Abstract: Techniques for memory access management in a distributed computing system are described herein. In some aspects, the techniques described herein relate to a method for memory access management in a distributed computing system, where the method includes: receiving a first request to execute a first operation using a distributed architecture and in a uniform memory access (UMA) mode, wherein the distributed architecture comprises a first processor, a first memory that is local to the first processor, and a second memory that is remote to the first processor; subsequent to receiving the first request and a first delay period, transmitting first data associated with the first operation to the first processor, wherein the first data is stored in the first memory; and subsequent to receiving the first request, transmitting second data associated with the first operation to the first processor, wherein the second data is stored in the second memory.

Abstract: Cas12 protein, guide polynucleotide, inactivated Cas12 mutant, fusion protein or conjugate including the Cas12 protein, isolated nucleic acid, CRISPR-Cas12 system, vector system, delivery system, cell, pharmaceutical composition, and kit, and the use thereof are provided.

Abstract: The disclosure provides a mouldable artificial bone composite material and a preparation method thereof. The mouldable artificial bone composite material is characterized in a composition composed of a degradable polymer material and inorganic particles distributed in the polymer material. The average molecular weight of the polymer material is 1,000 Da to 20,000 Da. The inorganic particles are composed of calcium-phosphorus compounds. The artificial bone composite material has a shape of a mouldable plasticine. The disclosure provides an artificial bone composite material that can be freely shaped and injected, and the disclosure further provides a preparation method of the artificial bone composite material.

Abstract: The disclosure provides a mouldable artificial bone composite material and a preparation method thereof. The mouldable artificial bone composite material is characterized in a composition composed of a degradable polymer material and inorganic particles distributed in the polymer material. The average molecular weight of the polymer material is 1,000 Da to 20,000 Da. The inorganic particles are composed of calcium-phosphorus compounds. The artificial bone composite material has a shape of a mouldable plasticine. The disclosure provides an artificial bone composite material that can be freely shaped and injected, and the disclosure further provides a preparation method of the artificial bone composite material.

Abstract: Cas12 protein, guide polynucleotide, inactivated Cas12 mutant, fusion protein or conjugate including the Cas12 protein, isolated nucleic acid, CRISPR-Cas12 system, vector system, delivery system, cell, pharmaceutical composition, and kit, and the use thereof are provided.

Abstract: Method for assisting in a travel arrangement includes receiving, by a mobile terminal, a travel instruction, the travel instruction including a destination; obtaining vehicle information of a vehicle corresponding to the mobile terminal; obtaining destination information of the destination; and assisting in the travel arrangement based on at least one of the vehicle information or the destination information.

Abstract: A method for operating a wafer carrier handling system is provided. The method includes causing a robot arm of a transfer robot to approach a rack apparatus along an approaching path, wherein the robot arm grips a wafer carrier; automatedly opening a door of the rack apparatus when the robot arm of the transfer robot is in front of the rack apparatus; when the door of the rack apparatus is open, using the robot arm, placing the wafer carrier onto the rack apparatus; causing the robot arm to leave the rack apparatus; and after causing the robot arm to leave the rack apparatus, automatedly closing the door of the rack apparatus.

Abstract: A method for operating a semiconductor processing system is provided. The method includes performing a semiconductor process by a semiconductor fabrication apparatus, wherein the semiconductor fabrication apparatus comprises a plurality of load ports arranged substantially along a first direction in a top view; moving a stage between a first region and a second region substantially along a second direction intersecting the first direction in the top view, wherein the stage supports a transfer robot, and the first region is nearer to the load ports than the second region is; using the transfer robot, transferring a wafer carrier between a stocker apparatus and a semiconductor fabrication apparatus when the stage is at the first region; and performing a maintenance process to the semiconductor fabrication apparatus when the stage is at the second region.

Abstract: A submicron-scale microfluidic experimental apparatus under high-temperature and high-pressure conditions and a method of using the apparatus are provided.

Abstract: An objective of the present invention is to provide antigen-binding molecules that specifically bind to HER2 mutant. The present invention provides antigen-binding molecules that specifically bind to HER2 mutant, and are capable of modulating and/or activating an immune response; compositions comprising the antigen-binding molecule; and methods of using the same.

Abstract: Ultrasound image devices, systems, and methods are provided. An ultrasound imaging system, comprising an intraluminal imaging device including an ultrasound transducer array configured to obtain first signal data and second signal data representative of a body lumen, the first signal data and the second signal data associating with different imaging modes of the ultrasound transducer array; and a processor in communication with the intraluminal imaging device and configured to generate motion data of a flow within the body lumen based on the first signal data; generate structural data of the body lumen based on the second signal data; combine the motion data and the structural data based on a first threshold; and output, to a display in communication with the processor, an intraluminal ultrasound image representing the combined motion data and structural data.

Abstract: The present disclosure relates to Cas12 proteins and uses thereof. In certain embodiments, a Cas12 protein is provided whose amino acid sequence has at least 50% sequence identity to SEQ ID NO: 1 and includes one, two, or more amino acid differences relative to SEQ ID NO: 1. In certain embodiments, the Cas12 protein has at least 50% sequence identity to SEQ ID NO: 18. In certain embodiments, the Cas12 protein recognizes a PAM sequence of A. In certain embodiments, gene-editing efficiency of a wild-type Cas12 protein in mammalian cells is improved by introducing rational and irrational amino acid mutations. In certain embodiments, the Cas12 protein exhibits increased editing efficiency and/or a reduced off-target rate and, by virtue of recognizing a single-base A PAM, enables editing of target sequences that were previously difficult to edit, thereby substantially expanding the range of editable targets.

Abstract: Provided are a mutated V-type CRISPR enzyme and use thereof. By means of the protein mutation rational mutagenesis technology, the restriction on the recognition and cleavage of DNA substrates by RuvC in Cas12a or Cas12b is removed, so that RNA substrates can be efficiently recognized and cleaved, and the problem of insufficient RNA substrate recognition efficiency in practical applications is solved. The reaction efficiency of Cas12 with the RNA substrates after the activation of trans-cleavage activity is improved, and the reporting efficiency of Cas12 using an RNA probe is improved.

Abstract: The systems, methods, and devices disclosed herein relate to a multi-layer structures arranged in a vertically orientation. In some embodiments, a computing assembly can include a first cooling system, a first electronics layer, a second cooling system, and a second electronics layer. The first cooling system can be disposed on top of and can be in thermal communication with the first electronics layer. The first electronics layer array includes an array of integrated circuit dies that are in electronic communication with each other in a plane that is orthogonal to power delivery. The first electronics layer can be disposed on top of and can be in thermal communication with the second cooling system, and the second cooling system can be disposed on top of and can be in thermal communication with the second electronics layer. The second electronics layer includes an array of power delivery modules. In some embodiments, at least one layer can use system on wafer packaging.

Abstract: The invention relates to a double-traction transfer vehicle used for trailers, comprising a front traction mechanism, two traction bars arranged in a cross, and a transfer frame connected with the trailer and provided with a running device, one end of each traction bar near the front traction mechanism is connected to the front traction mechanism by the retractor, and one end of each traction bar near the transfer frame is hinged to the transfer frame, the top of the transfer frame is provided with a saddle for connection to the trailer. The invention can meet the transportation requirements of one tractor pulling multiple trailers, greatly reduce the cost of equipment for vehicle purchase and labor costs, alleviate the road blockage pressure caused by the operation of multiple tractors wherein each tractor only pull one trailer at the same time, and improve the efficiency of the vehicle for transporting goods.

Abstract: The present disclosure relates to an isolated Cas13 protein and use thereof. The amino acid sequence of the isolated Cas13 protein comprises a sequence having ?50% sequence identity with the sequence as shown in any one of SEQ ID NO: 1-SEQ ID NO: 7, and SEQ ID NO: 60. The Cas13 protein is a Cas13 enzyme with an endonuclease activity, which can be used in a CRISPR/Cas system to achieve targeting and modification of a target nucleic acid, enriching the enzymes and systems available in a CRISPR-C as editing system.

Abstract: A method and a device for data migration of a blockchain. The method includes generating a state tree based on state data of accounts in the blockchain, in which the state tree is a B+ tree based on a copy-on-write technology, and each leaf node of the state tree is configured to store the state data; determining a target state tree to be migrated from the generated state tree when data migration is triggered; sending state data of the target state tree to an extended node of a master node; if migration completion information is received from the extended node, updating a data mapping table stored in the master node, in which the data mapping table is configured to represent a mapping relationship between state data stored in the extended node and the extended node; and deleting the target state tree in the master node.