Abstract: The present invention relates to a vaccine composition for preventing SARS-CoV-2, comprising mRNA encoding an S mutant antigen of SARS-CoV-2 virus, wherein a vaccine for preventing SARS-CoV-2 according to the present invention exhibits excellent stability and high immunogenicity in vivo, and the vaccine is thus easy to store and use, and excellent preventive effect thereof against COVID-19 can be expected.

Abstract: The present disclosure relates to a mRNA delivery composition comprising cationic lipid-based liposome. The mRNA delivery composition according to the present disclosure is superb in terms of storage stability and exhibits high intracellular delivery and expression rates in vivo and thus, can enhance the stability and efficiency of mRNA vaccines for cancer therapy or mRNA vaccines for prevention of viral infections.

Abstract: A blood pump for causing blood to flow in one direction is used for a blood oxidation system that circulates blood in a body to an oxidizer so as to supply oxygen into the body from outside the body. The blood pump includes an outer wall having a gas outlet port formed through a lateral surface thereof; a blood chamber having a pouch which is inserted into the outer wall and of which opposite ends are connected to opposite ends of the outer wall, respectively; a pump injection valve fluid-communicably coupled to one end of the blood chamber and blocking blood from flowing to the blood chamber; and a pump discharge valve fluid-communicably coupled to the other end of the blood chamber and blocking blood from flowing from the blood chamber.

Abstract: The present invention relates to a cannula for femoral arterial bidirectional (a heart direction and a distal lower extremity direction) perfusion. The cannula, which has a cannula tube to be inserted into a blood vessel of the femoral artery, includes a perfusion guide channel formed as a concave part from a predetermined portion of an inner circumferential surface at an end of the cannula tube to the opposite end thereof in a length direction and further includes a through-hole provided at a boundary portion between the perfusion guide channel and the cannula tube in an end direction of the cannula tube, or includes a through-hole provided in a predetermined portion of an inner circumferential surface of an end of the cannula tube and a guide cover provided at an upper portion of the through-hole to cover the upper portion of the through-hole and guide perfusion.

Abstract: The present invention relates to a cannula for femoral arterial bidirectional (a heart direction and a distal lower extremity direction) perfusion. The cannula, which has a cannula tube to be inserted into a blood vessel of the femoral artery, includes a perfusion guide channel formed as a concave part from a predetermined portion of an inner circumferential surface at an end of the cannula tube to the opposite end thereof in a length direction and further includes a through-hole provided at a boundary portion between the perfusion guide channel and the cannula tube in an end direction of the cannula tube, or includes a through-hole provided in a predetermined portion of to an inner circumferential surface of an end of the cannula tube and a guide cover provided at an upper portion of the through-hole to cover the upper portion of the through-hole and guide perfusion.

Abstract: The present invention relates to an integrated double cannula for ECMO. The integrated double cannula is configured to be inserted into a blood vessel through skin for ECMO. The integrated double cannula includes a cannula body in which a blood introduction part and a blood supply part are integrally formed inside a single pipe with a partition wall being therebetween, wherein an end of the cannula body is opened through an end hole, another end of the cannula body is opened through an outlet and an inlet arranged side by side and connected respectively to the blood introduction part and the blood supply part, and one or more side holes and one or more discharge holes connected respectively to the blood introduction part and the blood supply part are formed in a lateral portion of the cannula body.