Patents by Inventor Yang-I Lin

Yang-I Lin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 7-(substituted)cycloalkylamino-1 -(substituted)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids
    Patent number: 4992449
    Abstract: Novel antibacterial compounds of the formula: ##STR1## in which R.sub.1 is alkyl (C.sub.1 -C.sub.4), cycloalkyl (C.sub.3 -C.sub.6), alkoxy (C.sub.1 -C.sub.4), alkylamino (C.sub.1 -C.sub.3), vinyl, phenyl, benzyl, --CH.sub.2 CH.sub.2 F or mono or polysubstituted phenyl (wherein the substituent is halogen, CF.sub.3 or OCH.sub.2 F); n is an integer of from 1 to 4; and R.sub.2 is cis or trans hydroxy, amino, mono or disubstituted alkyl (C.sub.1 -C.sub.3) amino and the pharmacologically accepted salts thereof are described.
    Type: Grant
    Filed: February 1, 1990
    Date of Patent: February 12, 1991
    Assignee: American Cyanamid Company
    Inventors: Panayota Bitha, Yang-I Lin
  • 8-fluoro and 7, 8, 10-trifluoro-9-(substituted)-6-oxo-6H-benzo-(C)quinolizine-5-carboxylic acids
    Patent number: 4948894
    Abstract: Novel substituted quinolinecarboxylic acid derivatives of the formula: ##STR1## wherein R.sup.1 is hydrogen, alkali metal, alkaline earth metal or lower alkyl; R.sub.2 is hydrogen, benzyl or alkyl (C.sub.1 -C.sub.3); X is hydrogen or fluoro; which have antibacterial activity, intermediates useful in the preparation of the compounds, methods of producing and using the compounds to treat bacterial infections in animals.
    Type: Grant
    Filed: December 6, 1989
    Date of Patent: August 14, 1990
    Assignee: American Cyanamid Company
    Inventors: Daniel B. Moran, Yang-I Lin, Carl B. Ziegler
  • 7-(substituted)piperaziny l-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids
    Patent number: 4940710
    Abstract: 7-(substituted)piperazinyl-1-ethyl-6-fluoro-4-oxo-3-quinolinecarboxylic acids, the pharmacologically acceptable salts thereof, compositions containing them, processes and intermediates for producing them, and methods of using them to treat bacterial infections in warm-blooded animals.
    Type: Grant
    Filed: August 5, 1987
    Date of Patent: July 10, 1990
    Assignee: American Cyanamid Company
    Inventors: Phaik-Eng Sum, Joseph P. Joseph, Carl B. Ziegler, Jr., Daniel B. Moran, Yang-I Lin
  • Synthesis of cisplatin analogs
    Patent number: 4937358
    Abstract: This disclosure sets forth a novel process for producing cisplatin analogs which possess antitumor activity.
    Type: Grant
    Filed: December 8, 1988
    Date of Patent: June 26, 1990
    Assignee: American Cyanamid Company
    Inventors: Panayota Bitha, Joseph J. Hlavka, Yang-I Lin
  • 8-fluoro and 7,8,10-trifluoro-9-(substituted)-6-oxo-6H-benzo(C)quinolizine-5-carboxyl ic acids
    Patent number: 4923868
    Abstract: Novel substituted quinolinecarboxylic acid derivatives of the formula: ##STR1## wherein R.sup.1 is hydrogen, alkali metal, alkaline earth metal or lower alkyl; R.sub.2 is hydrogen, benzyl or alkyl(C.sub.1 -C.sub.3); X is hydrogen or fluoro; which have antibacterial activity, intermediates useful in the preparation of the compounds, methods of producing and using the compounds to treat bacterial infections in animals.
    Type: Grant
    Filed: February 21, 1989
    Date of Patent: May 8, 1990
    Assignee: American Cyanamid Company
    Inventors: Daniel B. Moran, Yang-I Lin, Carl B. Ziegler
  • (2,2-bis(aminomethyl)-1,3-propranediol-N,N')platinum complexes
    Patent number: 4900756
    Abstract: Organic-platinum complexes useful as anti-cancer agents in the treatment of tumors sensitive to the subject compounds are described.
    Type: Grant
    Filed: July 15, 1988
    Date of Patent: February 13, 1990
    Assignee: American Cyanamid Company
    Inventors: Ralph G. Child, Panayota Bitha, Joseph J. Hlavka, Yang-I Lin
  • (Gem-heterocyclodimethanamine-N,N')platinum complexes
    Patent number: 4880790
    Abstract: Organic platinum complexes active as anti-tumor agents in warm-blooded animals, and methods for synthesis of same, are described.
    Type: Grant
    Filed: January 31, 1986
    Date of Patent: November 14, 1989
    Assignee: American Cyanamid Company
    Inventors: Ralph G. Child, Panayota Bitha, Joseph J. Hlavka, Yang-I Lin
  • Water soluble platinum complexes of novel malonate derivatives
    Patent number: 4870070
    Abstract: This disclosure describes water soluble platinum complexes of novel malonate derivatives which possess the property of inhibiting the growth of tumors in mammals.
    Type: Grant
    Filed: August 10, 1987
    Date of Patent: September 26, 1989
    Assignee: American Cyanamid Company
    Inventors: Panayota Bitha, Joseph J. Hlavka, Yang-I Lin
  • Platinum complexes of amines with novel dibasic acids
    Patent number: 4866092
    Abstract: Novel organic compounds of the formula ##STR1## where R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and alkyl(C.sub.1 -C.sub.6); or R.sub.1 and R.sub.2 taken together are selected from the group consisting of ##STR2## where n is an integer 3-6, ##STR3## where m is an integer 3-6, and ##STR4## and L is selected from the group consisting of --O--, --CH.sub.2 --, ##STR5## and >NR.sub.3 where R.sub.3 is alkyl(C.sub.1 -C.sub.6) or --CH.sub.2 CH.sub.2 OH, which have antineoplastic activity, compositions containing the compounds and methods of using the compounds to treat tumors in mammals.
    Type: Grant
    Filed: March 27, 1987
    Date of Patent: September 12, 1989
    Assignee: American Cyanamid Company
    Inventors: Panayota Bitha, Ralph G. Child, Joseph J. Hlavka, Yang-I Lin
  • Process for preparing 2-chloro-4,5-difluorobenzoic acid
    Patent number: 4833270
    Abstract: This disclosure describes a novel process for preparing 2-chloro-4,5-difluorobenzoic acid which is useful in the preparation of 7-(substituted)piperazinyl-1-substituted-6-fluoro-1,4-dihydro-4-oxo-3-quin oli necarboxylic acid antibacterial agents.
    Type: Grant
    Filed: December 21, 1987
    Date of Patent: May 23, 1989
    Assignee: American Cyanamid Company
    Inventors: Panayota Bitha, Yang-I Lin
  • Synthesis of cisplatin analogs
    Patent number: 4808730
    Abstract: This disclosure sets forth a novel process for producing cisplatin analogs which possess antitumor activity.
    Type: Grant
    Filed: June 23, 1987
    Date of Patent: February 28, 1989
    Assignee: American Cyanamid Company
    Inventors: Panayota Bitha, Joseph J. Hlavka, Yang-I Lin
  • (2,2,-bis(aminomethyl)-1,3-propanediol-N,N')platinum complexes
    Patent number: 4760157
    Abstract: Novel organic-platinum compounds selected from those of the formulae: ##STR1## wherein L and L' are selected from the group consisting of halide, nitrate, sulfate and a monobasic carboxylate such as acetate or hydroxy acetate or L and L' taken together are a dibasic carboxylate selected from the group consisting of ##STR2## oxalic acid, methylmalonic acid, succinic acid and tartronic acid, or L and L' taken together are a tribasic carboxylate selected from the group consisting of ##STR3## taken together is ascorbic acid and X is selected from the group consisting of halogen and hydroxy.
    Type: Grant
    Filed: January 31, 1986
    Date of Patent: July 26, 1988
    Assignee: American Cyanamid Company
    Inventors: Ralph G. Child, Panayota Bitha, Joseph J. Hlavka, Yang-I Lin
  • Heterocyclic-1,2-diamine platinum complexes
    Patent number: 4716157
    Abstract: This disclosure describes platinum complexes of heterocyclic-1,2-diamines which possess the property of inhibiting the growth of tumors in mammals.
    Type: Grant
    Filed: March 20, 1986
    Date of Patent: December 29, 1987
    Assignee: American Cyanamid Company
    Inventors: Panayota Bitha, Ralph G. Child, Joseph J. Hlavka, Yang-I Lin
  • Platinum complexes of diamino-dideoxy sugars and di- or tricarboxylic acids
    Patent number: 4703115
    Abstract: Platinum complexes and Di- or Tricarboxylic acids which is then reacted with the appropriate di- or tricarboxylic acid in aqueous medium.
    Type: Grant
    Filed: December 17, 1984
    Date of Patent: October 27, 1987
    Assignee: American Cyanamid Company
    Inventors: Joseph J. Hlavka, Ralph G. Child, Panayota Bitha, Yang-i Lin
  • 3,6-bis (substituted) acridine N-oxides and N,N-dioxides and methods of restoring, stimulating or enhancing the immune system with them
    Patent number: 4696936
    Abstract: This invention concerns novel 3,6-bis(substituted) acridine N-oxides and N,N-dioxides which are active as modulators of the immune system in warm-blooded animals.
    Type: Grant
    Filed: November 9, 1984
    Date of Patent: September 29, 1987
    Assignee: American Cyanamid Company
    Inventors: Ralph G. Child, Thomas L. Fields, Raymond G. Wilkinson, Yang-I Lin
  • Platinum complexes of amines with dibasic acids
    Patent number: 4675336
    Abstract: Novel organic compounds of the formula ##STR1## Where R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and alkyl(C.sub.1 -C.sub.6); or R.sub.1 and R.sub.2 taken together are selected from the group consisting of ##STR2## where n is an integer 3-6, ##STR3## where m is an integer 3-6, and ##STR4## and L is selected from the group consisting of --O--, --CH.sub.2 --, ##STR5## where R.sub.3 is alkyl(C.sub.1 -C.sub.6) or --CH.sub.2 CH.sub.2 OH, which have antineoplastic activity, compositions containing the compounds and method of using the compounds to treat tumors in mammals.
    Type: Grant
    Filed: June 26, 1985
    Date of Patent: June 23, 1987
    Assignee: American Cyanamid Company
    Inventors: Panayota Bitha, Ralph G. Child, Joseph J. Hlavka, Yang-I Lin
  • Hydroxylated 1,2-diaminocyclohexane platinum complexes
    Patent number: 4670458
    Abstract: This disclosure describes platinum complexes of 3.beta., 4.alpha.-diamino-1.alpha.,2.alpha.-cyclohexanediol which possess the property of inhibiting the growth of tumors in mammals.
    Type: Grant
    Filed: January 31, 1986
    Date of Patent: June 2, 1987
    Assignee: American Cyanamid Company
    Inventors: Joseph J. Hlavka, Yang-I Lin, Panayota Bitha
  • Substituted acridine derivatives useful as modulators of the immune system
    Patent number: 4666917
    Abstract: This invention concerns novel substituted acridine compounds which are useful as modulators of the immune system in warm-blooded animals.
    Type: Grant
    Filed: November 9, 1984
    Date of Patent: May 19, 1987
    Assignee: American Cyanamid Company
    Inventors: Raymond G. Wilkinson, Yang-I Lin
  • Platinum complexes of aliphatic tricarboxylic acids
    Patent number: 4665210
    Abstract: Platinum complexes of aliphatic tricarboxylic acids useful for inducing regression and/or palliation of cancer diseases in mammals.
    Type: Grant
    Filed: October 28, 1985
    Date of Patent: May 12, 1987
    Assignee: American Cyanamid Company
    Inventors: Panayota Bitha, Ralph G. Child, Joseph J. Hlavka, Yang-I Lin
  • Platinum complexes of polyhydroxylated alkylamines and 2-polyhydroxylated alkyl-1,2-diaminoethanes
    Patent number: 4587331
    Abstract: Platinum complexes of polyhydroxylated alkylamines and 2-polyhydroxylated alkyl-1,2-diaminoethanes useful for inducing regression and/or palliation of cancer diseases in mammals.
    Type: Grant
    Filed: December 17, 1984
    Date of Patent: May 6, 1986
    Assignee: American Cyanamid Company
    Inventors: Joseph J. Hlavka, Ralph G. Child, Panayota Bitha, Yang I. Lin