Abstract: Provided herein are compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, compositions, and mixtures thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating and/or preventing diseases (e.g., proliferative diseases (e.g., cancers, such as carcinoma, sarcoma, lung cancer, thyroid cancer, skin cancer, ovarian cancer, colorectal cancer, prostate cancer, pancreatic cancer, esophageal cancer, liver cancer, breast cancer)) in a subject. Provided are methods of inhibiting a TEAD transcription factors (e.g., TEAD1, TEAD2, TEAD3, TEAD4) in a subject.

Abstract: In an approach to building a file system for multiple architectures, responsive to receiving a manifest for a file system build, a base layer is retrieved for each platform to be built, where the base layer is an operating system base. Responsive to determining that any layer to be built has not been built, the next layer to be built is retrieved. Responsive to the next layer to be built is platform-independent, the next layer is retrieved from a cache, where the next layer supports each platform. Responsive to the next layer to be built is platform-dependent, the next layer is built, where a copy of the next layer is built for each platform. The above steps are iteratively repeated until each layer is built. A single image of a completed file system build is stored, where the single image supports each platform.

Abstract: Provided is a method for reverse real-time matching based on event-driven graph patterns. The method includes definition of a graph pattern, establishment of reverse matching architecture and a reverse matching method; and the graph pattern is used for describing a spatial connection relationship among vertices and edges in a graph in a reverse order and attribute constraints thereof, and includes a linked list of matching steps and matching contexts. Reverse real-time matching of the graph pattern is realized according to the reverse matching architecture, and the problem of event-driven subgraph matching in a real-time scene is solved.

Abstract: Method to generate frames on demand starts with a system receiving a request for a media content item from a client device. The request includes a media content identification and a main user identification. The system transmits to the client device a playlist including a first set of media content item segments. While the first set of media content item segments is being displayed on the client device, the system renders a second set of media content item segments using the media content identification and the main user identification. Rendering the second set of media content item segments can include rendering a main user avatar based on the main user identification and incorporating the main user avatar into the second set of media content item segments. The system then updates the playlist to include the second set of media content item segments. Other embodiments are disclosed herein.

Abstract: Provided is an aggregation index structure and an aggregation index method for improving aggregation query efficiency. The aggregation index partitions streaming data through two dimensions of grouping and slicing, and then aggregates the partitioned data. The structure includes index metadata, a sliced data list and a detailed data store; the aggregation index method includes three parts: aggregation index definition, aggregation index creation and aggregation index query. The aggregation index structure and method provided by the present disclosure can greatly improve the efficiency of aggregation query, support the ad hoc aggregation query of PB-level data, complete the aggregation query of a large amount of data in seconds, support the insertion of new data at any time, and return the query results in minutes or even seconds latency in the event of changes of the query range conditions.

Abstract: Disclosed a combined rock-breaking TBM tunneling method in complex strata for realizing three-way force detection, comprising the steps of preparing a combined mechanical-hydraulic rock-breaking cutter head for TBM construction; starting construction; advancing the combined mechanical-hydraulic rock-breaking cutter head; pushing and pressing against a tunnel face by a mechanical cutter tool; subjecting a three-way force detection cutter to squeezing forces; feeding back three-way force data by a three-way force sensor; processing information by a TBM back-end control processor; obtaining a value of rock-cutter contact angle ?; feeding back parameter information to a TBM cutter head control center by a lithology index center; responding by the TBM cutter head control center, obtaining and adjusting parameters by the mechanical cutter tool equipped with the three-way force sensor; and breaking rock by the combined mechanical-hydraulic rock-breaking cutter head.

Abstract: Isolated polynucleotides and polypeptides, and recombinant DNA constructs useful for conferring improved nitrogen use efficiency; compositions (such as plants or seeds) comprising these recombinant DNA constructs; and methods utilizing these recombinant DNA constructs are disclosed. The recombinant DNA constructs comprise a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotides encode abiotic stress tolerance polypeptides.

Abstract: This document provides butyrylcholinesterases having an enhanced ability to hydrolyze acyl ghrelin as well as nucleic acids encoding such butyrylcholinesterases. This document also provides methods and materials for treating obesity and/or aggression. For example, methods for administering a nucleic acid encoding a wild-type or mutant butyrylcholinesterase having the ability to hydrolyze acyl ghrelin to a mammal under conditions wherein the level of acyl ghrelin within the mammal is reduced, under conditions wherein the rate of body weight gain of the mammal is reduced, under conditions wherein the mammal's level of aggression is reduced, and/or under conditions wherein the mammal's rate of developing stress-induced tissue damage are provided.

Abstract: A compound having anti-aging and discoloration resistance effects and a preparation method therefor are provided. The structure of the compound is represented by formula (I). The compound provides longer-lasting anti-aging performance, and has discoloration resistance. The compound may be used as an anti-aging agent in rubber products, especially rubber tires, and can prevent the aging and deterioration of rubber products or rubber tires due to light, heat, oxygen, and fatigue, during use.

Abstract: A back film and a display device are provided. The back film comprises: a central area, having a first edge and a second edge adjacent to the first edge, wherein the first edge extends in a first direction, the second edge extends in a second direction, and the first direction intersects with the second direction; a first foldable area, connected to the first edge of the central area and extending in the first direction; a second foldable area, connected to the second edge of the central area and extending in the second direction; and a third foldable area, connected to a junction between the first edge and the second edge of the central area, and connected further to the first foldable area and the second foldable area.

Abstract: An image processing method includes: obtaining a first target face image in a reference expression state; obtaining user face key point offset information that includes offsets between face key points of a user in a target expression state and face key points of the user in the reference expression state; adjusting face key points of the first target face image in the reference expression state according to the user face key point offset information; and attaching, in a to-be-processed image including a second target face image, an expression texture image of the adjusted first target face image to the second target face image, the second target face image and the first target face image belonging to a same target.

Abstract: Disclosed is a method for achieving space-based autonomous navigation of global navigation satellite system (GNSS) satellites, and relates to the field of satellite navigation technologies. The method includes the following steps: optimizing a DRO, and establishing a dynamic model of an earth-moon space satellite orbit; establishing measurement links, by a low earth orbit (LEO) data relay satellite, with an earth-moon space DRO satellite and a GNSS respectively, and measuring an inter-satellite distance for modeling and linearization; adopting an extended Kalman filter (EKF) method to process inter-satellite measurement data, and autonomously determining a position and velocity of the global navigation satellite system without depending on the ground measurement and control support.

Abstract: The present disclosure provides a data mutex filter circuit and a data mutex filtering method. The data mutex filter circuit has a main input terminal and a main output terminal and including a preprocessing sub-circuit and a 1st-stage filter sub-circuit to an Nth-stage filter sub-circuit which are cascaded, N being an integer greater than or equal to 2. The 1st-stage filter sub-circuit has an input terminal coupled to the preprocessing sub-circuit, and the Nth-stage filter sub-circuit has an output terminal coupled to the main output terminal. Each stage of filter sub-circuit is configured to compare whether input data currently received at the main input terminal is the same as history data stored therein, and feed back a comparison result to the preprocessing sub-circuit; the preprocessing sub-circuit outputs corresponding data to the 1st-stage filter sub-circuit according to the comparison result fed back by each stage of filter sub-circuit.

Abstract: The present disclosure discloses a rock high-stress high-temperature micro-nano indentation test system, comprising: an X, Y, Z three-direction macroscopic adjustment module, an indentation precision loading module, an indentation test module and an indentation data processing module. The rock high-stress high-temperature micro-nano indentation test system further comprise a two-dimensional horizontal stress loading device, a temperature control device and a vacuum device 13. The rock high-stress high-temperature micro-nano indentation test system provided by the present disclosure has distinctive features of modularity and structuralization, and its test results have high accuracy. The rock high-stress high-temperature micro-nano indentation test system is easy to operate, and provides a theoretical and technical system support for testing the mechanical characteristics of the rock under the high-stress and high-temperature environment in the deep region.

Abstract: Provided are a display driving chip, a display apparatus and a display driving method. The display driving chip includes a gaze tracker, an image receiver, an image parser and an image driver, wherein the gaze tracker is configured to achieve real-time locating for the pupil center of human eyes and real-time calculation for gaze point coordinates, and output the gaze point coordinates of human eyes to the image parser; the image receiver is configured to receive image data to be played through a first image interface and input the image data to be played to the image parser; the image parser is configured to compress or decompress the image data to be played according to the gaze coordinates of human eyes and output the image data to the image driver.

Abstract: Provided herein are bifunctional compounds with a moiety (e.g., lenalidomide, thalidomide) that is a binder of an E3 ubiquitin ligase (e.g., Cereblon) and another moiety that is a binder of a target protein (e.g., kinase (e.g., CDK (e.g., CDK9 and/or CDK12))) to induce degradation of the target protein CDK9 and/or CDK12. Also provided are pharmaceutical compositions comprising the bifunctional compounds, and methods of treating and/or preventing diseases (e.g., proliferative diseases, such as cancers (e.g., ovarian cancer, breast cancer, or prostate cancer))). Provided also are methods of inducing the degradation of the target protein (e.g., kinase (e.g., CDK (e.g., CDK9 and/or CDK12))), and methods of inducing apoptosis in a cell in a biological sample or subject by administering the bifunctional compound or composition described herein.

Abstract: A method includes detecting whether there is a very short pitch lag in a speech or audio signal that is shorter than a conventional minimum pitch limitation using a combination of time domain and frequency domain pitch detection techniques. The pitch detection techniques include using pitch correlations in a time domain and detecting a lack of low frequency energy in the speech or audio signal in a frequency domain. The detected very short pitch lag is coded using a pitch range from a predetermined minimum very short pitch limitation that is smaller than the conventional minimum pitch limitation.

Abstract: The present disclosure discloses a horizontal type combined filter separator, including a barrel-shaped structure. The inside of the shell is sequentially divided into a first cavity, a second cavity and a third cavity from a first end and a second end. A fourth cavity is formed in the first cavity. The horizontal type combined filter separator further includes a communicating pipe with one opened end and one closed end; the closed end of the communicating pipe extends into the first cavity, and the opened end passes through the second cavity and extends into the third cavity. The shell is provided with a gas intake connection pipe communicating with the fourth cavity. A plurality of cyclone separators are provided; a gas inlet of each cyclone separator communicates with the fourth cavity; a dust discharging port communicates with the first cavity; and an exhaust port extends into the communicating pipe.