Patents by Inventor Yang Hai

Yang Hai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220315967
    Abstract: Single-module nonribosomal peptide synthetases (NRPSs) and NRPS-like enzymes activate and transform carboxylic acids in both primary and secondary metabolism; and are of great interest due to their biocatalytic potentials. The single-module NRPS IvoA is essential for fungal pigment biosynthesis. As disclosed herein, we show that IvoA catalyzes ATP-dependent unidirectional stereoinversion of L-tryptophan to D-tryptophan with complete conversion. While the stereoinversion is catalyzed by the epimerization (E) domain, the terminal condensation (C) domain stereoselectively hydrolyzes D-tryptophanyl-S-phosphopantetheine thioester and thus represents a noncanonical C domain function. Using IvoA, we demonstrate a biocatalytic stereoinversion/deracemization route to access a variety of substituted D-tryptophan analogs in high enantiomeric excess.
    Type: Application
    Filed: September 18, 2020
    Publication date: October 6, 2022
    Applicant: The Regents of the University of California
    Inventors: Yi Tang, Yang Hai
  • Publication number: 20040179933
    Abstract: A new and improved lift mechanism which is suitably adapted for raising and lowering a pedestal/heater assembly inside a processing chamber for semiconductor wafer substrates. The pedestal/heater assembly lift mechanism includes a drive motor which is directly coupled through a shaft coupling to a threaded lead screw for rotating the lead screw in the clockwise or counterclockwise direction. The lead screw threadibly engages the pedestal/heater assembly for selectively raising and lowering the pedestal/heater assembly inside the processing chamber.
    Type: Application
    Filed: March 11, 2003
    Publication date: September 16, 2004
    Applicant: Taiwan Semiconductor Manufacturing Co., Ltd.
    Inventors: Kuo-Hsi Huang, Chang-Yi Hsieh, Yang-Hai Fan, Shih-Chang Hsu, Hao-Quan Yu, Zheng-Zong Twu