Abstract: Provided herein are compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, compositions, and mixtures thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating and/or preventing diseases (e.g., proliferative diseases (e.g., cancers, such as carcinoma, sarcoma, lung cancer, thyroid cancer, skin cancer, ovarian cancer, colorectal cancer, prostate cancer, pancreatic cancer, esophageal cancer, liver cancer, breast cancer)) in a subject. Provided are methods of inhibiting a TEAD transcription factors (e.g., TEAD1, TEAD2, TEAD3, TEAD4) in a subject.

Abstract: Compositions and methods for altering flowering and/or maturity time of soybean plant are provided. Compositions include isolated and recombinant polynucleotides encoding polypeptides, expression cassettes, host cells, plants, plant parts stably incorporating these polynucleotides. Methods and kits are provided for producing these plants via transgenic means, breeding or genomic editing approaches and identify plants having altered flowering and/or maturity time.

Abstract: A single-phase immersion liquid cooling system, a liquid cooling method, and a storage medium are provided.

Abstract: This application relates to a precomputed cell display method and apparatus, a computer device, a computer-readable storage medium, and a computer program product. The method includes: displaying, in response to a view space division event triggered for a virtual scene in which a virtual character is located, a limited-view space and a full-view space that are obtained through division in the virtual scene; displaying, corresponding to a navigation mesh of a first space in the limited-view space, a plurality of precomputed cells that extend in a standing direction of the virtual character and that cover the navigation mesh; and displaying, corresponding to a static mesh of a second space in the full-view space, a plurality of precomputed cells that extend in the standing direction of the virtual character and that cover the static mesh of the second space.

Abstract: The present invention provides a system with an MCU and flash memory and a method for DPD control thereof. A new DPD mode (first DPD mode) is provided by simply adding a power supply pin to the MCU. The power supply pin is coupled to a power supply terminal of the flash memory. In a deep power down mode, the flash memory is configured to be entirely powered down, leading to even lower system power consumption than in a conventional DPD mode (second DPD mode).

Abstract: Disclosed is a method and device for predicting inlet NOx concentration of a denitrification system in a thermal power plant considering measurement delay.

Abstract: Provided herein are bifunctional compounds with a moiety (e.g., lenalidomide, thalidomide) that is a binder of an E3 ubiquitin ligase (e.g., Cereblon) and another moiety that is a binder of a target protein (e.g., kinase (e.g., CDK (e.g., CDK9 and/or CDK12))) to induce degradation of the target protein CDK9 and/or CDK12. Also provided are pharmaceutical compositions comprising the bifunctional compounds, and methods of treating and/or preventing diseases (e.g., proliferative diseases, such as cancers (e.g., ovarian cancer, breast cancer, or prostate cancer))). Provided also are methods of inducing the degradation of the target protein (e.g., kinase (e.g., CDK (e.g., CDK9 and/or CDK12))), and methods of inducing apoptosis in a cell in a biological sample or subject by administering the bifunctional compound or composition described herein.

Abstract: The present disclosure relates to the technical field of display, and provides a thin-film light-emitting device and a display panel. The thin-film light-emitting device includes an anode, a hole transport layer, a light-emitting layer, and a cathode which are sequentially stacked. The hole transport layer includes a hole transport material and a triplet quenching material, and the triplet quenching material can quench at least some of triplet excitons in the hole transport material.

Abstract: A compound of formula A which is used as an anti-aging agent, a rubber composition comprising the compound of formula A, and a method of using the compound in the rubber composition are provided. The rubber composition of the present invention is used as an entire or partial rubber matrix of a tire, especially as a tire belt rubber. The anti-aging agent of the present invention can provide good rubber-steel wire adhesion performance, improve the thermal oxidative aging resistance of the rubber composition, and especially improve the mechanical properties and adhesion properties after aging in the presence of metal ions, prolonging the service life of tires.

Abstract: A control circuit of a large data processing device system for virtual currency and a large data processing device for virtual currency using the control circuit. The control circuit includes: at least two co-controllers (12), each of the co-controllers (12) being in communication connection with one hashboard group (14), to communicate with the connected hashboard group (14) and control operation of the connected hashboard group (14); and a main controller (11) in communication connection with each of the co-controllers (12), to receive and submit tasks and perform, according to the received tasks, coordinated control and task allocation on each of the co-controllers (12), each of the hashboard groups (14) including at least one hashboard.

Abstract: In one embodiment, a method includes receiving a voice input having first audio features at a client system, generating a text response corresponding to the voice input, wherein the text response is associated with style features, generating an output audio waveform of the text response by a text-to-speech model on the client system, wherein the output audio waveform is generated based on the first audio features and the style features, wherein the output audio waveform comprises second audio features, and rendering the output audio waveform at the client system in response to the voice input.

Abstract: Provided herein are compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopologues, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating and/or preventing diseases (e.g., proliferative diseases (e.g., cancers and benign neoplasms), inflammatory diseases (e.g., rheumatoid arthritis), and vascular diseases (e.g., atherosclerosis) in a subject. Provided are methods of inhibiting a INK (e.g., JNK1, JNK2, or JNK3) in a subject.

Abstract: A fatigue- and aging-resistant rubber composition and the method of use thereof are provided. The formulation of the rubber composition comprises 100 parts by mass of a diene elastomer and 1-3 parts by mass of a compound of formula A. The compound of formula A is as follows: which significantly improves the fatigue and aging resistance of the rubber composition and prolongs the service life of rubber products.

Abstract: A compound of formula A, which can be used as an antioxidant, an antioxidant composition comprising the compound of formula A and an antioxidant STMQ, a rubber composition comprising the antioxidant composition or the compound of formula A, and a method of use of the rubber composition are provided. The compound of formula A has the following structure: and the antioxidant and the antioxidant composition of the present invention significantly improve the damp-heat aging resistance of a tire rubber material and have good ozone aging resistance, thereby prolonging the service life of a tire in special and harsh environments.

Abstract: An antioxidant composition comprising two or more compounds of formula A, a rubber composition comprising the antioxidant composition, and a method of use of the rubber composition are provided. The structure of the compounds of formula A is as follows: The antioxidant composition significantly improves the static ozone aging resistance and dynamic ozone aging resistance of a tire rubber material, and the other properties thereof such as thermo-oxidative aging resistance can also be kept consistent with existing comprehensive antioxidants.

Abstract: Disclosed is a method for pretreating Ranitidine hydrochloride sample, comprising steps: S1, weighing the Ranitidine hydrochloride sample containing an impurity of N-nitrosodimethylamine; S2, preparing a test solution of Ranitidine hydrochloride so that the concentration of N-nitrosodimethylamine in the test solution reaches the detection limit of high-performance liquid chromatography; S3, adding an alkaline solution to the Ranitidine hydrochloride test solution, wherein the alkaline solution reacts completely with hydrochloric acid in Ranitidine hydrochloride to give a Ranitidine neutralizing solution; S4, adding a silver ion solution to the Ranitidine neutralizing solution, and silver ions undergo a complete complexation reaction with secondary amino groups in Ranitidine to generate a precipitate.