Abstract: This invention relates to treating inflammatory and immune diseases with certain pyrimidinone compounds that bind to CXCR3 receptors. The pyrimidinone compounds are covered by the formula (I) shown below. Each variable is defined in the specification.

Abstract: A method of control and management of production line. More than one performance indices are used to remind production management department to adjust process throughput and labor resources to avoid the occurrence of bottleneck machine. A performance index of equipment Ieq and a performance index of work in process Iwip are calculated to several parameters. When Ieq is larger than 1.0, the number of available machines is enough to reach the target. When Ieq is smaller than 1.0, it indicated the available machines are not enough, so that whether accelerating on-line speed is required or not has to be decided. Regarding Iwip, when Iwip is larger than 1.0, the target can be reached. On the contrary, if Iwip is smaller than 1.0, the target cannot be reached. The throughput has to be enhanced to reach the target.

Abstract: A method of control and management of production line. More than one performance indices are used to remind production management department to adjust process throughput and labor resources to avoid the occurrence of bottleneck machine. A performance index of equipment Ieq and a performance index of work in process Iwip are calculated to several parameters. When Ieq is larger than 1.0, the number of available machines is enough to reach the target. When Ieq is smaller than 1.0, it indicated the available machines are not enough, so that whether accelerating on-line speed is required or not has to be decided. Regarding Iwip, when Iwip is larger than 1.0, the target can be reached. On the contrary, if Iwip is smaller than 1.0, the target cannot be reached. The throughput has to be enhanced to reach the target.