Abstract: The present invention relates to a pharmaceutical composition for preventing or treating alopecia areata acting as a functional antagonist for S1P receptor's subtypes S1PR1 and S1PR4, and more particularly, relates to a pharmaceutical composition containing as an active ingredient a sphingolipid compound acting as a functional antagonist for S1PR1 and S1PR4, does not cause cardiovascular side effects, and is effective in preventing or treating alopecia areata.

Abstract: The present invention relates to a method for preparing metal oxide nanoparticles and metal oxide nanoparticles prepared thereby. The method includes: dipping a cathode and an anode formed of a metal for forming oxide, in an inorganic electrolyte solution containing halogen salt, and applying voltage to the anode and the cathode to form, on the anode, metal oxide forming an anode surface. According to a method of the present invention, disadvantages of typical nanoparticle synthesizing methods may be solved to cheaply and rapidly manufacture nanoparticles having various structures through a single process without using a surfactant. In practicing a method of the invention, metal oxide nanoparticles may be rapidly formed, nanoparticles having excellent crystallinity may be produced, and factors of the anodizing method, such as voltage, temperature, an electrolyte, and an electrolyte concentration may be changed to simply adjust a shape of the nanoparticles.

Abstract: The present invention relates to a method for preparing metal oxide nanoparticles and metal oxide nanoparticles prepared thereby, and more particularly, to an method for preparing metal oxide nanoparticles, the method including: dipping a cathode and an anode formed of a metal for forming oxide, in an inorganic electrolyte solution containing halogen salt (step 1); and applying voltage to the anode and the cathode to form, on the anode, metal oxide forming an anode surface (step 2). According to a method for preparing metal oxide nanoparticles of the present invention, disadvantages of typical nanoparticle synthesizing methods may be solved to cheaply and rapidly manufacture nanoparticles having various structures through a simple and single process without using a surfactant. Since an anodizing method requires only a power supply device having a low voltage of 30 V or less and an electrolyte, and is performed at room temperature, the anodizing method does not require an additional device or installation.