroxyl in ring A and 4?-methyoxy in ring B has versatile therapeutic potentials on anti-atherosclerosis by acting as PPAR? inducer, p44/42 MAPK inhibitor and cell cycle blocker and does not show toxicity to human aortic smooth muscle cells (HASMCs). In addition, the chalcone compound exhibits synergistic effect with the PPAR? ligand (rosiglitazone) to inhibit cell proliferation and the upregulation of cyclin D1, cyclin D3, interleukin-1? (IL-1?) and interleukin-6 (IL-6) induced by oxidized low density lipoprotein (Ox-LDL).
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: October 16, 2018
    Assignee: Kaohsiung Medical University
    Inventors: Yang-Chang Wu, Fang-Rong Chang, Tusty-Jiuan Hsieh, Suh-Hang Juo, An-Shen Lin, Ying-Chi Du
  • Publication number: 20180161303
    Abstract: This invention is announcing a composition of flavonoid skeleton in the formula I or formula II compound, wherein each of the substituents is given the definition as set forth in the specification and claims. This composition have the capacity to treating or preventing a virus infection in a subject.
    Type: Application
    Filed: January 30, 2018
    Publication date: June 14, 2018
    Applicant: Kaohsiung Medical University
    Inventors: Hui-Chun WANG, Yang-Chang Wu, Fang-Rong Chang, Chin-Chung WU
  • Patent number: 9918962
    Abstract: This invention is announcing a composition of flavonoid skeleton in the formula I or formula II compound, wherein each of the substituents is given the definition as set forth in the specification and claims. This composition have the capacity to treating or preventing a virus infection in a subject.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: March 20, 2018
    Assignee: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Hui-Chun Wang, Yang-Chang Wu, Fang-Rong Chang, Chin-Chung Wu
  • Patent number: 9895329
    Abstract: Disclosed herein are novel formyl peptide receptor 1 (FPR1) antagonists and their uses in manufacturing medicaments for the treatment and/or prophylaxis of diseases and/or disorders mediated by FPR1.
    Type: Grant
    Filed: December 28, 2016
    Date of Patent: February 20, 2018
    Inventors: Tsong-Long Hwang, Yung-Fong Tsai, Chun-Yu Chen, Liang-Mou Kuo, Yuan-Bin Cheng, Chih-Hsin Wang, Fang-Rong Chang, Yang-Chang Wu
  • Publication number: 20170266250
    Abstract: The present invention relates to phorbol esters from the seeds of Aquilaria malaccensis by a series of chromatographic processes, and compositions containing these congeners for the treatment or prevention of allergic responses. Furthermore, compositions are provided which comprise these phorbol esters in combination with at least one to assess the effects for preventing or treating allergies.
    Type: Application
    Filed: June 13, 2016
    Publication date: September 21, 2017
    Inventors: FANG-RONG CHANG, BING-HUNG CHEN, HSUE-YIN HSU, YANG-CHANG WU, CHEN HSIEH, HUI-PING HSIEH
  • Publication number: 20170252393
    Abstract: The Toona sinensis extract of the present invention is prepared using supercritical fluid technique, wherein the method includes steps of: (a) drying the leaves of T. sinensis; (b) pulverizing the leaves as particles; and (c) extracting the particles with supercritical carbon dioxide to obtain the T. sinensis extract. This supercritical T. sinensis extract not only can decrease blood sugar level, but also promotes lipid degradation, inhibits the formation of huge lipid droplet and improves the metabolic symptoms. Accordingly, the T. sinensis extract further is able to be prepared as food supplement and pharmaceuticals.
    Type: Application
    Filed: May 16, 2017
    Publication date: September 7, 2017
    Applicants: Metal Industries Research & Development Centre, Kaohsiung Medical University
    Inventors: Pei-Jung Lien, Chuan-Chia Sun, Tzu-Chen Kuo, Sheng-Chung Yang, Yang-Chang Wu, Fang-Rong Chang, Tusty-Jiuan Hsieh, Yi-Hung Tsai, Ying-Chi Du
  • Publication number: 20170226150
    Abstract: Disclosed are the isolation, purification and analysis of the triterpenoid compositions (including ergostane and lanostane) in the fruiting body of Antrodia cinnamomea using HPLC and NMR, as well as the stereo structures and the amounts of the triterpenoid compositions. The cytotoxicity of triterpenoids is also revealed. Based on the aforementioned techniques, the presence and amounts of ergostane and lanostane in the drugs, healthcare food or other goods are able to be detected.
    Type: Application
    Filed: April 28, 2017
    Publication date: August 10, 2017
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: YANG-CHANG WU, FANG-RONG CHANG, MEI-CHIN LU, YING-CHI DU, TUNG-YING WU, YU-MING HSU
  • Patent number: 9718835
    Abstract: The present invention is related to novel 20-sulfonylamidine derivatives of camptothecin (1), method of synthesizing the same, and use thereof as an antitumor agent, for examples an antitumor agent for treating nasopharyngeal, lung, breast or prostate cancer.
    Type: Grant
    Filed: September 26, 2014
    Date of Patent: August 1, 2017
    Assignees: CHINA MEDICAL UNIVERSITY HOSPITAL, THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
    Inventors: Kuo-Hsiung Lee, Keduo Qian, Xiaoming Yang, Masuo Goto, Ying-Qian Liu, Yong-Long Zhao, Liu Yang, Mei-Juan Wang, Zhi-Jun Zhang, Tian-Shung Wu, Che-Ming Teng, Chih-Ya Wang, Shiow-Lin Pan, Sheng-Chu Kuo, Hsin-Yi Hung, Ling-Chu Chang, Yang-Chang Wu, Min-Tsang Hsieh, Chung Y. Hsu, Woei-Cherng Shyu, Chen-Huan Lin
  • Publication number: 20160318972
    Abstract: An optimal preparation and analytic method for the extraction of Antrodia cinnamomea is disclosed. The important parameters for the extraction efficiency of the extract are analyzed using mathematic and statistical experimental designs, and the extract of A. cinnamomea and its particular triterpenoid compounds are quantified and identified using the quantitative NMR and HPLC-tandem MS. Whether the ergostane and lanostane triterpenoid compounds are contained in one drug, health food or other products and the total amounts and individual amounts therein can be analyzed, determined or quantified using the techniques disclosed herein.
    Type: Application
    Filed: April 29, 2016
    Publication date: November 3, 2016
    Inventor: YANG-CHANG WU
  • Publication number: 20160229862
    Abstract: The present invention is related to novel 20-sulfonylamidine derivatives of camptothecin (1), method of synthesizing the same, and use thereof as an antitumor agent, for examples an antitumor agent for treating nasopharyngeal, lung, breast or prostate cancer.
    Type: Application
    Filed: September 26, 2014
    Publication date: August 11, 2016
    Inventors: Kuo-Hsiung LEE, Keduo QIAN, Xiaoming YANG, Masuo GOTO, Ying-Qian LIU, Yong-Long ZHAO, Liu YANG, Mei-Juan WANG, Zhi-Jun ZHANG, Tian-Shung WU, Che-Ming TENG, Chih-Ya WANG, Shiow-Lin PAN, Sheng-Chu KUO, Hsin-Yi HUNG, Ling-Chu CHANG, Yang-Chang WU, Min-Tsang HSIEH, Chung Y. HSU, Woei-Cherng SHYU, Chen-Huan LIN
  • Publication number: 20160214918
    Abstract: A compound for treating a metabolic syndrome, comprising a structure of a 6Cs unit-3Cs unit-6Cs unit (C6-C3-C6) as shown in formula I, wherein: when R1 and R2 are both hydrogens, C3 has only single bonds; when R1 is an oxygen and R2 is one selected from a group consisting of an alkoxy, a benzyloxy and a halogen, C3 has only single bonds; when R1 is a deuterium and R2 is one selected from a group consisting of a hydrogen, an alkoxy, a benzyloxy and a halogen, C3 has one of a single bond and a double bond.
    Type: Application
    Filed: January 21, 2016
    Publication date: July 28, 2016
    Applicant: Kaohsiung Medical University
    Inventors: Fang-Rong Chang, Yang-Chang Wu, Tusty-Jiuan Hsieh, Chi-Ting Hsieh, Ferenc Fülöp, Sándor Balázs Ötvös
  • Publication number: 20160158190
    Abstract: This invention is announcing a composition of flavonoid skeleton in the formula I or formula II compound, wherein each of the substituents is given the definition as set forth in the specification and claims. This composition have the capacity to treating or preventing a virus infection in a subject.
    Type: Application
    Filed: February 5, 2016
    Publication date: June 9, 2016
    Applicant: Kaohsiung Medical University
    Inventors: Hui-Chun WANG, Yang-Chang Wu, Fang-Rong Chang, Chin-Chung WU
  • Patent number: 9341605
    Abstract: Disclosed are a method for analyzing chemical profiles of components from a herbal medicine product. Components may include quinone (including rhein, sennoside A and/or aloe-emodin), stilbene containing resveratroloside, flavone including baicalin, and/or alkaloid including berberine and/or palmatine. The method includes steps of: (a) respectively chromatographing a methanol extract of product and standard(s) corresponding to the component(s) using HPLC; (b) comparing HPLC chromatogram of extract and standard(s); and (c) analyzing the chemical profiles of the product from the comparison results.
    Type: Grant
    Filed: June 20, 2012
    Date of Patent: May 17, 2016
    Assignee: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Fang-Rong Chang, Tung-Ying Wu, Yang-Chang Wu
  • Patent number: 9241962
    Abstract: A preparation method for a water extract of the fruiting body of Antrodia camphorata (ACW) is provided. The method includes steps of: (a) providing the fruiting body; and (b) boiling the fruiting body in water to obtain the water extract. This polysaccharide-rich water extract from A. camphorata induces the maturation of dendritic cells, enhances T cell proliferation and INF-? production, and polarizes them toward the Th1 pathway. ACW can be effectively applied in cancer immunotherapy.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: January 26, 2016
    Assignee: Kaohsiung Medical University
    Inventors: Yang-Chang Wu, Mei-Chin Lu, Fang-Rong Chang, Ying-Chi Du, Tung-Ying Wu
  • Patent number: 9085520
    Abstract: Disclosed is a chalcone composition for treating diabetes and metabolic syndromes. In particular, the chalcone compound bound with 2-halogen in ring A significantly decreases the blood glucose level in the in vitro anti-diabetic effect experiment. In the in vivo animal model, the leading chalcone compound can prevent the progression of diabetes and control the blood glucose level, and there is no significant difference in the gains in body weight. Throughout the seven-week administration, there are no hepatic or renal toxicity observed.
    Type: Grant
    Filed: August 8, 2012
    Date of Patent: July 21, 2015
    Assignee: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Yang-Chang Wu, Fang-Rong Chang, Tusty-Jiuan Hsieh, Ying-Chi Du, Yi-Hong Tsai, Chi-Ting Hsieh
  • Patent number: 9045437
    Abstract: Provided is a compound of the formula I or a pharmaceutically acceptable salt, solvate or stereoisomer thereof: wherein Ar represents R5, R7, R8, R2?, R3?, R4?, R5?, R6?, R7?, R8? independently represent H, OH, F, Cl, Br methoxyl group, NH2 group or NMe2 group; X represents NH, O or S; R6 is selected from the group consisting of: piperidinyl group, morpholino group, methoxyl group, and dimethylamine group. The present invention also provides a composition comprising the compound of formula I. The compound and the composition in accordance with the present invention are effective on treating or alleviating a disease or disorder, such as malignant glioma.
    Type: Grant
    Filed: July 30, 2013
    Date of Patent: June 2, 2015
    Assignee: China Medical University
    Inventors: Mann-Jen Hour, Po-Wu Gean, Sheng-Chu Kuo, Hong-Zin Lee, Jai-Sing Yang, Li-Chen Chou, Tai-Lin Chen, Yang-Chang Wu
  • Publication number: 20150104481
    Abstract: A preparation method for a water extract of the fruiting body of Antrodia camphorata (ACW) is provided. The method includes steps of: (a) providing the fruiting body; and (b) boiling the fruiting body in water to obtain the water extract. This polysaccharide-rich water extract from A. camphorata induces the maturation of dendritic cells, enhances T cell proliferation and INF-? production, and polarizes them toward the Th1 pathway. ACW can be effectively applied in cancer immunotherapy.
    Type: Application
    Filed: December 19, 2014
    Publication date: April 16, 2015
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Yang-Chang Wu, Mei-Chin Lu, Fang-Rong Chang, Ying-Chi Du, Tung-Ying Wu
  • Patent number: 9006239
    Abstract: Provided is a compound of the formula I or a pharmaceutically acceptable salt, solvate or stereoisomer thereof: wherein Ar represents R5, R7, R8, R2?, R4?, R5?, R6?, R7?, R8? independently represent H, OH, F, Cl, Br, methoxyl group, NH2 group or NMe2 group; X represents NH, O or S; and R6 is selected from the group consisting of: pyrrolidinyl group, piperidinyl group, morpholino group, methoxyl group, and dimethylamine group. The present invention also provides a composition comprising the compound of formula I. The compound and the composition in accordance with the present invention are effective on treating or alleviating a disease or disorder, such as malignant glioma.
    Type: Grant
    Filed: July 30, 2013
    Date of Patent: April 14, 2015
    Assignee: China Medical University
    Inventors: Mann-Jen Hour, Po-Wu Gean, Sheng-Chu Kuo, Hong-Zin Lee, Jai-Sing Yang, Li-Chen Chou, Tai-Lin Chen, Yang-Chang Wu